anti-Desmoglein 3 (DSG3) 抗体

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. 再加上,我们可以发Desmoglein 3 试剂盒 (21)Desmoglein 3 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DSG3 1830 P32926
DSG3 13512  
DSG3 291752  
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antibodies-online.cn销售最多的anti-Desmoglein 3 抗体

Showing 10 out of 232 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB 100 μL Log in to see 2至3个工作日
小鼠 非结合性 ICC, IF, IHC, IHC (p), IP, WB Western Blot: Desmoglein-3 Antibody (5H10) [NBP1-78984] - Analysis of Desmoglein 3 expression in HaCat cell lysate using NBP1-78984. Immunohistochemistry: Desmoglein-3 Antibody (5H10) [NBP1-78984] - Analysis of Desmoglein 3 on human skin cancer using NBP1-78984. 0.1 mL Log in to see 7至9个工作日
小鼠 非结合性 ICC, FACS, IF, IHC (p), IP, IHC, WB 0.1 mL Log in to see 7至9个工作日
非结合性 WB Western blot analysis of Desmoglein 3 expression in A431 (A), HeLa (B), Raw264.7 (C), PC12 (D) whole cell lysates. 200 μL Log in to see 13至14个工作日
小鼠 非结合性 ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using DSG3 mAb against human DSG3 (AA: 55-159) recombinant protein. (Expected MW is 37.5 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8至11个工作日
非结合性 EIA, WB Western blot analysis of Desmoglein-3 Antibody (N-term) in WiDr cell line lysates (35ug/lane). This demonstrates the DSG3 antibody detected the DSG3 protein (arrow). 0.4 mL Log in to see 6至8个工作日
小鼠 非结合性 CyTOF, ELISA, FACS, IHC, WB ELISA: Desmoglein-3 Antibody (6G2C11) [NBP2-37259] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng); Immunohistochemistry: Desmoglein-3 Antibody (6G2C11) [NBP2-37259] - Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using DSG3 mouse mAb with DAB staining. 0.1 mL Log in to see 7至9个工作日
非结合性 IHC (p) Immunohistochemistry-Paraffin: Desmoglein-3 Antibody  - Staining of human esophagus shows moderate membranous positivity in squamous epithelial cells. Immunohistochemistry-Paraffin: Desmoglein-3 Antibody  - Staining of human esophagus shows high expression. 100 μL Log in to see 10至13个工作日
小鼠 非结合性 IHC (fro), WB   5 mL Log in to see 6至8个工作日
非结合性 ELISA, WB Western blot analysis of DSG3 using LOVO whole cell lysates 100 μL Log in to see 11至12个工作日

引用最多的anti-Desmoglein 3 抗体

  1. Human Monoclonal Desmoglein 3 Primary Antibody for ICC, IF - ABIN4305016 : Proby, Ota, Suzuki, Koyasu, Gamou, Shimizu, Wahl, Wheelock, Nishikawa, Amagai: Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgaris. in The British journal of dermatology 2000 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal Desmoglein 3 Primary Antibody for ICC, FACS - ABIN151179 : Wu, Stanley, Cotsarelis: Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. in The Journal of investigative dermatology 2003 (PubMed)
    Show all 6 Pubmed References

  3. Human Monoclonal Desmoglein 3 Primary Antibody for IHC (fro), IP - ABIN2473333 : Smith, Richards, Yasin, Sangster, Sridaran: Changes in rat luteal ultrastructure and P450scc mRNA and protein content after in vivo treatment with a gonadotropin-releasing hormone agonist. in Biology of reproduction 1991 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal Desmoglein 3 Primary Antibody for FACS, IF - ABIN5576864 : Mahoney, Hu, Brennan, Bazzi, Christiano, Wahl: Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. in Experimental dermatology 2006 (PubMed)

更多抗Desmoglein 3的相互作用对抗体

Human Desmoglein 3 (DSG3) interaction partners

  1. flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes

  2. our findings suggest that Dsg3 functions as a key in cell-cell adhesion through at least a mechanism of regulating E-cadherin membrane trafficking

  3. Desmoglein 3 Order and Dynamics in Desmosomes

  4. Data indicate that all 3 monoclonal antibodies (mAbs) targeted the same extracellular cadherin (EC) domain on desmoglein 3 (Dsg3), caused Dsg3 internalization in primary keratinocytes, and caused suprabasal blisters in skin.

  5. DSG3 was a key prognostic factor and predictor for neoadjuvant concurrent chemoradiotherapy response in rectal cancer patients.

  6. Treg cells exert a clear down-regulatory effect on the Dsg3-driven T-cell response and, accordingly, the formation of Dsg3-specific IgG antibodies

  7. Data identify DSG3 as a negative prognostic biomarker in resected pancreatic ductal adenocarcinoma, as high DSG3 expression is associated with poor overall survival and poor tumour-specific survival.

  8. this study directly demonstrates the occurrence of desmoglein 3 molecules outside of desmosomes and reveales that the adhesive properties of these molecules do differ depending on their localization.

  9. DSG2 and DSG3 might be potential diagnostic markers for squamous cell carcinoma of the lung and DSG3 could be a potential differentiation marker for lung cancer.

  10. alterations of their expression suggest a role of Dsg3 and gamma-catenin (additionally to E-cadherin/beta-catenin) as biomarkers of malignant transformation risk of oral dysplasia and the biological behavior (aggressiveness) of oral cancer, respectively

  11. In endometrial luminal epithelium, cadherin 6, desmoglein 2 and plexin b2 were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.

  12. the Dsg3 epitopes targeted by pathogenic mPV IgG are human specific in mice

  13. Pemphigus vulgaris is characterized by low IgG reactivities to specific self-antigens along with high IgG reactivity to desmoglein 3.

  14. High DSG3 mRNA expression is associated with esophageal squamous cell carcinoma.

  15. Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3.

  16. Dsg3 did not associate with rafts in cells lacking desmosomal proteins.

  17. this study identifies a novel Dsg3-mediated c-Jun/AP-1 regulatory mechanism and PKC-dependent Ezrin phosphorylation that could be responsible for Dsg3-associated cancer metastasis.

  18. The data showed that serum autoantibodies of patients, previously identified as Dsg1 and Dsg3 positive, are able to recognize continuous linear epitope regions of both Dsg1 and Dsg3 proteins using pin-bound overlapping peptides in modified ELISAs.

  19. DSG3 functions as an oncogene and facilitates cancer growth and invasion in head and neck cancer cells

  20. The conformational Dsg3 ELISA index reflected the pathogenicity of anti-Dsg3 antibodies more accurately than the conventional Dsg3 ELISA index in pemphigus vulgaris.

Mouse (Murine) Desmoglein 3 (DSG3) interaction partners

  1. flotillin has a role in desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes

  2. Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients.

  3. Dsg3, via p38 MAPK, regulates the spatial distribution of the keratin filament network and stabilizes cell adhesion.

  4. Squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in paraneoplastic pemphigus (PNP).

  5. Dsg3 deficiency results in perturbation of the desmosomal network at the transcriptional, translational, and interaction level, kinase activation, proteinase-mediated degradation, and hyper-adhesion. (Review)

  6. Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models

  7. IgG and IgM antibodies against desmoglein 3 have a pathogenic role in blister formation in pemphigus vulgaris

  8. the adult passive transfer mouse model is ideally suited for detailed studies of Dsg3 antibody-mediated signaling in adult skin.

  9. These data indicate a contribution of Dsg depletion to pemphigus vulgaris pathogenesis dependent on Ca(2+)-induced differentiation.

  10. Transgenic expression of Dsg1 rescued the severe B6-Dsg3(-/-) phenotype and provided a syngeneic mouse model of pemphigus vulgaris.

  11. Aire has an important role in Dsg3 expression as well as in selection of T cells that help B cells to produce anti-Dsg3 IgG in thymus.

  12. Loss of tolerance against Dsg3 in both B and T cells is important for the development of autoimmune state of pemphigus vulgaris.

  13. Patchy hair loss in pemphigus vulgaris model mice as in Dsg3(-/-) mice. Ultrastructure of telogen hair follicles same as PV model mice and Dsg3(-/-) mice. Anti-Dsg3 autoantibodies interfere with cell-cell adhesion of keratinocytes in PV model mice.

  14. perturbation of desmoglein 3 found in the Dsg3bal-Pas mice resulted in disadhesion of keratinocytes manifested with blistering phenotype.

  15. anti-Dsg3 IgG antibodies can directly access Dsg3 present in desmosomes in vivo and cause the subsequent desmosome separation that leads to blister formation in pemphigus vulgaris

  16. In pemphigus vulgaris antibodies were dominantly raised against middle to C-terminal extracellular domains of mouse Dsg3 where amino acid sequences are less conserved among desmoglein isoforms. Those antibodies may also be involved in blister formation.

  17. importance of the companion layer, and particularly the Dsg1 and Dsg3 in this layer, in anchoring the anagen hair to the follicle.

  18. Northern Blot analysis of wild-type and Plucked (pk) mutant mice indicates that expression of both desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) is up-regulated in the skin of mutant pk mice

  19. skin-specific Dsg3 serves as an autoantigen in chronic skin inflammatory diseases accompanied by mast cell degranulation, including both murine systemic lupus erythematosus and other autoinflammatory diseases

  20. Reduction of Dsg3 might be relevant to blister formation in pemphigus vulgaris.

Desmoglein 3 (DSG3) 抗原简介


Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Gene names and symbols associated with anti-Desmoglein 3 (DSG3) 抗体

  • desmoglein 3 (DSG3) 抗体
  • desmoglein 3 (Dsg3) 抗体
  • bal 抗体
  • balding 抗体
  • CDHF6 抗体
  • DSG3 抗体
  • PVA 抗体

Protein level used designations for anti-Desmoglein 3 (DSG3) 抗体

desmoglein 3 (pemphigus vulgaris antigen) , desmoglein-3 , 130 kDa pemphigus vulgaris antigen , 130-kD pemphigus vulgaris antigen , cadherin family member 6 , pemphigus vulgaris antigen , 130 kDa pemphigus vulgaris antigen homolog , desmoglein 3 preprotein , desmoglein 3

468511 Pan troglodytes
529902 Bos taurus
1830 Homo sapiens
13512 Mus musculus
291752 Rattus norvegicus
403470 Canis lupus familiaris
705685 Macaca mulatta
100347905 Oryctolagus cuniculus
100590729 Nomascus leucogenys
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