anti-Defensin, alpha 4, Corticostatin (DEFA4) 抗体

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. 再加上,我们可以发Defensin, alpha 4, Corticostatin 试剂盒 (5)Defensin, alpha 4, Corticostatin 蛋白 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DEFA4 1669 P12838
DEFA4 13238 P28311
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Showing 10 out of 54 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Human Breast Cancer Tissue. 100 μL 13至16个工作日
非结合性 ELISA, IHC, WB Western blot analysis of Defensin alpha4 using HuvEc whole cell lysates ABIN6278446 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11至12个工作日
非结合性 IHC (p), WB Immunohistochemistry analysis of Defensin alpha 4 Antibody in paraffin-embedded human heart tissue. Western blot analysis of Defensin alpha 4 antibody at a 1/500 dilution. Lane 1: MCF-7 cell lysate. Lane 2: Mouse spleen tissue extract. Lane 3: Rat spleen tissue extract. 0.1 mg 6至8个工作日
非结合性 ELISA, IHC   100 μL Available
非结合性 IF/ICC, IHC, IP, WB Western blot analysis of recombinant Human DEFa4. IHC-P analysis of Human Skin Cancer Tissue, with DAB staining. 100 μg 11至18个工作日
非结合性 IHC, ELISA   100 μg 2至3个工作日
非结合性 WB   100 μL 11至14个工作日
非结合性 IHC, IHC (p), WB   50 μL 11至14个工作日
非结合性 ELISA, IHC, IHC (p)   50 μL 11至14个工作日
非结合性 IHC (p) Immunohistochemical analysis of paraffin-embedded human heart tissue using DEFA4 polyclonal antibody . 100 μL 11至12个工作日

更多抗Defensin, alpha 4, Corticostatin的相互作用对抗体

Human Defensin, alpha 4, Corticostatin (DEFA4) interaction partners

  1. findings unveil the molecular determinants of HNP4 function, completing the atlas of structure and function relationships for all human neutrophil alpha-defensins.

  2. Three AMP genes, histatin 3 (HTN3), alpha-defensin 4 (DEFA4) and lysozyme C (LYZ), presented different expression levels in periodontitis patients compared with healthy subjects. The relative expression level of DEFA4 appeared to be a protective factor against periodontitis.

  3. DEFA4 displays antimicrobial activity against E. coli, S. faecalis, and C. albicans.

  4. Results indicate that the gene expression of DEFA 1/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 gene expression in pleomorphic adenomas.

  5. DEFA1-3 and DEFA4 mRNA level in peripheral blood cells can be used to identify chronic myeloid leukaemia patients who are at risk of being imatinib-resistant, before initiation of the therapy.

  6. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation.

  7. Crystal structure of HNP-4.

  8. DEFA4 was upregulated in IPF patients with acute exacerbation

Rhesus Monkey Defensin, alpha 4, Corticostatin (DEFA4) interaction partners

  1. Lys-for-Arg substitutions in rhesus myeloid alpha-defensin improved microbicidal activity against certain bacteria

Mouse (Murine) Defensin, alpha 4, Corticostatin (DEFA4) interaction partners

  1. Depleting CRP4 is incompatible with a proper cardiac development and function. CRP4 is a novel antiremodeling factor regulated, at least to some extent, by cardiac cGMP.

  2. Backbone cyclization provides a means for engineeringalpha-defensins to improve their biological activity while providing excellent stability to serum degradation and highlighting the potential of peptide scaffolds for development of novel compounds.

  3. bactericidal activity predominantly affects noncommensal bacteria

  4. MMP-7-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen

  5. the prosegment of Crp4 inhibits Crp4 bactericidal activity by blocking peptide-mediated perturbation of target cell membranes

  6. Crp4 disulfide arrangement confers essential protection from degradation by this critical activating proteinase, allowing antibacterial action.

  7. cryptdin-1 and cryptdin-4 exhibit circadian oscillation

  8. function of the conserved salt bridge in Crp4 is not linked to bactericidal activity or proteolytic stability of the mature peptide.

  9. CRP4 mediates cGMP/PKG stimulation of SM-specific gene expression, and PKG plays an important role in regulating the phenotype of VSMCs

  10. Kinetics of Crp4 translocation coupled with peptide-induced vesicle leakage are reported.

  11. Beta-sheet-containing Crp4 induces membrane permeabilization more effectively than disulfide-null Crp4 by translocating and forming transient membrane defects.

  12. Lys-for-Arg replacements in cryptdin 4 attenuated bactericidal activity

Defensin, alpha 4, Corticostatin (DEFA4) 抗原简介


Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils\; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.

Gene names and symbols associated with DEFA4

  • defensin alpha 4 (DEFA4) 抗体
  • defensin, alpha 4, corticostatin (DEFA4) 抗体
  • defensin, alpha, 4 (Defa4) 抗体
  • Crp4 抗体
  • DEF4 抗体
  • DEFA4 抗体
  • Defa28 抗体
  • Defcr4 抗体
  • HNP-4 抗体
  • HP-4 抗体
  • HP4 抗体

Protein level used designations for DEFA4

corticostatin , defensin, alpha 4, preproprotein , neutrophil defensin 4 , alpha-defensin 4, corticostatin , Paneth cell-specific alpha-defensin 4 , alpha-defensin 4 , alpha-defensin, 28 , defensin related cryptdin 4 , defensin, alpha, 28 , defensin-related cryptdin-4

1669 Homo sapiens
463971 Pan troglodytes
574311 Macaca mulatta
100307026 Equus caballus
13238 Mus musculus
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