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DHX33 encodes a member of the DEAD box protein family. 再加上，我们可以发DEAH (Asp-Glu-Ala-His) Box Polypeptide 33 蛋白 (2)和数多这个蛋白质的别的产品。
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Human Polyclonal DHX33 Primary Antibody for ICC, IF - ABIN251021
Zhang, Forys, Miceli, Gwinn, Weber: Identification of DHX33 as a mediator of rRNA synthesis and cell growth. in Molecular and cellular biology 2011
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DHX33 doublet is due to alternative translation initiation by two in-frame initiation codons. DHX33 translation initiation from either AUG codon happens at equal efficiency. Short DHX33 protein has similar cellular location and functions with full-length DHX33. Leaky scanning normally occurs in DHX33 mRNA translation, which may serve as a safeguard mechanism to ensure optimal DHX33 translation efficiency.
In clinical samples, the expression of Rab1A or DHX33 was reversely correlated with miR-634. Re-expression of Rab1A or DHX33 abrogated the miR-634-mediated inhibition of cell proliferation and migration. Collectively, our data suggest a tumor suppressor role of miR-634 in hepatocellular carcinoma.
High expression of DHX33 is associated with non-Hodgkin's lymphoma and acute myeloid leukemia.
Study demonstrates that DHX33 acts as a direct transcriptional regulator to promote cell cycle progression and plays an important role in driving cell proliferation during both embryo development and tumorigenesis.
Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease.
The results reveal a newly recognized function of DHX33 in mRNA translation initiation, further solidifying its central role in promoting cell growth and proliferation.
Data indicate that DHX33 forms the inflammasome complex with NLRP3 following stimulation with cytosolic RNA.
results directly implicate DHX33 as a crucial player in establishing rRNA synthesis rates in the face of Ras(V12) or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals.
we show the mechanistic importance of DHX33 in rRNA transcription and proliferation
Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability.
results directly implicate DHX33 as a crucial player in establishing rRNA synthesis rates in the face of Ras(V12) or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals
This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants.
DEAH (Asp-Glu-Ala-His) box polypeptide 33
, putative ATP-dependent RNA helicase DHX33
, putative ATP-dependent RNA helicase DHX33-like
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33
, DEAH box protein 33