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Human D Site of Albumin Promoter (Albumin D-Box) Binding Protein (DBP) interaction partners
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the expression of DBP and MAPK in epilepsy patients was upregulated, suggesting a possible pathogenetic role in IE.
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Lean individuals exhibited significant (P < 0.05) temporal changes of core clock (PER1, PER2, PER3, CRY2, BMAL1, and DBP) and metabolic (REVERBalpha, RIP140, and PGC1alpha) genes.
Mouse (Murine) D Site of Albumin Promoter (Albumin D-Box) Binding Protein (DBP) interaction partners
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PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp gene by targeting BMAL1 and CLOCK.
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constitutive Dbp expression plays an important role in mediating hepatic dysfunction under chronic kidney disease. DBP was significantly decreased in 5/6Nx model mice.
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Dbp plays a well-established role in circadian rhythms.
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Expressions of Dbp and Arnt were dampened in the islets of a diabetic model mouse.
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BMAL1 and CLOCK may act as Kamikaze activators, in that they are rapidly degraded once bound to Dbp chromatin.
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In Ccdc80(-/-) mice, expression of the core clock member Arntl/Bmal1 was reduced whereas that of the oscillating transcription factors Dbp and Tef was increased in all tissues examined.
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The daily mRNA expression profiles of the clock and clock-controlled genes Clock, Bmal1, Cry1, Per1, Per2, and Dbp were substantially dampened in the liver and adipose tissue of 10-wk-old ob/ob mice.
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we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure
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CRY1 binding to the Dbp promoter region delayed BMAL1 and CLOCK-mediated transcription of Dbp compared with Rev-Erbalpha
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natural body temperature rhythms can affect circadian gene expression
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mice deficient for all three PAR bZip proteins (DBP,HLF,& TEF) are highly susceptible to generalized spontaneous and audiogenic epilepsies, frequently lethal. Pyridoxal kinase is a target gene of PAR bZip proteins in both liver and brain
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Dbp transcription cycle is paralleled by binding of BMAL1 and CLOCK to multiple extra- and intragenic E boxes.
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The Dbp protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).
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Data show p38 MAPK- and calcium-dependent TNFR1-mediated transient increase of the negative regulator Per1 and an independent decrease of Dbp.
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Data show that the clock knockout mice or mice devoid of dbp/hlf/tef (triple knockout) exhibit significant changes in renal expression of several key regulators of water or sodium balance.
DBP 抗原简介
Antigen Summary
The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes.
Gene names and symbols associated with DBP
- D-box binding PAR bZIP transcription factor (DBP) 抗体
- D-box binding PAR bZIP transcription factor (Dbp) 抗体
- D site albumin promoter binding protein (Dbp) 抗体
- GC, vitamin D binding protein (GC) 抗体
- D site of albumin promoter (albumin D-box) binding protein L homeolog (dbp.L) 抗体
- DABP 抗体
- dbp 抗体
- Gc 抗体
- tef 抗体
Protein level used designations for DBP
D site-binding protein , albumin D box-binding protein , albumin D-element binding protein , albumin D-element-binding protein , D site of albumin promoter (albumin D-box) binding protein , D site of albumin promoter binding protein , tax-responsive enhancer element-binding protein 302 , taxREB302 , D site albumin promoter binding protein , d site albumin promoter-binding protein 1 , VDB , gc-globulin , group-specific component , vitamin D-binding protein , LOW QUALITY PROTEIN: D site-binding protein , D site of albumin promoter (albumin D-box) binding protein L homeolog , thyrotrophic embryonic factor
GENE ID | SPECIES |
---|---|
503577 | Bos taurus |
100192428 | Ovis aries |
1628 | Homo sapiens |
24309 | Rattus norvegicus |
13170 | Mus musculus |
100588181 | Nomascus leucogenys |
100008994 | Oryctolagus cuniculus |
100730328 | Cavia porcellus |
379940 | Xenopus laevis |
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