Cytokine Receptor-Like Factor 1 蛋白 (CRLF1)

CRLF1 encodes a member of the cytokine type I receptor family. 再加上,我们可以发Cytokine Receptor-Like Factor 1 抗体 (63)Cytokine Receptor-Like Factor 1 试剂盒 (33)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CRLF1 9244 O75462
CRLF1 12931 Q9JM58
CRLF1 290655  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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CRLF1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

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Human Cytokine Receptor-Like Factor 1 (CRLF1) interaction partners

  1. From these results we conclude that one should consider a CRLF1-related disorder in early onset achalasia even if other Crisponi or cold-induced sweating syndrome type 1 (CS/CISS1) related symptoms are missing.

  2. we show in this series of 12 patients from four families, all previously unpublished, that the homogeneity of the recently described c.983dupG (p.Ser328Argfs *2) mutation in CRLF1 was associated with a highly variable degree of severity, and that the phenotype significantly overlaps with the recently described COG6 (显示 COG6 蛋白)-related anhidrosis syndrome (MIM (显示 MTSS1 蛋白)#615328

  3. CLF-1, based on its binding site for CLC (显示 CLC 蛋白) and on two additional and independent sites for CNTFRalpha (显示 CNTFR 蛋白) and sorLA (显示 SORL1 蛋白), is a key player in CLC (显示 CLC 蛋白) and CNTFRalpha (显示 CNTFR 蛋白) signaling and turnover.

  4. Article reports 11 novel mutations in CRLF1 expanding the mutational spectrum of CRLF1 in the Crisponi/cold-induced sweating type 1 syndrome to a total of 35 variants.

  5. The mutation detected in CRLF1 has not been described in patients with CISS1, but in one with CS. These data seem to support the theory that CS and CISS1 are variants of the same disorder.

  6. Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130 (显示 IL6ST 蛋白)/JAK (显示 JAK3 蛋白) signaling pathway.

  7. In idiopathic pulmonary fibrosis, CLF-1 is a selective stimulus of type II alveolar epithelial cells and may potentially drive an antifibrotic response by augmenting both T-helper-1-driven and T-regulatory-cell-driven inflammatory responses in the lung.

  8. CRLF1 mutations showed that phenotypic severity of the two disorders: Crisponi syndrome (CS) and cold-induced sweating syndrome type 1 (CISS1) mainly depends on altered kinetics of secretion of the mutated CRLF1 protein.

  9. Our data suggest that the CRLF1/CLC (显示 CLC 蛋白) complex disrupts cartilage homeostasis and promotes the progress of OA by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix

Mouse (Murine) Cytokine Receptor-Like Factor 1 (CRLF1) interaction partners

  1. The p28 (显示 GSTO1 蛋白)/cytokine-like factor 1 (CLF) complex may participate in the regulation of natural killer (NK) and T cell functions by dendritic cells.

蛋白简介Cytokine Receptor-Like Factor 1 (CRLF1)

蛋白简介

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome.

Gene names and symbols associated with CRLF1

  • cytokine receptor like factor 1 (CRLF1)
  • cytokine receptor-like factor 1 (Crlf1)
  • cytokine receptor-like factor 1a (crlf1a)
  • CISS 蛋白
  • CISS1 蛋白
  • CLF 蛋白
  • CLF-1 蛋白
  • clf-1.a 蛋白
  • CRLF1 蛋白
  • CRLM3 蛋白
  • NR6 蛋白
  • NR6.1 蛋白
  • wu:fd24a10 蛋白
  • zcytor5 蛋白
  • zgc:91992 蛋白

Protein level used designations for CRLF1

cytokine receptor-like factor 1 , class I cytokine receptor , cytokine type 1 receptor CRLP-1 , cytokine-like factor 1 , CRLM-3 , NR6 , cytokine receptor like molecule 3 , cytokine receptor-like molecule 3 , novel cytokine receptor 6 , clf-1a , crlf1 , fd24a10

GENE ID SPECIES
720247 Macaca mulatta
735722 Pan troglodytes
9244 Homo sapiens
12931 Mus musculus
290655 Rattus norvegicus
100858730 Gallus gallus
484818 Canis lupus familiaris
100738750 Sus scrofa
511086 Bos taurus
436923 Danio rerio
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