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Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 蛋白 (CYP2E1)

CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes. 再加上，我们可以发Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 抗体 (177) 和 Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 试剂盒 (42)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CYP2E1 1571 P05181
CYP2E1 13106 Q05421
CYP2E1 25086 P05182

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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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Insect Cells 人 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
¥195,007.14
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大肠杆菌（E. Coli） 大鼠 His tag 100 μg Log in to see 13至17个工作日
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小麦胚 人 GST tag 2 μg Log in to see 29至34个工作日
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CYP2E1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,

更多Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1)互动伙伴

Rabbit Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. The localization of CYP1A2 (显示 CYP1A2 蛋白), CYP2B4 and CYP2E1 within the ER was determined by partial membrane solubilization with Brij 98

Human Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. The CYP2E1-PPARalpha (显示 PPARA 蛋白) axis may play a role in ethanol-induced neurotoxicity via the alteration of the genes related with synaptic function

  2. Results demonstrated that CYP2E1*5B and CYP2E1*6 minor alleles play a role in the development of sporadic colorectal neoplasms.

  3. This meta-analysis suggests that there is an increased risk of antituberculosis drug-induced hepatotoxicity in individuals carrying the C1/C1 genotype of the CYP2E1 RsaI/PstI (显示 SPINK1 蛋白) polymorphism; however, no association was found for the DraI polymorphism

  4. NS5A contributes to reactive oxygen species production by activating expression of NADPH (显示 NQO1 蛋白) oxidases 1 and 4 as well as cytochrome P450 2E1.

  5. This meta-analysis suggests that the CYP2E1 polymorphisms contributed to the susceptibility of nasopharyngeal carcinoma, especially in Asian populations.

  6. Study indicate that ALDH2 (显示 ALDH2 蛋白) Glu487Lys and CYP4502E1 polymorphisms could be risk factors for the development of gastric cancer in the Chinese population.

  7. genetic association studies in population in Italy: Data suggest that SNPs in CYP2E1 are associated with differentiated thyroid carcinoma.

  8. CYP2E1 RsaI/PstI (显示 SPINK1 蛋白) polymorphisms may modify the susceptibility to HNC (显示 MMP8 蛋白), particularly among Asians, mixed population, and never-smokers.

  9. CYP2E1 rs2031920 and COMT (显示 COMT 蛋白) rs4680 are not major contributors to lung cancer risk.

  10. Single nucleotide polymorphism in CYP2E1 gene is Associated with Breast Cancer.

Mouse (Murine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. Data, including data from studies in knockout mice, suggest that the oxidative metabolism of 1,2-dichloropropane, a carcinogenic solvent/insecticide, is exclusively catalyzed by Cyp2e1; this biotransformation step is indispensable for manifestation of hepatotoxic effect of the solvent.

  2. Taken together, these results suggested that 1,2-dichloroethane (1,2-DCE (显示 DHCR24 蛋白)) could enhance CYP2E1 protein expression and enzymatic activity, which could cause oxidative damage in liver, serving as an important mechanism underlying 1,2-DCE (显示 DHCR24 蛋白)-induced liver damage

  3. CYP2E1 is important in causing aging-dependent hepatic steatosis, apoptosis and fibrosis possibly through increasing nitroxidative stress.

  4. Our results support a significant role for CYP2E1 as a novel 4-Aminobiphenyl N-oxidizing enzyme in adult mice

  5. Schisandrol B protects against APAP-induced liver injury, potentially through inhibition of CYP2E1/3A11-mediated APAP bioactivation and regulation of the p53 (显示 TP53 蛋白), p21, CCND1 (显示 CCND1 蛋白), PCNA (显示 PCNA 蛋白), and BCL-2 (显示 BCL2 蛋白) to promote liver regeneration.

  6. Studied hepatic stellate cell cytoglobin (显示 CYGB 蛋白) involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1.

  7. Data suggest that expression of Cyp2e1 in adipose tissue can be regulated by dietary factors; here, expression of Cyp2e1 in white adipose tissue is down-regulated in obesity caused by high-fat diet.

  8. The Cyp2e1-null mice displayed a susceptibility to lung toxicity of styrene similar to that of the wild-type animals; however, Cyp2f2-null mice were resistant to styrene-induced pulmonary toxicity.

  9. significant increases in Col1a1 (显示 COL1A1 蛋白), serine/threonine-protein kinase 1, Ctnnb1 (显示 CTNNB1 蛋白), CSRNP1 (显示 CSRNP1 蛋白), Ddit4 (显示 DDIT4 蛋白), Cyp2e1, and Krit1 (显示 KRIT1 蛋白) expressions and great decreases inreceptor D2, Neu1 (显示 NEURL 蛋白), and Dhcr7 (显示 DHCR7 蛋白) expressions following long-term exposure to TiO2 NPs (显示 NPS 蛋白)

  10. ATF4 (显示 ATF4 蛋白) expression in the liver is responsible for the protective effects against high fat diet-induced CYP2E1 expression.

Pig (Porcine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14.

  2. The relationship between a single nucleotide polymorphism of CYP2E1 and boar taint in pork from Belgian swine is reported.

蛋白简介Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1)

蛋白简介

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Gene names and symbols associated with CYP2E1

  • cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1)
  • cytochrome P450 2E1 (CYP2E1)
  • cytochrome P450 2E1 (PTRG_07411)
  • Cytochrome P450 2E1-like (LOC100342572)
  • cytochrome P450 2E1-like (LOC100727914)
  • cytochrome P450 2E1-like (LOC101843716)
  • cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1)
  • CPE1 蛋白
  • Cyp2e 蛋白
  • CYP2E1 蛋白
  • CYPIIE1 蛋白
  • P450-J 蛋白
  • P450C2E 蛋白

Protein level used designations for CYP2E1

cytochrome P450 2E1 , 4-nitrophenol 2-hydroxylase , Cytochrome P450 2E1 , Cytochrome P450 LM3A , Cytochrome P450 isozyme 3A , Cytochrome P450-ALC , Cytochrome P450-J , cytochrome P-450j , CYPIIE1 , cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 , cytochrome P450-J , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , cytochrome P450, 2e1, ethanol inducible , cytochrome P450-ALC , P450-J , P450RLM6 , cytochrome P450 subfamily 2e1 (ethanol-inducible) , cytochrome P450, subfamily 2E, polypeptide 1 , cytochrome P450RLM6 , cytochrome P-450-J , cytochrome P450 CYP2E1

GENE ID SPECIES
100066422 Equus caballus
554344 Felis catus
6345684 Pyrenophora tritici-repentis Pt-1C-BFP
100342572 Oryctolagus cuniculus
100727914 Cavia porcellus
101843716 Mesocricetus auratus
1571 Homo sapiens
415128 Canis lupus familiaris
13106 Mus musculus
25086 Rattus norvegicus
403216 Sus scrofa
282213 Bos taurus
100568285 Ovis aries
678688 Macaca mulatta
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