anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) 抗体

CYP2D6 encodes a member of the cytochrome P450 superfamily of enzymes. 再加上,我们可以发Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 蛋白 (16)Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 试剂盒 (14)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CYP2D6 1565 P10635
CYP2D6    
CYP2D6    
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Showing 10 out of 165 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-CYP2D6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  OVCAR-3 cell lysate CYP2D6 is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells WB Suggested Anti-CYP2D6  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: OVCAR-3 cell lysate  CYP2D6 is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells 100 μL Log in to see 2至3个工作日
$319.00
详细
非结合性 IHC (p), WB Western blot analysis of Cytochrome P450 2D6 using anti- Cytochrome P450 2D6 antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: rat liver tissue lysates,   Lane 2: mouse liver tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti- Cytochrome P450 2D6 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Cytochrome P450 2D6 at approximately 56KD. The expected band size for Cytochrome P450 2D6 is at 56KD. IHC analysis of Cytochrome P450 2D6 using anti- Cytochrome P450 2D6 antibody . Cytochrome P450 2D6 was detected in paraffin-embedded section of mouse intestine tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti- Cytochrome P450 2D6 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Log in to see 4至6个工作日
$280.00
详细
Cow 非结合性 IHC, WB Rabbit Anti-CYP2D6 Antibody  Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X WB Suggested Anti-CYP2D6 Antibody Titration:  2.5ug/ml  Positive Control:  Human Liver 100 μL Log in to see 2至3个工作日
$249.00
详细
非结合性 IP, WB Western blot analysis of Cytochrome P450 2D6 expression in A431 (A), K562 (B), HuvEc (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
非结合性 WB Western blot analysis of Cytochrome P450 2D6 expression in MCF7 (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
非结合性 IP, WB Western blot analysis of Cytochrome P450 2D6 expression in A431 (A), K562 (B), HuvEc (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
非结合性 WB Western blot analysis of Cytochrome P450 2D6 expression in MCF7 (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
大鼠 非结合性 IHC (p), WB Anti-Cytochrome P450 2D6 antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Kidney Tissue Lysate Lane 3: Rat Brain Tissue Lysate 100 μg Log in to see 4至6个工作日
$280.00
详细
非结合性 ELISA, WB Western blot analysis of extracts from 293/HuvEc/MCF-7 cells, using Cytochrome P450 2D6 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 ELISA, WB Western blot analysis of extracts from HT-29 cells, using Cytochrome P450 2D6 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细

引用最多的anti-Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 抗体

  1. Human Polyclonal CYP2D6 Primary Antibody for IHC (p), WB - ABIN658441 : Gao, Zhang, Cui, Akinyi: Comparison of Paeoniflorin and Albiflorin on Human CYP3A4 and CYP2D6. in Evidence-based complementary and alternative medicine : eCAM 2015 (PubMed)

更多抗Cytochrome P450, Family 2, Subfamily D, Polypeptide 6的相互作用对抗体

Human Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) interaction partners

  1. prevalence of CYP2D6*4 1934AA genotype was higher in total HIV patients compared to healthy controls; similarly, CYP2D6*4 1934AA genotype was much more prevalent in HIV patients without hepatotoxicity compared to healthy controls; there was no significant difference in genotype or allele frequencies of CYP2D6*4 1934G/A polymorphism between the patients with hepatotoxicity and those without or healthy controls

  2. CYP2D6 polymorphisms increase vulnerability to tramadol-induced hepatotoxicity.

  3. Hot flash severity during tamoxifen therapy can not be accounted for by CYP2D6 genotype or observed plasma concentration of tamoxifen, 4-hydroxytamoxifen, or endoxifen

  4. found a novel haplotype which involves 100C>T without 4180G>C

  5. There was a significant difference in baseline neuropsychological scores among schizophrenia patients with three genotypes of CYP2D6 rs1135840. Also, rs1135840 showed a significant association with change in scores after risperidone treatment. This reflected a smaller change in GG genotype than C allele carriers; comparison of these two genotype groups gave a significant difference.

  6. The ratio dehydro-aripiprazole/aripiprazole was influenced by CYP2D6 phenotype

  7. results obtained from this study have proven the CYP variants to be immunoreactive and spectrally active and are suitable for use to examine biotransformation and interaction mechanism of the enzymes

  8. In a cohort of schizophrenia inpatients CYP2D6 metabolic activity affects mean AP daily dose only in the presence of DRD2 Taq1A polymorphic allele. CYP2D6 metabolic activity correlates independently from DRD2 Taq1A polymorphism with hospital stay duration. Subpopulation of schizophrenia inpatients with altered CYP2D6 activity (PMs and UMs) carriers of Taq1A polymorphisms needs special attention of clinicians in aligning o

  9. Dacomitinib total (AUCinf) and peak exposures (Cmax) were similar among subjects with different CYP2D6 genotypes.

  10. CYP2D6*4 Polymorphism is associated with drug resistance in Breast Cancer.

  11. Comparisons of pharmacokinetics of 25 substrates CYP2C9, CYP2C19, or CYP2D6 in healthy Chinese and European subjects (classified with same enzyme activity) suggest that, for most substrates, limited interethnic pharmacokinetic differences exist (according to the databases used in this study). (CYP2C9 = cytochrome P450 family 2 subfamily C member 9; CYP2C19 = cytochrome P450 family 2 subfamily C member 19)

  12. TAM metabolism is extremely complex and involves several drug-metabolizing enzymes. Despite having shown a clear gene-exposure effect, CYP2D6 genotype can only partially explain the interindividual variability observed in TAM metabolite levels.

  13. Consensus has yet to be reached on which CYP2D6 and CYP2C19 star alleles to include on pharmacogenetic testing panels and pharmacogenetic results reporting could be considerably improved

  14. CYP2D6 polymorphisms were not associated with hypertension risk.

  15. Results found significant association of C2850T, G1846A and C100T polymorphisms of CYP2D6 with coronary artery disease especially in females of North-West Indian population.

  16. This population-based study does not support the hypothesis that patients with diminished CYP2D6 activity achieve inferior tamoxifen benefit. These contradictory findings suggest that the association between CYP2D6 genotype and tamoxifen treatment efficacy is null or near null, and unlikely to be useful in clinical practice.

  17. The study results indicated the good response pattern was influenced by the concentration of donepezil, but not by APOE and CYP2D6 polymorphisms.

  18. tamoxifen biotransformation to endoxifen is highly dependent on CYP2D6 activity; however, it is unclear whether there is an association between CYP2D6 genotype or endoxifen concentration and tamoxifen efficacy.

  19. even though the available recommendations are against the CYP2D6 screening, the negative results of clinical trials may have been biased by issues in data collection, analysis and interpretation.

  20. CYP2D6 protein and activity levels did not differ significantly between the genotypes (CYP2D6*1/*1, *1/*10, and *10/*10 genotypes) in the small intestine of the Japanese population.

Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6) 抗原简介

蛋白简介

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug\; sparteine and propafenone, both anti-arrythmic drugs\; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population\; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CYP2D6

  • cytochrome P450 family 2 subfamily D member 6 (CYP2D6) 抗体
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) 抗体
  • cytochrome 2D6 (CYP2D6) 抗体
  • cytochrome P450, family 2, subfamily D, polypeptide 6 (cyp2d6-b) 抗体
  • cytochrome P450 family 2 subfamily D member 6 S homeolog (cyp2d6.S) 抗体
  • cytochrome P450 family 2 subfamily D member 6 (cyp2d6) 抗体
  • cytochrome P450 2D6 (CYP2D6) 抗体
  • cytochrome P450 2D6-like (LOC100988273) 抗体
  • CPD6 抗体
  • CYP2D 抗体
  • cyp2d2 抗体
  • CYP2D6 抗体
  • cyp2d6-a 抗体
  • CYP2D7AP 抗体
  • CYP2D7BP 抗体
  • CYP2D7P2 抗体
  • CYP2D8P2 抗体
  • CYP2D42 抗体
  • CYP2DL1 抗体
  • CYPIID6 抗体
  • MGC64445 抗体
  • P450-DB1 抗体
  • P450C2D 抗体
  • P450DB1 抗体

Protein level used designations for CYP2D6

cytochrome P450 2D6 , cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2 , cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 , cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1 , cytochrome P450-DB1 , debrisoquine 4-hydroxylase , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , CYPIID6 , cytochrome P450 CYP2D42 , cytochrome P450, family 2, subfamily D, polypeptide 6 , cytochrome P450 2D6-like

GENE ID SPECIES
1565 Homo sapiens
470228 Pan troglodytes
678691 Macaca mulatta
100500743 Felis catus
379479 Xenopus laevis
446878 Xenopus laevis
548436 Xenopus (Silurana) tropicalis
100568286 Ovis aries
100988273 Pan paniscus
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