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Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 蛋白 (CYP2B6)

CYP2B6, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. 再加上，我们可以发CYP2B6 抗体 (54) 和 CYP2B6 试剂盒 (11)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
大鼠 CYP2B6 CYP2B6 286953 P13107
CYP2B6 1555 P20813

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Insect Cells 人 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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小麦胚 人 GST tag 10 μg Log in to see 29至34个工作日
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HOST_HEK-293 Cells 人 Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 28至34个工作日
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CYP2B6 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,

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Human Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6) interaction partners

  1. It has been established that cytochrome P4502B6 (CYP2B6) is the major isoform catalyzing both ketamine N-demethylation and ketamine metabolism overall in vitro at therapeutic concentrations and clinically.

  2. polymorphism c.516G>T in the CYP2B6 gene and BMI affect the metabolism rate of propofol and may play an important role in the optimisation of propofol anaesthesia

  3. his cross-sectional, pharmacogenetic candidate, gene pilot study recruited 75 patients having minor elective outpatient surgeries. EP was measured with the Clinician Administered Dissociative State Scale. Genetic association of CYP2B6*6 and GRIN2B (显示 GRIN2B 蛋白) (rs1019385 and rs1806191) single-nucleotide polymorphisms and ketamine-induced EP occurrence and severity were tested using logistic and linear regression.

  4. Data suggest that A785G CYP2B6 gene polymorphisms and specific CYP2B6 haplotypes may be a risk factor for the pathogenesis of AML (显示 RUNX1 蛋白), especially secondary AML (显示 RUNX1 蛋白) as well as for the induction of AML (显示 RUNX1 蛋白) chromosomal aberrations.

  5. Results show that CYP2B6 slow metabolizer genotypes were significantly associated with efavirenz induced central nervous system symptoms.

  6. The possible influence of CYP2B6 c.516G>T genetic variant on propofol dose.

  7. Around 450 and 250 mg daily doses might meet EFV dosing needs of HIV-TB infected Ugandans in general and CYP2B6*6/*6 genotypes, respectively.

  8. CYP2B6 polymorphisms were associated with lower and higher plasma concentrations in pregnant and postpartum women.

  9. Analysis of gene-gene interactions with CYP2B6 was particularly useful to reinforce the role of MRP4 and to reveal unknown associations, such as that of DRD3 (显示 DRD3 蛋白).

  10. POR (显示 POR 蛋白) rs2868177 and CYP2B6*6 variants contribute to the interindividual variability in human CYP2B6 activity, which may affect the disposition and interaction of other CYP2B6 substrate drugs

蛋白简介CYP2B6

蛋白简介

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described\; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Gene names and symbols associated with CYP2B6

  • cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6)
  • cytochrome P450, family 2, subfamily B, polypeptide 6 (cyp2b6)
  • cytochrome P450 2B11 (CYP2B6)
  • cytochrome P450, family 2, subfamily b, polypeptide 3 (Cyp2b3)
  • CPB6 蛋白
  • CYP2B 蛋白
  • Cyp2b6 蛋白
  • CYP2B7 蛋白
  • CYP2B7P 蛋白
  • CYP2B11 蛋白
  • CYP2B30 蛋白
  • CYPIIB6 蛋白
  • CYPIIB11 蛋白
  • EFVM 蛋白
  • IIB1 蛋白
  • P450 蛋白

Protein level used designations for CYP2B6

cytochrome P450 2B6 , cytochrome P450 CYP2B30 , cytochrome P450, family 2, subfamily B, polypeptide 6 , cytochrome P450 PBD-2 , cytochrome P450, family 2, subfamily B, polypeptide 11 , CYPIIB3 , cytochrome P450 2B3 , cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 , cytochrome P450IIB3 , 1,4-cineole 2-exo-monooxygenase , cytochrome P450 IIB1

GENE ID SPECIES
678687 Macaca mulatta
494798 Xenopus laevis
474177 Canis lupus familiaris
286953 Rattus norvegicus
1555 Homo sapiens
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