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CFHR4 is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. 再加上，我们可以发Complement Factor H-Related 4 抗体 (22) 和 和数多这个蛋白质的别的产品。
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Next-generation sequencing of the CFH (显示 CFH ELISA试剂盒) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (显示 CFH ELISA试剂盒)-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR4]
Studies indicate that complement factor H (显示 CFH ELISA试剂盒)-related proteins (FHR1 (显示 CFHR1 ELISA试剂盒)-5) may enhance complement activation, with important implications for the role of these proteins in disease.
Factor H (显示 CFH ELISA试剂盒)-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein
Systemic lupus erythematosus were detected in European Americans and African Americans, which could be attributed to an intronic complement regulator factor H (CFH (显示 CFH ELISA试剂盒)) single nucleotide polymorphism (SNP) and an intergenic SNP between CFHR1 (显示 CFHR1 ELISA试剂盒) and CFHR4.
These data reveal the molecular basis of the specific interaction of CFHR4 with native CRP (显示 CRP ELISA试剂盒) and suggest a role for CFHR4 in enhancing opsonization via CRP (显示 CRP ELISA试剂盒) binding.
Association of factor H (显示 CFH ELISA试剂盒) autoantibodies with deletions of CFHR1 (显示 CFHR1 ELISA试剂盒), CFHR3 (显示 CFHR3 ELISA试剂盒), CFHR4, and with mutations in CFH (显示 CFH ELISA试剂盒), CFI (显示 CFI ELISA试剂盒), CD46 (显示 CD46 ELISA试剂盒), and C3 in patients with atypical hemolytic uremic syndrome.
FHR-4A is a new Factor H (显示 CFH ELISA试剂盒)-related protein with a unique domain composition, that is an internal duplication of four CCP (显示 CRYGD ELISA试剂盒) domains FHR-4A provides the first evidence for alternative splicing among Factor H (显示 CFH ELISA试剂盒)-related genes.
These data identify CFHR4 as a novel ligand for native CRP (显示 CRP ELISA试剂盒), and suggest a role for CFHR4 in opsonization of necrotic cells.
This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene.
complement factor H-related protein 4