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The protein encoded by CFHR3 is a secreted protein, which belongs to the complement factor H-related protein family. 再加上，我们可以发CFHR3 抗体 (9) 和 和数多这个蛋白质的别的产品。
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We conclude that the relationship between complement-regulatory proteins CFHR1 (显示 CFHR1 ELISA试剂盒) and CFHR3 and response to anti-CD20 (显示 MS4A1 ELISA试剂盒) mAb therapy varies based on the specific anti-CD20 (显示 MS4A1 ELISA试剂盒) mAb used.
To our knowledge, this is the first evaluation of the involvement of the CFHR3/CFHR1 (显示 CFHR1 ELISA试剂盒) deletion and age-related macular degeneration in CFH (显示 CFH ELISA试剂盒) Y402H polymorphism Brazilian patients.
These data provide evidence that FHR3, which is absent in patients with the autoimmune form of hemolytic uremic syndrome, is involved in B cell regulation
We describe a novel CFH (显示 CFH ELISA试剂盒)/CFHR3 hybrid gene secondary to a de novo 6.3-kb deletion that arose through microhomology-mediated end joining rather than nonallelic homologous recombination. We confirmed a transcript from this hybrid gene and showed a secreted protein product that lacks the recognition domain of factor H (显示 CFH ELISA试剂盒) and exhibits impaired cell surface complement regulation
Next-generation sequencing of the CFH (显示 CFH ELISA试剂盒) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (显示 CFH ELISA试剂盒)-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins.[CFHR3]
Studies indicate that complement factor H (显示 CFH ELISA试剂盒)-related proteins (FHR1 (显示 CFHR1 ELISA试剂盒)-5) may enhance complement activation, with important implications for the role of these proteins in disease.
These results suggest that the combination of quantitative and qualitative variations in the complement proteins encoded by CFH (显示 CFH ELISA试剂盒), CFHR3 and CFHR1 (显示 CFHR1 ELISA试剂盒) genes is key for the association of these haplotypes with disease.
Genetic variants in CFH (显示 CFH ELISA试剂盒), CFHR3, and CFHR1 (显示 CFHR1 ELISA试剂盒) affect complement activation and thereby predispose patients to develop IgA (显示 IgA ELISA试剂盒) nephropathy.
Prompt use of immunosuppressive agents and plasma exchanges are useful for improving outcomes in pediatric patients with anti-complement factor H (显示 CFH ELISA试剂盒)-associated HUS (显示 CFH ELISA试剂盒).
Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH (显示 CFH ELISA试剂盒)/CFHR1 (显示 CFHR1 ELISA试剂盒)-3 and complement factor H (显示 CFH ELISA试剂盒) 479.
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
H factor-like 4
, H factor-like protein 3
, complement factor H-related protein 3