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COL8A1 encodes one of the two alpha chains of type VIII collagen. 再加上，我们可以发COL8A1 抗体 (56) 和 COL8A1 蛋白 (12)和数多这个蛋白质的别的产品。
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Lack of collagen VIII (显示 COX8A ELISA试剂盒) reduces myofibroblast differentiation and fibrosis and promotes early mortality and left ventricle dilatation in response to pressure overload in mice.
Type VIII (显示 COX8A ELISA试剂盒) collagen signals via beta1 integrin and RhoA (显示 RHOA ELISA试剂盒) to regulate MMP-2 (显示 MMP2 ELISA试剂盒) expression and smooth muscle cell migration.
Type VIII (显示 COX8A ELISA试剂盒) collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.
in contrast to diabetic wild-type mice EMT (显示 ITK ELISA试剂盒)-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII (显示 COX8A ELISA试剂盒) may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice
Type VIII (显示 COX8A ELISA试剂盒) collagen significantly modulates the effect of TGF-beta1 (显示 TGFB1 ELISA试剂盒) on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy.
Crystal structure of mouse alpha1(VIII (显示 COX8A ELISA试剂盒))(3) NC1 domain trimer at 1.9 A resolution. Surface of collagen VIII (显示 COX8A ELISA试剂盒) NC1 trimer has three strips of partially exposed aromatic residues, likely involved in supramolecular assemblies.
These data indicate that type VIII (显示 COX8A ELISA试剂盒) collagen plays an important role in glial scar formation during the repair process by astrocytes.
Smooth muscle cells can modify the matrix microenvironment by producing type VIII (显示 COX8A ELISA试剂盒) collagen, using it to overlay type I collagen, and generating a substrate favorable for migration
Downregulation of COL8A1 expression sensitized hepatocarcinoma cells to the action of D-limonene, impeded cell proliferation, and led to decreased invasiveness, indicating that COL8A1 might serve as a target for gene therapy in hepatocarcinoma.
Oxidized phospholipids induce type VIII (显示 COX8A ELISA试剂盒) collagen expression and vascular smooth muscle cell migration.
High COL8A1 level is associated with chronic obstructive pulmonary disease and cancer.
The COL8A1 rs13095226 polymorphism is not associated with nAMD or PCV, which suggesting this gene maybe not a susceptibility gene locus for neovascular age-related macular degeneration (nAMD) or polypoidal choroidal vasculopathy (PCV) in Chinese subjects.
High COL8A1 expression is associated with early loss of kidney function.
Data indicate that complement factor H (CFH (显示 CFH ELISA试剂盒)) R1210C and common variants in COL8A1 and RAD51B plus six genes contribute predictive information for advanced macular degeneration (AMD (显示 AMD1 ELISA试剂盒)) beyond macular and behavioral phenotypes.
The results are consistent with the proposal that rare CNVs play a role in TS aetiology and suggest a possible role for rearrangements in the COL8A1 and NRXN1 (显示 NRXN1 ELISA试剂盒) gene regions.
In addition, eight genes classified as 'second tier' hits in the original study (PAX7 (显示 PAX7 ELISA试剂盒), THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G (显示 GADD45G ELISA试剂盒), NTN1 (显示 NTN1 ELISA试剂盒), RBFOX3 (显示 RBFOX3 ELISA试剂盒) and FOXE1 (显示 FOXE1 ELISA试剂盒)) showed evidence of linkage and association in this replication sample.
The purpose of this study is to evaluate COL8A1 and COL8A2 (显示 COL8a2 ELISA试剂盒) as candidate genes for thin central corneal thickness in human primary open angle glaucoma patients.
The absence of pathogenic mutations identified in the COL8A1 or COL8A2 (显示 COL8a2 ELISA试剂盒) genes in affected members of 15 pedigrees with familial FECD (显示 COL8a2 ELISA试剂盒) (Fuchs endothelial corneal dystrophy) indicates that other genetic factors are involved.
The absence of pathogenic mutations in COL8A1 and COL8A2 (显示 COL8a2 ELISA试剂盒) in patients with keratoconus indicates that other genetic factors are involved in the pathogenesis of this corneal ectatic disorder.
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed.
collagen, type VIII, alpha 1
, collagen alpha-1(VIII) chain
, procollagen type VIII alpha 1
, procollagen, type VIII, alpha 1
, cell proliferation-inducing protein 41
, collagen VIII, alpha-1 polypeptide
, endothelial collagen
, smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64
, alpha 1 type VIII collagen
, collagen VIII
, type VIII collagen alpha 1 chain