Cluster of Differentiation 1e 蛋白 (CD1e)

CD1e encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. 再加上,我们可以发Cluster of Differentiation 1e 抗体 (68)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CD1e 913 P15812
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CD1e 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,

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Human Cluster of Differentiation 1e (CD1e) interaction partners

  1. There was no association between polymorphisms of CD1E genes and the susceptibilities to Guillain-Barre syndrome.

  2. for isoforms CD1b through CD1e, our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices.

  3. The interaction of LAPTM5 with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 might influence the role of CD1e in the presentation of lipid antigens.

  4. Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM) processing for presentation by CD1b to T lymphocytes

  5. in the late endosomes/lysosomes of dendritic cells, the acid pH promotes the binding of lipid antigens to CD1e through increased hydrophobic and ionic interactions

  6. allelic variation in CD1E does not play a major role in determining multifocal motor neuropathy susceptibility.

  7. In Guillain-Barre syndrome, an initially positive association study with polymorphism of CD1A and CD1E genes was not confirmed

  8. CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d.

  9. These data support that CD1e could have evolved to mediate lipid-exchange/editing processes.

  10. CD1A and CD1E polymorphisms contribute to the polygenic susceptibility to multiple sclerosis

  11. CD1E and CD1A genes may be involved in networks which determine susceptibility to multiple sclerosis types RR-MS and PP-MS, respectively.

  12. substitutions lead to amino acid changes at position 73 and 77 of the alpha1 domain in the former and at position 30 of the alpha2 domain in the latter suggesting that the CD1E gene is much more polymorphic than previously assumed.

  13. cellular and biochemical properties of the human and simian CD1e molecules are similar, suggesting that the particular intracellular distribution of CD1e is important for its physiological and/or immunological function

  14. required for processing of the mycobcterial antigens hexamannosylated phosphatidyl-myo-inositols(PIM6); propose that, through this form of glycolipid editing, CD1e helps expand the repertoire of glycolipidic T cell antigens to optimize immune response

  15. Data show that ubiquitination of CD1e appears to trigger its exit from Golgi compartments and its transport to endosomes.

  16. A polymorphism related to the capacity of the CD1E molecule to participate in the immune response to complex glycolipids is discovered in individuals who might display a CD1e-altered immune response to complex glycolipid antigens.

  17. SNPs in CD1A and CD1E were not associated with GBS susceptibility, specific clinical subgroups, anti-ganglioside antibodies, antecedent infections and prognosis.

  18. CD1e propeptide is conserved during evolution, suggesting that it may also optimize the generation of CD1e molecules in other species.

蛋白简介Cluster of Differentiation 1e (CD1e)

蛋白简介

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found\; however, their biological validity has not been determined.

Gene names and symbols associated with CD1e

  • CD1e molecule (CD1E)
  • CD1e molecule (Cd1e)
  • CD1-e 蛋白
  • CD1A 蛋白
  • R2 蛋白

Protein level used designations for CD1e

CD1E antigen, e polypeptide , R2G1 , T-cell surface glycoprotein CD1e, membrane-associated , differentiation antigen CD1-alpha-3 , hCD1e , leukocyte differentiation antigen , thymocyte antigen CD1E , T-cell surface glycoprotein CD1e, soluble , mCD1e

GENE ID SPECIES
913 Homo sapiens
100379271 Cavia porcellus
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