anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) 抗体

The protein encoded by CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. 再加上,我们可以发CPSF6 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CPSF6 432508 Q6NVF9
CPSF6 11052 Q16630
CPSF6 299811  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • 在线下订单

antibodies-online.cn销售最多的anti-CPSF6 抗体

Showing 10 out of 57 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 IF, IHC, WB WB Suggested Anti-CPSF6 Antibody Titration:  0.3125ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate CPSF6 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit Anti-CPSF6 Antibody  Paraffin Embedded Tissue: Human Muscle Cellular Data: Skeletal muscle cells Antibody Concentration: 16.0 ug/ml Magnification: 400X 100 μL 2至3个工作日
小鸡 非结合性 IHC, IHC (p), WB 100 μL 11至14个工作日
小鼠 非结合性 IF, ELISA, WB CPSF6 monoclonal antibody (M10), clone 3F11 Western Blot analysis of CPSF6 expression in HeLa . Immunofluorescence of monoclonal antibody to CPSF6 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11至12个工作日
非结合性 ELISA, WB Western blot analysis of CPSF6 using HT29 whole cell lysates 100 μL 11至12个工作日
小鼠 非结合性 ELISA, WB 100 μg 11至14个工作日
非结合性 WB Western Blot at 1:1000 dilution + Jurkat whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis in Hela cell line lysates (35ug/lane). 400 μL 2至3个工作日
非结合性 WB Western blot analysis of extracts of various cell lines, using CPSF6 antibody. Western blot analysis of extracts of various cell lines, using CPSF6 antibody (ABIN4903368) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s. 100 μL 11至13个工作日
非结合性 IHC, ELISA, WB 100 μL 2至3个工作日
非结合性 IHC, WB CPSF6 antibody was used for immunohistochemistry at a concentration of 16.0 ug/ml to stain Skeletal muscle cells (arrows) in Human Muscle. Magnification is at 400X CPSF6 antibody used at 0.3125 ug/ml to detect target protein. 100 μg 9至11个工作日
非结合性 IF, IHC (p), WB Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human muscle with CPSF6 polyclonal antibody . Immunofluorescent staining of SK-OV-3 cell with CPSF6 polyclonal antibody  under 4 ug/mL working concentration. 100 μL 11至12个工作日

引用最多的anti-CPSF6 抗体

  1. Human Polyclonal CPSF6 Primary Antibody for ICC, IF - ABIN253249 : Fricke, Valle-Casuso, White, Brandariz-Nuñez, Bosche, Reszka, Gorelick, Diaz-Griffero: The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6. in Retrovirology 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal CPSF6 Primary Antibody for IF, ELISA - ABIN524445 : Kim, Yamamoto, Chen, Aida, Wada, Handa, Yamaguchi: Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. in Genes to cells : devoted to molecular & cellular mechanisms 2010 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal CPSF6 Primary Antibody for ICC, IF - ABIN4300333 : De Iaco, Santoni, Vannier, Guipponi, Antonarakis, Luban: TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm. in Retrovirology 2013 (PubMed)
    Show all 2 Pubmed References


Mouse (Murine) Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. Here we report that the CFIm subunits NUDT21/CPSF5 and CPSF6 are highly enriched in mouse male germ cells relative to somatic cells.

Human Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. The crystal structure of the RSLD-TNPO3 complex revealed potential CPSF6 interaction residues, which were confirmed to mediate TNPO3 binding and CPSF6 nuclear import. Both binding and nuclear import were independent of RSLD phosphorylation, though a hyperphosphorylated mimetic mutant failed to bind TNPO3 and mislocalized to the cell cytoplasm

  2. Study shows that the cellular alternative RNA processing factor CPSF6 plays an important role in the ability of NP1 to suppress internal polyadenylation at (pA)p, in influencing viral mRNA export, and, thus, in modulating gene expression of minute virus of canines, a parvovirus.The cellular RNA processing factor CPSF6 interacted with NP1 in transfected cells and participated with NP1 to modulate its effects.

  3. A novel CPSF6-RARG fusion transcript in acute myeloid leukemia.

  4. CPSF6-capsid interactions allow the virus to bypass peripheral heterochromatin and penetrate the nuclear structure for integration.

  5. The authors demonstrate that CFIm functions as an enhancer-dependent activator of mRNA 3' processing. CFIm regulates global alternative polyadenylation by specifically binding and activating enhancer-containing poly(A) sites.

  6. High CPSF6 expression is associated with HIV infections.

  7. we found CPSF6 and all core paraspeckles proteins to be overexpressed in human breast cancer cases and their expression to correlate with poor patient outcomes.

  8. Studies suggest that binding of cleavage factor Im (CFIm) may be one of the earliest steps in promoting formation of an active cleavage complex.

  9. CPSF6 binding to its docking site in HIV-1 capsid leads to the recruitment of CFIm tetramer, suggesting that CFIm mediates CPSF6 function(s) in integration site targeting.

  10. integration targeting proceeds via two distinct mechanisms: capsid-CPSF6 binding directs HIV-1 to actively transcribed euchromatin, where the integrase-LEDGF/p75 interaction drives integration into gene bodies.

  11. NUP153 and CPSF6 have overlapping binding sites, but each makes unique capsid monomers (CA) interactions. Multiple ligands share an overlapping interface in HIV-1 capsid that is lost upon viral disassembly.

  12. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.

  13. study uncovers two opposing CA-dependent functions of CPSF6 in HIV-1 replication in vivo; however, the benefit for binding CPSF6 appears to outweigh the cost, providing support for a vital function of CPSF6 during HIV-1 replication in vivo

  14. CPSF6 binds specifically to a novel proteinprotein interface on the N-terminal domain of HIV-1 capsid protein (CA).

  15. These results suggested that inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6.

  16. Loss-of-function of CFIm68 and CFIm25 leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells.

  17. TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6.

  18. A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly.

  19. Knockdown of CF I(m)68 induced a systematic use of proximal polyadenylation sites, indicating that changes in relative abundance of a single 3' end processing factor can modulate the length of 3' untranslated regions across the transcriptome.

  20. A 9-residue stretch of hydrophobic amino acids in CPSF6 restricts HIV-1 infection through an interaction with capsid.

CPSF6 抗原简介


The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

Gene names and symbols associated with CPSF6

  • cleavage and polyadenylation specific factor 6 (CPSF6) 抗体
  • cleavage and polyadenylation specific factor 6 S homeolog (cpsf6.S) 抗体
  • cleavage and polyadenylation specific factor 6 (cpsf6) 抗体
  • cleavage and polyadenylation specific factor 6 (Cpsf6) 抗体
  • 4733401N12Rik 抗体
  • AI256641 抗体
  • CFIM 抗体
  • CFIM68 抗体
  • CPSF6 抗体
  • HPBRII-4 抗体
  • HPBRII-7 抗体
  • wu:fa22f12 抗体
  • zgc:85819 抗体

Protein level used designations for CPSF6

cleavage and polyadenylation specific factor 6, 68kDa , cleavage and polyadenylation specificity factor subunit 6 , cleavage and polyadenylation specific factor 6, 68 kD subunit , CPSF 68 kDa subunit , cleavage and polyadenylation specificity factor 68 kDa subunit , cleavage factor Im complex 68 kDa subunit , pre-mRNA cleavage factor I, 68kD subunit , pre-mRNA cleavage factor Im (68kD) , pre-mRNA cleavage factor Im 68 kDa subunit , protein HPBRII-4/7

452068 Pan troglodytes
446580 Xenopus laevis
548671 Xenopus (Silurana) tropicalis
100013834 Monodelphis domestica
100220791 Taeniopygia guttata
100589466 Nomascus leucogenys
327069 Danio rerio
432508 Mus musculus
417844 Gallus gallus
11052 Homo sapiens
474441 Canis lupus familiaris
100152191 Sus scrofa
768231 Bos taurus
299811 Rattus norvegicus
100174771 Pongo abelii
anti-CPSF6 (CPSF6) 抗体 精选生产商