anti-Chromatin Assembly Factor 1, Subunit A (p150) (CHAF1A) 抗体

Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008].. 再加上,我们可以发CHAF1A 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CHAF1A 363333  
CHAF1A 10036 Q13111
CHAF1A 27221 Q9QWF0
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antibodies-online.cn销售最多的anti-CHAF1A 抗体

Showing 10 out of 55 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 ICC, IF, IP, WB Immunocytochemistry/Immunofluorescence: CHAF1A Antibody (SS 1 1-13) [ABIN153013] - Immunofluorescent staining of CAF-1-p150 in HeLa cells (Shibahara et al 1999). 0.2 mL Log in to see 7至9个工作日
$418.10
详细
非结合性 ELISA, WB Western blot analysis of extracts from Jurkat cells, using CAF1B Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 IHC (p), IP, IHC, PLA, WB Immunohistochemistry-Paraffin: CHAF1A Antibody [ABIN2616858] - Human colon carcinoma peyer's patch. Antibody used at a dilution of 1:200 (1ug/ml). 0.1 mL Log in to see 7至9个工作日
$559.35
详细
非结合性 ELISA, WB 100 μL Log in to see Available
$181.73
详细
小鼠 非结合性 IF, IHC (p), WB 0.1 mg Log in to see 6至8个工作日
$357.50
详细
非结合性 ELISA, ICC, IF, WB ABIN6274332 staining Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. Western blot analysis of extracts from various samples, using CAF1B Antibody. Lane 1: Mouse cancer treated with blocking peptide. Lane 2: Mouse cancer; Lane 3: mouse brain; 100 μL Log in to see 11至12个工作日
$390.77
详细
小鼠 非结合性 ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 CHAF1A monoclonal antibody (M02), clone 1C2 Western Blot analysis of CHAF1A expression in Hela S3 NE ( (# ABIN394016 ) Dilution: 1:500~1000 100 μg Log in to see 8至11个工作日
$527.50
详细
非结合性 IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: CHAF1A Antibody [ABIN2616869] - Human colon carcinoma peyer's patch. Antibody used at a dilution of 1:200 (1ug/ml). 0.1 mL Log in to see 7至9个工作日
$559.35
详细
非结合性 ELISA, WB   100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 WB Western blot analysis of extracts of various cell lines, using CHAF1A antibody. 200 μL Log in to see 12至14个工作日
$438.90
详细

引用最多的anti-CHAF1A 抗体

  1. Human Monoclonal CHAF1A Primary Antibody for ICC, IF - ABIN153013 : Smith, Stillman: Immunological characterization of chromatin assembly factor I, a human cell factor required for chromatin assembly during DNA replication in vitro. in The Journal of biological chemistry 1991 (PubMed)
    Show all 11 Pubmed References

  2. Human Monoclonal CHAF1A Primary Antibody for ICC, IF - ABIN2668347 : Hoek, Stillman: Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 3 Pubmed References

  3. Monoclonal CHAF1A Primary Antibody for IF, IP - ABIN534079 : Shibahara, Stillman: Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin. in Cell 1999 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal CHAF1A Primary Antibody for ELISA, WB - ABIN564324 : Doe, Nozawa, Hiruma, Yamada, Matsuki, Nakano, Ogasawara, Nakano, Ikeda, Ikegami, Fujishiro, Kawasaki, Ikeda, Amano, Morimoto, Ogawa, Takamori, Sekigawa, Takasaki: Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus. in Lupus 2014 (PubMed)

  5. Human Polyclonal CHAF1A Primary Antibody for IHC (p), IP - ABIN261685 : Li, Xu, Chang, Zheng, Shen, Liu: SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts. in Nature communications 2018 (PubMed)

更多抗CHAF1A的相互作用对抗体

Human Chromatin Assembly Factor 1, Subunit A (p150) (CHAF1A) interaction partners

  1. CHAF1A and PCNA are highly expressed in cervical squamous cell carcinoma and associated with the malignancy

  2. Recent work has identified the chromatin assembly factor complex CAF-1 as a potent barrier to cellular reprogramming. In addition, CAF-1 has been implicated in the reversion of pluripotent cells to a totipotent-like state and in various lineage conversion paradigms, suggesting that modulation of CAF-1 levels may endow cells with a developmentally more plastic state.

  3. Chromatin reassembly during double-strand break repair was dependent on the HIRA histone chaperone that is specific to the replication-independent histone variant H3.3 and on CAF-1 that is specific to the replication-dependent canonical histones H3.1/H3.2.

  4. Data show that the high expression of chromatin assembly factor 1, subunit A (p150) (CHAF1A) promotes cell proliferation and inhibits cell apoptosis, suggesting that CHAF1A may be developed as a prognosis biomarker and potential therapeutic target of epithelial ovarian cancer (EOC).

  5. CHAF1A inhibits NEIL1 initiated repair in vitro Subsequent restoration of the chaperone-BER complex in cell, presumably after completion of repair, suggests that histone chaperones sequester the repair complex for oxidized bases in non-replicating chromatin, and allow repair when oxidized bases are induced in the genome.

  6. Loss of CAF1 is associated with increased motility and invasive phenotypes seen in transformed cells.

  7. These data suggest that CAF-1- and ASF1A-H3-H4-dependent deposition of the histone (H3-H4)2 tetramers is compatible with MMR and protects the discontinuous daughter strand from unnecessary degradation by MMR machinery.

  8. Taken together, these results show that CHAF1A contributes to the proliferation of glioblastoma cells and may be developed as a de novo drug target and prognosis biomarker of glioblastoma.

  9. Novel functions for a separable domain of the p150 protein, regulating protein and DNA interactions at the nucleolus.

  10. The frequency of positive CHAF1A staining in primary tumor mucosa (45.8% of 203 samples) was significantly elevated compared to normal mucosa (18.7% of samples). Increased expression was associated with cancer stage, tumor invasion and histological grade.

  11. Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma.

  12. CAF1 was hijacked by IE2 to facilitate the replication of the HCMV genome, suggesting chromatin assembly plays an important role in herpesviral DNA synthesis, but also provide a model of the virus-induced chromatin instability through CAF1.

  13. CAF-I-dependent control of degradation of the discontinuous strands during mismatch repair.

  14. these findings suggest an expanded role of p150 as a SUMO2/3-interacting factor, and raise the intriguing possibility that p150 plays a role in promoting delivery of SUMO2/3 or SUMO2/3-modified proteins (or both) on chromatin fibers during replication.

  15. p150 was efficiently phosphorylated by Cdc7-Dbf4 kinase.

  16. ACF generates the characteristic 50- to 60-base-pair internucleosomal spacing in silent chromatin by kinetically discriminating against shorter linker DNAs

  17. rs9352 of CHAF1A was repeatedly includes (78% of the 200 bootstrap samples) in the best set of SNPs. CHAF1A may contribute to gliomagenesis.

  18. p150 directly activates transcription, independently of its histone deposition function.

  19. Data show that human CAF-1 (p150) contains two PCNA interaction peptides, and suggest that these peptides are part of the mechanism that enables CAF-1 to function behind replication forks without interfering with other PCNA-mediated processes.

  20. Altered mRNA expression is associated with prostate cancer recurrence.

Mouse (Murine) Chromatin Assembly Factor 1, Subunit A (p150) (CHAF1A) interaction partners

  1. CAF-1 is an essential guardian of the genome in preimplantation mouse embryos.

  2. the histone chaperone CAF-1 to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting

  3. Findings suggest that p150 may link the DNA-bound Gfi1 repressor complex to histones enabling modifications required for transcriptional silencing.

  4. This recruitment is strictly dependent on p150CAF-1, the largest subunit of chromatin assembly factor 1 (CAF-1), and its ability to interact with HP1alpha.

  5. during DNA replication, the interaction of HP1 with p150CAF-1 is essential to promote delivery of HP1 molecules to heterochromatic sites

  6. findings suggest that CAF-1 is required for the maturation of heterochromatin during preimplantation development and that CAF-1 is specifically required for heterochromatin organization in pluripotent embryonic cells

  7. Data show that human CAF-1 (p150) contains two PCNA interaction peptides, and suggest that these peptides are part of the mechanism that enables CAF-1 to function behind replication forks without interfering with other PCNA-mediated processes.

CHAF1A 抗原简介

蛋白简介

Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B\; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995

Gene names and symbols associated with CHAF1A

  • chromatin assembly factor 1 subunit A (Chaf1a) 抗体
  • chromatin assembly factor 1 subunit A (CHAF1A) 抗体
  • chromatin assembly factor 1 subunit A (LOC100447657) 抗体
  • chromatin assembly factor 1, subunit A (p150) (Chaf1a) 抗体
  • chromatin assembly factor 1, subunit A (p150) (chaf1a) 抗体
  • chromatin assembly factor 1 subunit A S homeolog (chaf1a.S) 抗体
  • AL023013 抗体
  • AL024058 抗体
  • Cac1p 抗体
  • CAF-1 抗体
  • CAF-1P150 抗体
  • CAF-I-p150 抗体
  • CAF-Ip150 抗体
  • CAF1 抗体
  • CAF1B 抗体
  • CAF1P150 抗体
  • caip150 抗体
  • CHAF1A 抗体
  • chaf1a-b 抗体
  • P150 抗体
  • wu:fd14g10 抗体
  • xp150 抗体
  • zgc:153930 抗体

Protein level used designations for CHAF1A

chromatin assembly factor 1, subunit A (p150) , chromatin assembly factor 1 subunit A-like , CAF-1 subunit A , CAF-I 150 kDa subunit , CAF-I p150 , chromatin assembly factor 1 subunit A , chromatin assembly factor I (150 kDa) , chromatin assembly factor I p150 subunit , hp150 , CAF-Ip150 , chromatin assembly factor-1p150 , Chromatin assembly factor I p150 subunit , CAF-I 150 kDa subunit B , CAF-I p150-B , CAF-Ip150-B , Chromatin assembly factor I p150 subunit B , chromatin assembly factor 1 subunit A-B

GENE ID SPECIES
363333 Rattus norvegicus
455603 Pan troglodytes
485038 Canis lupus familiaris
100231993 Taeniopygia guttata
100447657 Pongo abelii
100590477 Nomascus leucogenys
10036 Homo sapiens
27221 Mus musculus
504535 Bos taurus
770217 Gallus gallus
563212 Danio rerio
733264 Xenopus laevis
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