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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. 再加上，我们可以发CLIC1 抗体 (101) 和 CLIC1 蛋白 (12)和数多这个蛋白质的别的产品。
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The CLIC1-mediated drug resistance is achieved through positive regulation of MRP1 (显示 MDM4 ELISA试剂盒) in choriocarcinoma.CLIC1 is highly expressed in chemoresistant choriocarcinoma.
Proteomic analysis indicates that CLIC1 promotes tumorgenesis in epithelial ovarian cancer.
CLIC1 is a possible tumor marker for ovarian cancer. Dendritic cells pulsed with MtHsp70 (显示 HSPA9 ELISA试剂盒)-CLIC1 can enhance antitumor immunity against ovarian cancer, providing a novel immune therapeutic strategy.
Either dysfunction or downregulation of CLIC1 can partially decrease the antineoplastic effects of metformin.
The expression of CLIC1 might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of pancreatic ductal adenocarcinomas.
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.
Results indicate that CLIC1 is an important contributor to tumor invasion, metastasis, and angiogenesis.
CLIC1 acts as a putative oncogene (显示 RAB1A ELISA试剂盒) in pancreatic cancer.
Data show that glutamate (显示 GRIN1 ELISA试剂盒) 85 and glutamate (显示 GRIN1 ELISA试剂盒) 228 are pH-sensor residues of chloride intracellular channel protein CLIC1 and contribute to the pH-response stability in different ways.
CLIC1 and CLIC4 (显示 CLIC4 ELISA试剂盒) are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)
Results indicate CLICs (CLIC1, CLIC4 (显示 CLIC4 ELISA试剂盒) and CLIC5 (显示 CLIC5 ELISA试剂盒))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 (显示 NLRP3 ELISA试剂盒) activation.
We conclude that the role of CLIC1 in macrophage superoxide production is to support redistribution of NADPH oxidase (显示 NOX1 ELISA试剂盒) to the plasma membrane, and not through major effects on ERM cytoskeleton or by acting as a plasma membrane chloride channel (显示 CLCA1 ELISA试剂盒).
Data, including data from studies in primary cells from knockout mice, suggest Clic1 and Clic4 (显示 CLIC4 ELISA试剂盒) participate in signaling interleukin 1beta secretion and in activation of Nlrp3 (显示 NLRP3 ELISA试剂盒) inflammasomes; in LPS (显示 TLR4 ELISA试剂盒) macrophage activation, Clic1 and Clic4 (显示 CLIC4 ELISA试剂盒) are translocated to nucleus/cell membranes. (Clic1 = chloride intracellular channel 1; Clic4 (显示 CLIC4 ELISA试剂盒) = chloride intracellular channel 4 (显示 CLIC4 ELISA试剂盒), mitochondrial; Nlrp3 (显示 NLRP3 ELISA试剂盒) = NLR family pyrin domain containing 3 (显示 NLRP3 ELISA试剂盒))
This study demonstrates for the first time that CLIC1 is overexpressed during AS development both in vitro and in vivo and can regulate the accumulation of inflammatory cytokines and production of oxidative stress.
Clic1 have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 (显示 ANXA7 ELISA试剂盒) and Gelsolin (显示 GSN ELISA试剂盒).
These data all point to an important role for CLIC1 in regulating macrophage function through its ion channel activity.
The down-regulation of CLIC1 enhanced proliferative activity.
CLIC1 may play an important role in tumor metastasis.
CLIC1 is essential for the proliferation and invasion of hepatocellular carcinoma cells.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family\; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
chloride intracellular channel 1
, RNCC protein
, chloride channel ABP
, chloride intracellular channel protein 1
, nuclear chloride ion channel 27
, nuclear chloride ion channel protein
, regulatory nuclear chloride ion channel protein