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CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1. 再加上，我们可以发Ceramide Synthase 2 试剂盒 (6) 和 Ceramide Synthase 2 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Monoclonal CERS2 Primary Antibody for ELISA, WB - ABIN526190
Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells. in Anticancer research 2012
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Human Polyclonal CERS2 Primary Antibody for WB - ABIN526188
Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: Bcl2L13 is a ceramide synthase inhibitor in glioblastoma. in Proceedings of the National Academy of Sciences of the United States of America 2014
ASGR1 (显示 ASGR1 抗体) can inhibit the activity of V-ATPase (显示 ATP6V1H 抗体) by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.
Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9 (显示 AGPAT9 抗体)) inhibit cell growth by regulating expression of KLF4 (显示 KLF4 抗体)/LASS2/V-ATPase (显示 ATP6V1H 抗体) proteins in breast cancer.
these results indicate that miR (显示 MLXIP 抗体)-9 upregulation might be associated with malignant phenotype of bladder cancer. miR (显示 MLXIP 抗体)-9 promotes chemoresistance of bladder cancer cells by target LASS2.
Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.
silencing of TMSG1 increased V-ATPase (显示 ATP6V1H 抗体) activity, decreased extracellular pH and in turn the activation of secreted MMP-2 (显示 MMP2 抗体), which ultimately promoted metastasis capacity of breast cancer cell.
Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase (显示 CASP3 抗体)-dependent mitochondrial pathway.
the vacuolar ATPase (V-ATPase (显示 DNAH8 抗体)) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2 (显示 MMP2 抗体)) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1
the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells
Co-expression of CerS2 with CerS4 (显示 CERS4 抗体)/CerS6 (显示 CERS6 抗体) reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.
expression and role of ceramide synthase-2 in the lung
LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy.
Deletion of CerS2 strongly reduced very long-chain ceramides (Cer24:0, 24:1) but concomitantly increased long-chain ceramides and sphinganine in plasma and colon tissue. In naive CerS2(-/-) mice, the expression of tight junction proteins including ZO-1 (显示 TJP1 抗体) was almost completely lost in the colon epithelium, leading to increased membrane permeability. Ceramide synthase 2 deficiency aggravates dextran induced colitis in mice.
this study shows that Cers2 limits the levels of S1P (显示 S1PR1 抗体) in thymus and blood to maintain functional S1P (显示 S1PR1 抗体) gradients that mediate thymocyte emigration into the circulation
that only LCBs, the substrates common for all of the CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in the Cers2-rescued Cers1 (显示 CERS1 抗体) mutant mouse brains.
CerS1 (显示 CERS1 抗体), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (显示 SIRT3 抗体)-null mice.
Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.
Development of pheochromocytoma in ceramide synthase 2 null mice
our data strongly indicate that G-CSF (显示 CSF3 抗体)-induced CXCR2 (显示 CXCR2 抗体) expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.
Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha (显示 TNF 抗体)) secretion as a result of enhanced activity of TNFalpha (显示 TNF 抗体)-converting enzyme (TACE (显示 ADAM17 抗体)).
CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensatio
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.
LAG1 homolog, ceramide synthase 2
, LAG1 longevity assurance 2
, longevity assurance (LAG1, S. cerevisiae) homolog 2
, tumor metastasis-suppressor gene 1 protein
, LAG1 longevity assurance homolog 2
, TRAM homolog 3
, longevity assurance homolog 2
, translocating chain-associating membrane protein homolog 3