anti-Ceramide Synthase 2 (CERS2) 抗体

CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1. 再加上,我们可以发Ceramide Synthase 2 试剂盒 (7)Ceramide Synthase 2 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CERS2 29956 Q96G23
CERS2 76893 Q924Z4
CERS2 310667  
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Showing 10 out of 74 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-LASS2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate CERS2 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL 2至3个工作日
$289.00
详细
Cow 非结合性 IHC, WB WB Suggested Anti-LASS2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human kidney Rabbit Anti-CERS2 Antibody   Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Plasma membrane in intercalated disk Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec 100 μL 2至3个工作日
$289.00
详细
Cow 非结合性 IHC, WB Immunohistochemistry with Human kidney lysate tissue at an antibody concentration of 5.0ug/ml using anti-LASS2 antibody WB Suggested Anti-LASS2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL 2至3个工作日
$319.00
详细
豚鼠 非结合性 IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with LASS2 antibody ABIN462181 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Liver (formalin-fixed, paraffin-embedded) stained with LASS2 antibody ABIN462181 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 100 μL 11至14个工作日
$727.83
详细
Bat 非结合性 WB 100 μL 11至14个工作日
$551.83
详细
豚鼠 非结合性 WB 100 μL 11至14个工作日
$551.83
详细
非结合性 WB 0.1 mg 6至8个工作日
$467.50
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat kidney labeled with Anti-Ceramide synthase 2 Polyclonal Antibody, Unconjugated (ABIN709331) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-Ceramide synthase 2 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3至7个工作日
$329.45
详细
非结合性 WB Western Blot at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lysates/proteins at 20 ug per lane. 200 μL 2至3个工作日
$515.63
详细
小鼠 非结合性 ELISA, WB Western Blot detection against Immunogen (67.32 KDa) . 200 μL 11至12个工作日
$440.00
详细

引用最多的anti-Ceramide Synthase 2 抗体

  1. Human Monoclonal CERS2 Primary Antibody for ELISA, WB - ABIN526190 : Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells. in Anticancer research 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal CERS2 Primary Antibody for WB - ABIN526188 : Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: Bcl2L13 is a ceramide synthase inhibitor in glioblastoma. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)

更多抗Ceramide Synthase 2的相互作用对抗体

Human Ceramide Synthase 2 (CERS2) interaction partners

  1. Study findings suggest that LASS2 inhibits proliferation and induces apoptosis in HepG2 hepatoblastoma cells through the mitochondrial apoptotic, NFkappaB and cell cycle signaling pathways.

  2. results indicate that miR-3622a promotes the proliferation and invasion of bladder cancer cells by downregulating LASS2.

  3. As potential molecular markers for bladder carcinoma, both TWIST1 and LASS2 transcripts seem to play role during the tumorigenesis and development of bladder cancer.

  4. Results show that silencing of ATP6V0C in highly metastatic prostate cancer (PC) cell lines, inhibited V-ATPase activity, which coincided with the inhibition of cell migration and invasion in vitro, as well as a marked decrease in the expression of LASS2/TMSG1 probably through positive feedback.

  5. CerS2-knockdown via CRISPR-Cas9 technology in cultured colon epithelial cells impaired barrier function.

  6. Low expression of LASS2 and TGFB1 contributes to the aggressiveness and poor prognosis of hepatocellular carcinoma, and may represent a novel prognostic biomarker for hepatocellular carcinoma patients.

  7. ASGR1 can inhibit the activity of V-ATPase by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.

  8. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.

  9. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer.

  10. these results indicate that miR-9 upregulation might be associated with malignant phenotype of bladder cancer. miR-9 promotes chemoresistance of bladder cancer cells by target LASS2.

  11. Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.

  12. silencing of TMSG1 increased V-ATPase activity, decreased extracellular pH and in turn the activation of secreted MMP-2, which ultimately promoted metastasis capacity of breast cancer cell.

  13. Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase-dependent mitochondrial pathway.

  14. the vacuolar ATPase (V-ATPase) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1

  15. the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells

  16. Co-expression of CerS2 with CerS4/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.

  17. expression and role of ceramide synthase-2 in the lung

  18. results contribute to the conclusion that LASS2/TMSG1 could regulate V-ATPase activity and intracellular pH through the direct interaction of its homeodomain and the C subunit of V-ATPase

  19. LASS2 expression may be correlated with the development and progression of human bladder carcinoma

  20. LASS2 is involved in chemotherapeutic outcomes and low LASS2 expression may predict chemoresistance.

Mouse (Murine) Ceramide Synthase 2 (CERS2) interaction partners

  1. Our findings indicate that LASS2 plays an important role in the pathogenesis of diet-induced hepatic steatosis

  2. Gene expression analyses in livers of transgenic mouse mutants revealed that inactivation of CerS2 catalytic activity largely affects transcription of genes involved in lipid metabolism and cell division and is associated with the formation of hepatocellular carcinoma in 6 to 8-week-old mice.

  3. Deficiency of CerS2 influences intestinal barrier function and the severity of experimental colitis and may represent a potential mechanism for inflammatory bowel disease pathogenesis.

  4. LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy.

  5. Deletion of CerS2 strongly reduced very long-chain ceramides (Cer24:0, 24:1) but concomitantly increased long-chain ceramides and sphinganine in plasma and colon tissue. In naive CerS2(-/-) mice, the expression of tight junction proteins including ZO-1 was almost completely lost in the colon epithelium, leading to increased membrane permeability. Ceramide synthase 2 deficiency aggravates dextran induced colitis in mice.

  6. this study shows that Cers2 limits the levels of S1P in thymus and blood to maintain functional S1P gradients that mediate thymocyte emigration into the circulation

  7. that only LCBs, the substrates common for all of the CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in the Cers2-rescued Cers1 mutant mouse brains.

  8. CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3-null mice.

  9. These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.

  10. Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.

  11. Development of pheochromocytoma in ceramide synthase 2 null mice

  12. our data strongly indicate that G-CSF-induced CXCR2 expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.

  13. study is the first comparison of spatial distribution between SM molecular species and CerS isoforms, and revealed their distinct association in the brain.

  14. Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha) secretion as a result of enhanced activity of TNFalpha-converting enzyme (TACE).

  15. CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensatio

  16. we first report that Lass2 deficiency caused the downregulation of miR-694 and the upregulation of its target gene Tnfaip3 in vivo in mice, which may be related to a high risk of occurrence of hepatocellular carcinoma

  17. The identification of specific cell types in which CerS2 protein is expressed is prerequisite to further mechanistic characterization of phenotypic abnormalities exhibited by CerS2-deficient mice.

  18. Lass2 is a protective gene against diethylnitrosamine-induced liver tumorigenesis; and upregulation of the TGF-beta1-Smad4-PAI-1 axis may contribute to the vulnerability of Lass2-knockout mice to diethylnitrosamine.

  19. Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.

  20. Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.

Ceramide Synthase 2 (CERS2) 抗原简介

蛋白简介

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.

Gene names and symbols associated with anti-Ceramide Synthase 2 (CERS2) 抗体

  • ceramide synthase 2 (CERS2) 抗体
  • ceramide synthase 2 (Cers2) 抗体
  • 0610013I17Rik 抗体
  • AI225939 抗体
  • L3 抗体
  • Lass2 抗体
  • SP260 抗体
  • TMSG1 抗体
  • TRH3 抗体

Protein level used designations for anti-Ceramide Synthase 2 (CERS2) 抗体

LAG1 homolog, ceramide synthase 2 , LAG1 longevity assurance 2 , longevity assurance (LAG1, S. cerevisiae) homolog 2 , tumor metastasis-suppressor gene 1 protein , LAG1 longevity assurance homolog 2 , TRAM homolog 3 , longevity assurance homolog 2 , translocating chain-associating membrane protein homolog 3

GENE ID SPECIES
100055037 Equus caballus
29956 Homo sapiens
483187 Canis lupus familiaris
539223 Bos taurus
76893 Mus musculus
310667 Rattus norvegicus
100156737 Sus scrofa
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