anti-Cell Adhesion Molecule with Homology To L1CAM (Close Homolog of L1) (CHL1) 抗体

The protein encoded by CHL1 is a member of the L1 gene family of neural cell adhesion molecules. 再加上,我们可以发CHL1 试剂盒 (14)CHL1 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CHL1 10752 O00533
CHL1 12661 P70232
CHL1 89828  
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Showing 10 out of 38 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13至16个工作日
非结合性 WB Western blot analysis of extracts of various cells, using CHL1 antibody. 100 μL Log in to see 16 Days
非结合性 ELISA, WB   100 μL Log in to see 16 Days
小鼠 非结合性 ELISA, WB CHL1 polyclonal antibody (A01), Lot # SAC4060428QCS1 Western Blot analysis of CHL1 expression in Jurkat . Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 11至12个工作日
非结合性 IHC, IHC (p) Immunohistochemistry: CHL-1/L1CAM-2 Antibody [NBP1-86660] - Immunohistochemical staining of human prostate shows strong positivity in peripheral nerves. 0.1 mL Log in to see 10至13个工作日
小鼠 非结合性 ELISA, ELISA (Detection)   100 μg Log in to see 20至21个工作日
非结合性 ELISA   100 μg Log in to see 14至16个工作日
非结合性 IHC (p) Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate with CHL1 polyclonal antibody  shows strong positivity in peripheral nerves at 1:200-1:500 dilution. 100 μL Log in to see 11至12个工作日
非结合性 ELISA, WB Western blot analysis of HL-60 and Jurkat cell lysate, using CHL1 antibody. 100 μg Log in to see 11至16个工作日
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged CHL1 is 0.3 ng/ml as a capture antibody. Western Blot detection against Immunogen (37.84 KDa) . 100 μg Log in to see 11至12个工作日

引用最多的anti-CHL1 抗体

  1. Human Polyclonal CHL1 Primary Antibody for ELISA, WB - ABIN564687 : Ye, Tan, Ponniah, Takeda, Wang, Schachner, Watanabe, Pallen, Xiao: Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha. in The EMBO journal 2008 (PubMed)
    Show all 2 Pubmed References


Human Cell Adhesion Molecule with Homology To L1CAM (Close Homolog of L1) (CHL1) interaction partners

  1. Results indicate that close homolog of L1 protein (CHL1) is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in breast cancer (BC).

  2. CHL1 expression patient-derived lymphoblasts correlated with clinical outcome in depressive disorder patients.

  3. our findings suggest that miR-590-5p acts as an oncogene by targeting the CHL1 gene and promotes cervical cancer proliferation

  4. There was no statistical association between polymorphisms of the CHL1 gene and idiopathic scoliosis in a Chinese population.

  5. Our data collectively indicate that miR (显示 MLXIP 抗体)-182 in PTC (显示 F9 抗体) promotes cell proliferation and invasion through direct suppression of CHL1 (显示 DDX11 抗体), supporting the potential utility of miR (显示 MLXIP 抗体)-182 inhibition as a novel therapeutic strategy against PTC (显示 F9 抗体).

  6. The rs2272522 polymorphism (in the CHL1 gene) was found to exhibit a highly significant association with schizophrenia in the Qatari population.

  7. In 1 of 113 Colombian children with refractory epilepsy, MLPA showed a subtelomeric duplication of exon 3 of CHL1, also present in 2 relatives.

  8. CHL1 has a role in human breast tumorigenesis and progression

  9. The miRNA miR (显示 MLXIP 抗体)-151-3p had 6.7-fold higher basal expression in paroxetine-sensitive LCLs. This corresponds with lower expression of CHL1 (显示 DDX11 抗体), a target of miR (显示 MLXIP 抗体)-151-3p

  10. BACE1(-/-) axon guidance defects are likely the result of abrogated BACE1 processing of CHL1 and BACE1 deficiency produces a CHL1 loss-of-function phenotype

Mouse (Murine) Cell Adhesion Molecule with Homology To L1CAM (Close Homolog of L1) (CHL1) interaction partners

  1. The correlation between the tumor size and the amount of CHL1 secretion could be examined in this study, and showed a significant positive correlation in a tumor size-dependent manner.

  2. investigated temporal discounting in CHL1-deficient (KO) mice and their wild-type littermates. Although no discounting differences were found under baseline conditions, CHL1-KO mice showed increased impulsive choice following chronic unpredictable stress (fewer % larger-later choices, and reduced area under the discounting curve). Impulsive choice alterations were reversed by the 5-HT2C agonist Ro 60 (显示 TROVE2 抗体)-0175.

  3. The results of the present study indicate that CHL1 triggers PTCH1 (显示 PTCH1 抗体)-, SMO-, RhoA (显示 RHOA 抗体)- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development.

  4. These results provide strong support for a 'two-hit' (genes x environment) effect on latent inhibition in CHL1-deficient mice, and identify CHL1-deficient mice as a model of schizophrenia-like learning and attention impairments.

  5. Findings indicate that disrupted-in-schizophrenia 1 (DISC1 (显示 DISC1 抗体)) and close homolog of L1 may engage in physical and functional interaction in neural development, supporting the notion that DISC1 (显示 DISC1 抗体) regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.

  6. results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.

  7. This study provided novel evidence for the functional importance of CHL1 in the post-natal maturation and maintenance of inhibitory circuits and synaptic plasticity in the mouse hippocampus.

  8. homophilic CHL1 transinteractions regulate early differentiation of NSCs. heterophilic transinteractions of CHL1 with vitronectin (显示 VTN 抗体), integrins, and plasminogen (显示 PLG 抗体) activators regulate neuritogenesis and neural cell migration later in cerebellar morphogenesis.

  9. CHL1 is a novel intrinsic factor (显示 GIF 抗体) that is involved in carotid body function and in the ventilatory response to acute hypoxia.

  10. CHL1 endocytosis are required for CHL1-dependent neurite outgrowth.

CHL1 抗原简介


The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.

Gene names and symbols associated with CHL1

  • cell adhesion molecule L1 like (CHL1) 抗体
  • cell adhesion molecule L1-like (Chl1) 抗体
  • A530023M13Rik 抗体
  • AI465420 抗体
  • Call 抗体
  • L1CAM2 抗体
  • LICAM2 抗体

Protein level used designations for CHL1

L1 cell adhesion molecule 2 , cell adhesion molecule with homology to L1CAM (close homolog of L1) , cell adhesion molecule with homology to L1CAM (close homologue of L1) , close homolog of L1 , neural cell adhesion molecule L1-like protein , chl1-like protein , cell adhesion molecule L1-like

10752 Homo sapiens
12661 Mus musculus
89828 Rattus norvegicus
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