Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) ELISA试剂盒

human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006].. 再加上,我们可以发Cdc2-Related Kinase, Arginine/serine-Rich 抗体 (49)Cdc2-Related Kinase, Arginine/serine-Rich 蛋白 (3)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
CRKRS 51755 Q9NYV4
CRKRS 69131 Q14AX6
CRKRS 192350 Q3MJK5
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Fruit Fly (Drosophila melanogaster) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.

  2. CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.

  3. The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.

Human Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation; work clarifies the function of CDK12 and underscores its potential both as a chemotherapeutic target and as a tumour biomarker

  2. CDK12 inhibition in cancer cells lacking CDK12 mutations results in gene length-dependent elongation defects, inducing premature cleavage and polyadenylation (PCPA) and loss of expression of long (>45 kb) genes, a substantial proportion of which participate in Dna Damage Response.

  3. The challenge is to understand CDK12 as a tumor suppressor well enough to explain how it loss promotes cancer development and how it can intercede to prevent or treat those cancers.

  4. CDK12 cooperates with mTORC1, and controls a specialized translation network that is essential for mitotic chromosome stability.

  5. Data suggest that diagnostic IHC quantification of CDK12 in breast cancer is feasible, with CDK12 absence possibly signifying defective DDR function.

  6. CDK12 regulates prereplicative complex assembly to promote mammalian cell proliferation.

  7. CDK12 gene amplification can contribute to the pathogenesis of breast cancer.

  8. BRCA1 downregulation combined with CHK1 inhibition induced excessive amounts of DNA damage, resulting in an inability to complete the S-phase. Therefore, we suggest CHK1 inhibition as a strategy for targeting BRCA1- or CDK12-deficient tumors.

  9. In Ovarian Cancer patients CDK12 loss is consistently associated with a particular genomic instability pattern characterized by hundreds of tandem duplications

  10. Structures of CDK12/CycK complexes solved in the presence of AMP-PNP.

  11. Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK) complex, rendering the kinase inactive.

  12. CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors

  13. CDK12 and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response.

  14. CDK12 plays an important role in cotranscriptional processing of c-FOS transcripts

  15. CDK12 has properties that should confirm interest in its use as a biomarker.

  16. many CDK12 mutations are an unrecognized cause of HR defects in ovarian cancers

  17. CDK12 interacts with cyclin K and is required to maintain embryonnic stem cell self-renewal.

  18. Cyclin K1 is the primary cyclin partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II.

  19. through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability

Mouse (Murine) Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) interaction partners

  1. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation; work clarifies the function of CDK12 and underscores its potential both as a chemotherapeutic target and as a tumour biomarker

  2. Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos.

  3. Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways

  4. The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) 抗原简介

Antigen Summary

human homolog may play a role in regulation of transcription and splicing

Gene names and symbols associated with CRKRS

  • Cyclin-dependent kinase 12 (Cdk12) 抗体
  • cyclin dependent kinase 12 (CDK12) 抗体
  • cyclin-dependent kinase 12 (Cdk12) 抗体
  • 1810022J16Rik 抗体
  • AC017581 抗体
  • AI646528 抗体
  • anon-WO0140519.165 抗体
  • cg7597 抗体
  • Crk7 抗体
  • CRKR 抗体
  • Crkrs 抗体
  • D11Ertd752e 抗体
  • dCDK12 抗体
  • Dmel\\CG7597 抗体
  • gi24668141 抗体
  • hCDK12 抗体
  • Pksc 抗体

Protein level used designations for CRKRS

CG7597-PA , CG7597-PB , CG7597-PC , Cdk12-PA , Cdk12-PB , Cdk12-PC , Cdc2-related kinase, arginine/serine-rich , CDC2-related protein kinase 7 , cell division cycle 2-related protein kinase 7 , cell division protein kinase 12 , CDC2-related kinase 7 , CDC2-related kinase, arginine/serine-rich , protein kinase for splicing component , cyclin-dependent kinase 12 isoform , cyclin-dependent kinase 12 , Cell division protein kinase 12

GENE ID SPECIES
40385 Drosophila melanogaster
100354313 Oryctolagus cuniculus
51755 Homo sapiens
69131 Mus musculus
192350 Rattus norvegicus
511513 Bos taurus
100467815 Ailuropoda melanoleuca
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