CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) ELISA试剂盒

The protein encoded by CDKAL1 is a member of the methylthiotransferase family. 再加上,我们可以发CDKAL1 抗体 (41)CDKAL1 蛋白 (4)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
CDKAL1 54901 Q5VV42
CDKAL1 68916 Q91WE6
大鼠 CDKAL1 CDKAL1 361243  
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适于 CDKAL1 相互作用对的更多 ELISA 试剂盒

Human CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) interaction partners

  1. Forced MT1E (显示 MT1E ELISA试剂盒) expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo.

  2. CDKAL1 gene is associated with development of type 2 diabetes. For the HHEX/IDE (显示 IDE ELISA试剂盒) locus, such an association is absent.

  3. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (显示 PTPRG ELISA试剂盒), OSBPL6, and PDCL3 that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (显示 PTPRG ELISA试剂盒), rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3. In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).

  4. The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX.

  5. Study provides evidence that SNPs of JMJD1C and KCNQ1 (显示 KCNQ1 ELISA试剂盒) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.

  6. Our results suggest that rs6908425 in CDKAL1 is associated with the risk of developing SAPHO in Han Chinese populations. People who carry the risk allele T of rs6908425 might be more prone to developing SAPHO syndrome.

  7. We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO (显示 FTO ELISA试剂盒)) with type 2 diabetes (T2D) in a Uyghur population

  8. our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF therapies among Psoriasis patients

  9. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (显示 ADCY5 ELISA试剂盒), ADRA2A (显示 ADRA2A ELISA试剂盒), CDKAL1, CDKN2A/B, GRB10 (显示 GRB10 ELISA试剂盒), and TCF7L2 (显示 TCF7L2 ELISA试剂盒)

  10. rs10946398 associated with markers of impaired insulin (显示 INS ELISA试剂盒) secretion

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) interaction partners

  1. CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet

  2. Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.

  3. Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (显示 LYZ ELISA试剂盒))(UUU) and that it is required for the accurate translation of AAA (显示 AAAS ELISA试剂盒) and AAG codons.

  4. CDKAL1 controls first-phase insulin (显示 INS ELISA试剂盒) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (显示 CA2 ELISA试剂盒)+) channels through pathways other than CDK5 (显示 CDK5 ELISA试剂盒)-mediated regulation

CDKAL1 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.

Gene names and symbols associated with CDKAL1

  • CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1) 抗体
  • CDK5 regulatory subunit associated protein 1-like 1 (cdkal1) 抗体
  • CDK5 regulatory subunit associated protein 1-like 1 S homeolog (cdkal1.S) 抗体
  • threonylcarbamoyladenosine tRNA methylthiotransferase (LOC587594) 抗体
  • CDK5 regulatory subunit associated protein 1-like 1 (Cdkal1) 抗体
  • 1190005B03Rik 抗体
  • 6620401C13Rik 抗体
  • MGC76088 抗体
  • MGC78779 抗体
  • zgc:65864 抗体

Protein level used designations for CDKAL1

CDK5 regulatory subunit-associated protein 1-like 1 , tRNA-t(6)A37 methylthiotransferase , threonylcarbamoyladenosine tRNA methylthiotransferase , CDK5 regulatory subunit associated protein 1-like 1

100052309 Equus caballus
393600 Danio rerio
394802 Xenopus (Silurana) tropicalis
420823 Gallus gallus
432014 Xenopus laevis
530159 Bos taurus
587594 Strongylocentrotus purpuratus
747778 Pan troglodytes
100024680 Monodelphis domestica
54901 Homo sapiens
488240 Canis lupus familiaris
68916 Mus musculus
361243 Rattus norvegicus
100512355 Sus scrofa
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