Biotin-Protein Ligase (HLCS) ELISA试剂盒

HLCS encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. 再加上,我们可以发Biotin-Protein Ligase 抗体 (30)Biotin-Protein Ligase 蛋白 (5)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
HLCS 110948 Q920N2
HLCS 3141 P50747
大鼠 HLCS HLCS 288240  
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< 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11至18个工作日
小鼠 < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11至18个工作日

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Human Biotin-Protein Ligase (HLCS) interaction partners

  1. The function of HCS and biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, and its participation as a nuclear factor in chromatin dynamics is discussed.

  2. The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1 (显示 HDAC1 ELISA试剂盒), HDAC2 (显示 HDAC2 ELISA试剂盒) and HDAC7 (显示 HDAC7 ELISA试剂盒)

  3. Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1 (显示 NCOR1 ELISA试剂盒)) and HDAC1 (histone deacetylase 1 (显示 HDAC1 ELISA试剂盒)) contribute toward transcriptional repression of repeats, presumably increasing genome stability.

  4. study characterizes three functional promoters in the human HLCS gene

  5. HLCS interacts physically with the DNA methyltransferase (显示 DNMT1 ELISA试剂盒) DNMT1 (显示 DNMT1 ELISA试剂盒) and the methyl CpG binding protein MeCP2 to facilitate the binding of HLCS to chromatin.

  6. This study showed that modification of HSP72 (显示 HSPA1A ELISA试剂盒) and demonstrated that binding of biotin to extracellular HSP72 (显示 HSPA1A ELISA试剂盒) prepares cells for a strong immune response.

  7. individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype

  8. HLCS methionine-58 is a functional translation start site in human cells.

  9. Holocarboxylase synthetase interacts directly with histone H3 (显示 HIST3H3 ELISA试剂盒), causing biotinylation of lysine K9 and K18 (显示 KRT18 ELISA试剂盒).

  10. Mutation analysis by polymerase chain reaction-sequencing of the entire coding region of the HLCS gene revealed the c.1522C>T (p.R508W) mutation in six of the eight mutant alleles. suggests it as the most common mutation in the Thai population

Biotin-Protein Ligase (HLCS) 抗原简介

Antigen Summary

This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with HLCS

  • holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Hlcs) 抗体
  • holocarboxylase synthetase (HLCS) 抗体
  • holocarboxylase synthetase (Hlcs) 抗体
  • 410I21.SP6 抗体
  • D16Jhu34 抗体
  • HCS 抗体
  • RGD1565360 抗体

Protein level used designations for HLCS

biotin apo-protein ligase , biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase , biotin--protein ligase , biotin--[acetyl-CoA-carboxylase] ligase , biotin--[methylcrotonoyl-CoA-carboxylase] ligase , biotin--[methylmalonyl-CoA-carboxytransferase] ligase , holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) , holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

110948 Mus musculus
3141 Homo sapiens
288240 Rattus norvegicus
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