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BMPER encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. 再加上，我们可以发BMPER 试剂盒 (19) 和 BMPER 蛋白 (6)和数多这个蛋白质的别的产品。
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The bone morphogenetic protein- binding protein Cv-2 negatively regulates bone morphogenetic protein signaling.
Cv-2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling.
The NMR structure of the Danio rerio CV2 VWC1 (显示 VWCE 抗体) domain in its unbound state shows the key features for high affinity binding to BMP-2 (显示 BMP4 抗体) are a pre-oriented peptide loop.
Crossveinless 2 functions in a positive-feedback loop to locally enhance BMP activity and is required for neural crest fate determination.
LRP1 (显示 LRP1 抗体) acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 (显示 BMP4 抗体) to mediate the endocytosis of the Bmper/Bmp4 (显示 BMP4 抗体) signaling complex.
Binding of CV2 to Chordin (显示 CHRD 抗体) promotes BMP-2 (显示 BMP4 抗体) signaling.
Cvl2 was identified as an essential pro-bone morphogenetic protein factor during zebrafish embryogenesis.
Bmper is a conserved regulator of hematopoietic and vascular development in zebrafish.
Initial crystallographic analysis suggests that a complete binary complex consisting of one BMP2 (显示 BMP4 抗体) dimer bound to two crossveinless 2 (CV2) von Willebrand type C (VWC1 (显示 VWCE 抗体)) domains is present in the asymmetric unit.
The structure of the complex between CV-2 Von Willebrand factor (显示 VWF 抗体) type C (VWC) domain 1 and BMP-2 (显示 BMP4 抗体), is reported.
CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.
Overexpression of BMPER remarkably enhanced BMP-2 (显示 BMP2 抗体)-induced osteogenic differentiation, while suppression of BMPER effectively inhibited this process both in vitro and in vivo.
that BMPER-modulated BMP pathway activity regulates VE-cadherin (显示 CDH5 抗体) expression and vascular barrier function
BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis.
BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells.
The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 (显示 THBS1 抗体) and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.
these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.
BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs.
Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.
The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER.
Mutual regulation by BMP-9 (显示 GDF2 抗体) and CV2 is essential in regulating the development of the vascular endothelium.
Results identified variant SNPs in BMPER gene associated with phenotypic variation in cattle that can be used as genetic markers for breeding.
BMPER promoter polymorphisms have an effect on the intramuscular fat deposition in longissimus dorsi muscle content.
BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment.
CV2 binds directly to BMP10 (显示 BMP10 抗体), as determined by co-immunoprecipitation, and inhibits BMP10 (显示 BMP10 抗体) from initiating SMAD (显示 SMAD1 抗体) signaling, as determined by luciferase reporter gene assays. BMP10 (显示 BMP10 抗体) and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells.
BMPER/low-density lipoprotein receptor-related protein 1 (显示 LRP1 抗体) axis plays a pivotal role in pulmonary inflammatory response.
BMPER-induced BMP signaling promotes coronary artery remodeling.
BMPER appears to play a role in regulating both vessel density and cardiac development
BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin (显示 CDH1 抗体) and epithelial leakage in vitro and in vivo.
Bmper may play an important role in suppressing hepcidin (显示 HAMP 抗体) production in hypotransferrinemic mice.
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis.
BMP-binding endothelial regulator precursor protein
, BMP binding endothelial regulator
, crossveinless 2
, BMP-binding endothelial regulator protein-like
, BMP-binding endothelial regulator protein
, bone morphogenetic protein-binding endothelial cell precursor-derived regulator