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The protein encoded by BANK1 is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. 再加上，我们可以发BANK1 蛋白 (3)和数多这个蛋白质的别的产品。
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Human Polyclonal BANK1 Primary Antibody for IHC, IHC (p) - ABIN4283023
Bernal-Quirós, Wu, Alarcón-Riquelme, Castillejo-López: BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling. in PLoS ONE 2013
The pre-B-cell receptor (pre-BCR (显示 BCR 抗体)) signaling molecules BLNK (显示 BLNK 抗体), BTK (显示 BTK 抗体) and BANK1 were positively regulated by the ZFP521 (显示 ZNF521 抗体) gene, leading to enhancement of the pre-BCR (显示 BCR 抗体) signaling pathway.
Following CpG stimulation of B-cells, BANK1 loss reduced p38 (显示 CRK 抗体) phosphorylation (but not ERK (显示 EPHB2 抗体) or JNK (显示 MAPK8 抗体)), IL-6 (显示 IL6 抗体) secretion, & MNK1 (显示 MKNK1 抗体)/2 and eIF4E (显示 EIF4E 抗体) phosphorylation. It had no effect on IL-6 (显示 IL6 抗体) mRNA stability. BANK1 does not affect release of eIF4E (显示 EIF4E 抗体) by phospho-4E-BP1 (显示 EIF4EBP1 抗体).
BANK attenuates CD40 (显示 CD40 抗体)-mediated Akt (显示 AKT1 抗体) activation, thereby preventing hyperactive B cell responses.
our results indicated that the BLK (显示 BLK 抗体) rs13277113 polymorphism was involved in the genetic background of RA in Chinese population and the association of BANK1 rs3733197 polymorphism with RA was dependent on the genotype of BLK (显示 BLK 抗体) rs13277113 polymorphism, highlighting B-cell response implicated in the pathogenesis of RA.
This meta-analysis demonstrates that BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms are associated with susceptibility to autoimmune diseases.
Confirm the association of rs548234/ATG5, rs2736340/BLK and rs10516487/BANK1 with systemic lupus erythematosus in Chinese Han and reinforced our hypothesis of their epistasis effect in regulating B-cell signaling in SLE.
The results of this study suggesting a mechanism for the involvement of BANK1 in the BOLD response to working memory
Single-nucleotide polymorphism in BANK1 gene is associated with sclerotic graft-versus-host disease.
The SLE susceptibility variants in the BANK1 gene may contribute to lupus by altering B cell signaling, increasing FOXO1 (显示 FOXO1 抗体) levels, and enhancing memory B cell development
The systemic lupus erythematosus variant Ala71Thr of BLK (显示 BLK 抗体) severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain (显示 ITSN1 抗体) function.
Data show that single-nucleotide polymorphism rs3733197 located in the coding region of BANK1 (B-cell scaffold protein with ankyrin repeats 1) was significantly associated with serum LDL cholesterols.
Authors identified a novel balanced reciprocal translocation, t(4;14)(q24;q32.) Sequence analysis identified the partner gene as BANK1.
Our study confirms evidence for epistasis between BLK (显示 BLK 抗体) and BANK1 in systemic lupus erythematosis from a Chinese population for the first time.
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
B-cell scaffold protein with ankyrin repeats
, B-cell scaffold protein with ankyrin repeats 1
, B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript
, B-cell scaffold protein with ankyrin repeats-like
, b-cell scaffold protein with ankyrin repeats-like