anti-Ataxin 7 (ATXN7) 抗体

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. 再加上,我们可以发和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ATXN7 6314 O15265
ATXN7 246103 Q8R4I1
ATXN7 361015  
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-ATXN7 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: ACHN cell lysate 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB Host: Rabbit  Target Name: Atxn7  Sample Tissue: Rat Small Intestine lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2至3个工作日
非结合性 WB Western blot analysis of Ataxin 7 expression in A549 (A), NIH3T3 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
非结合性 WB 0.1 mL Log in to see 7至9个工作日
豚鼠 非结合性 WB 50 μg Log in to see 11至14个工作日
非结合性 WB ATXN7 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ATXN7 antibody detected the ATXN7 protein (arrow). 400 μL Log in to see 10至11个工作日
非结合性 ELISA, IHC, WB Western blot analysis of ATXN7 using HuvEc whole cell lysates ABIN6279147 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11至12个工作日
非结合性 WB Western blot analysis in CEM cell line lysates (35ug/lane). 400 μL Log in to see 2至3个工作日
小鼠 非结合性 WB   100 μL Log in to see 11至14个工作日
小鼠 非结合性 ICC, IF, IHC, WB   100 μg Log in to see 1至2个工作日

引用最多的anti-ATXN7 抗体

  1. Human Monoclonal ATXN7 Primary Antibody for ICC, IF - ABIN2668230 : Yvert, Lindenberg, Picaud, Landwehrmeyer, Sahel, Mandel: Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. in Human molecular genetics 2000 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal ATXN7 Primary Antibody for WB - ABIN2777891 : Mu, Lin, Chen, Sung, Bai, Jow: The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates. in Pediatrics and neonatology 2009 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal ATXN7 Primary Antibody for WB - ABIN446016 : Fiszer, Wroblewska, Nowak, Krzyzosiak: Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells. in Genes 2016 (PubMed)


Human Ataxin 7 (ATXN7) interaction partners

  1. Genetic testing showed the presence of 48 CAG repeats within one ATXN7 gene for spinocerebellar ataxia type 7 (SCA7).

  2. we observed that carriers of either ATXN7 or TBP alleles with relatively large CAG repeat sizes in both alleles had a substantially increased risk of lifetime depression.

  3. The intronic SNP rs6798742 is associated with ATXN7 CAG-region expansion.

  4. Results identified a chromosomal translocation between Rad51C and Ataxin-7 in colorectal tumors. The in-frame fusion transcript results in a fusion protein with molecular weight of 110 KDa. In vitro 5-Azacytidine treatment of colorectal tumor cells showed expression of the fusion gene is regulated by promoter methylation.

  5. ATXN7 may be a potential predictor of post-operative prognosis of Hepatitis B Virus-related hepatocellular carcinoma .

  6. South American cohort did not confirm the effect of the four candidate loci as modifier of onset age: mithocondrial A10398G polymorphism and CAGn at RAI1, CACNA1A, ATXN3, and ATXN7 genes

  7. Our study provided the clinico-genetic analysis of nine Indian SCA7 families and CAG repeat distribution analysis in diverse Indian populations showed occurrence of ATXN7-CAG intermediate alleles in a predisposed population

  8. Data show that the aggregates formed by polyQ-expanded ataxin 7 sequester ubiquitin-specific protease (USP22) through specific interactions.

  9. Two pathological polyglutamine proteins, truncated Ataxin-7 and full-length Ataxin-3, suggest that accumulation of insoluble aggregates beyond a critical threshold could be responsible for neurotoxicity.

  10. The proband exhibited a typical phenotype of SCA7, which includes cone dystrophy and spinocerebellar ataxia.

  11. Results suggest that sequestration of both enzymatic centers in SAGA upon ATXN7 poly(Q) expansion likely contributes to spinocerebellar ataxia type 7 development and progression.

  12. This study shown evidence in vivo, in the SCA7 KI mouse model, that progressive accumulation of mutant ataxin-7 impairs autophagy.

  13. Epidemiological evidence of a SCA7 founder effect in a Mexican population with spinocerebellar ataxia.

  14. analysis of the founder effect and ancestral origin of the spinocerebellar ataxia type 7 mutation in Mexican families

  15. Haplotype and phylogenetic analyses provide evidence showing that the relatively high frequency of SCA7 in Mexican population is the result of a founder mutation and that Mexican SCA7 carriers possess the Western European ancestry.

  16. polyQ-expanded ataxin-7 directly bound the Gcn5 catalytic core of SAGA while in association with its regulatory proteins, Ada2 and Ada3.

  17. The results demonstrated that a common genetic variant in the ataxia-causing gene ATXN7 influences cerebellar grey matter volume in healthy young adults.

  18. Sequestration of the ponsin splice variant R85FL by the polyglutamine-expanded Atx7 in cell is mediated by the specific SH3C-PRR interaction, which is implicated in the pathogenesis of spinocerebellar ataxia 7.

  19. role of ataxin-7 in differentiation of photoreceptors and cerebellar neurons

  20. Full-length and cleaved fragments of the SCA7 disease protein ataxin-7 (ATXN7) are differentially degraded in a spinocerebellar ataxia type 7 rat model.

Mouse (Murine) Ataxin 7 (ATXN7) interaction partners

  1. Spleen-specific isoform of Pax5 and Ataxin-7 can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.

  2. Results suggest that sequestration of both enzymatic centers in SAGA upon ATXN7 poly(Q) expansion likely contributes to spinocerebellar ataxia type 7 development and progression.

  3. we found that HDAC3 increased the posttranslational modification of normal and expanded ataxin-7.

  4. These results demonstrate that suppression of mutant ataxin-7 expression by only 50% in a polyQ disease model can have a significant impact on disease phenotypes, even when initiated after the onset of detectable behavioral deficits

  5. findings demonstrate that loss of Gcn5 functions can contribute to the time of onset and severity of SCA7 phenotypes, and suggest that non-transcriptional functions of SAGA may play a role in neurodegeneration in this disease

  6. Ataxin-7 gene expression is governed by an antisense ncRNA transcript, SCAANT1, within the ataxin-7 repeat region where the CTCF binding sites reside, which regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription.

  7. polyglutamine-expanded ataxin-7 upregulates the expression of Bax and Puma and causes apoptotic neuronal death by enhancing phosphorylation and transcriptional activity of p53.

  8. study suggests that polyglutamine-expanded ataxin-7-induced transcriptional dysregulation causes cerebellar dysfunction and ataxia

  9. These results demonstrate an influence of SUMOylation on the multistep aggregation process of ATXN7 and implicate a role for ATXN7 SUMOylation in SCA7 pathogenesis.

  10. glutamine expansion stabilizes mutant ataxin-7, provide an explanation for selective neuronal vulnerability, and show that mutant ataxin-7 impairs posttetanic potentiation (PTP).

  11. co-expression of HSP70 with its co-factor HDJ2 efficiently suppressed mutant ataxin-7 aggregation in transfected cells, but did not prevent either neuronal toxicity or aggregate formation in SCA7 mice

  12. We identified a murine SCA7 isoform (SCA7b) containing an uncharacterized exon homologous to the newly identified human exon 12b.

  13. polyQ-expanded ATXN7 deregulated TFTC/STAGA recruitment to a subset of genes specifically expressed in rod photoreceptors, leading to chromatin alterations and consequent progressive loss of rod photoreceptor function

  14. role of cellular stress in neurodegenerative diseases caused by polyglutamine expansion (polyQ) in the context of Spinocerebellar ataxia type 7 (SCA7) that includes retinal degeneration

  15. proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis

ATXN7 抗原简介


The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Ataxin 7 (ATXN7) 抗体

  • ataxin 7 L homeolog (atxn7.L) 抗体
  • ataxin 7 (atxn7) 抗体
  • ataxin 7 (ATXN7) 抗体
  • ataxin 7 (Atxn7) 抗体
  • A430107N12Rik 抗体
  • ADCAII 抗体
  • AI627028 抗体
  • ataxin-7 抗体
  • MGC82940 抗体
  • OPCA3 抗体
  • RGD1562692 抗体
  • Sca7 抗体

Protein level used designations for anti-Ataxin 7 (ATXN7) 抗体

ataxin 7 , ataxin-7 , spinocerebellar ataxia type 7 protein , spinocerebellar ataxia 7 homolog , spinocerebellar ataxia type 7 protein homolog

444398 Xenopus laevis
100127691 Xenopus (Silurana) tropicalis
6314 Homo sapiens
246103 Mus musculus
361015 Rattus norvegicus
416078 Gallus gallus
484701 Canis lupus familiaris
100519688 Sus scrofa
536833 Bos taurus
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