Apelin Receptor (APLNR) ELISA试剂盒

APLNR encodes a member of the G protein-coupled receptor gene family. 再加上,我们可以发Apelin Receptor 抗体 (157)Apelin Receptor 蛋白 (6)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
APLNR 187 P35414
APLNR 23796 Q9WV08
APLNR 83518 Q9JHG3
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大鼠 0.128 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13至16个工作日
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5.8 pg/mL 23.5-1500 pg/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
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5.7 pg/mL 15.625 pg/mL - 1000 pg/mL   96 Tests Log in to see 15至17个工作日
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小鼠 5.9 pg/mL 15.625 pg/mL - 1000 pg/mL   96 Tests Log in to see 15至17个工作日
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小鼠
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引用最多的Apelin Receptor ELISA试剂盒

  1. Rat (Rattus) Apelin Receptor ELISA Kit for Sandwich ELISA - ABIN433383 : Mahmoody, Gharakhanlou, Roshan, Hedayati: Individual and concomitant effects of cardioprotective programs on cardiac apelinergic system and oxidative state in L-NAME-induced hypertension. in Clinical and experimental hypertension (New York, N.Y. : 1993) 2012 (PubMed)

适于 Apelin Receptor 相互作用对的更多 ELISA 试剂盒

Human Apelin Receptor (APLNR) interaction partners

  1. High expression of APJR in hepatocellular carcinoma tissue specimens was related to microvascular invasion, intrahepatic metastasis, and shorter recurrence-free survival after hepatectomy.

  2. Data show that apelin receptor (APJ) I109A mutant receptor retained full capabilities in ligand binding.

  3. we discuss the role of apelin/APJ system in vascular diseases, such as atherosclerosis, hypertension, and chronic kidney disease (CKD) from the point of VSMC. Above all, apelin/APJ system is a promising target for managing vascular disease.

  4. The Apelin/APJ system regulates autophagy, stem cells and the sirtuin family thus contributing to anti-aging.

  5. Stimulation of APJR and its mutants with apelin-13 led to mutation-dependent variation in receptor activation, intracellular Ca(2+)rise, and its subsequent downstream signaling. The mutant (183)MDYS(186)-AAAA in ECL2 showed Gi-biased signaling while (268)KTL(270)-AAA in ECL3 showed Gq biasing. C281A mutant in ECL3 was deficient in all assays.

  6. these data... suggest that APLNR alteration neither by mutation nor expression loss is common in colorectal and prostate cancer

  7. leptin, leptin receptor and apelin receptor genes are associated with susceptibility to coronary artery disease and hypertension

  8. Apelin receptor signaling is critical for endothelial cell polarization.

  9. Studies indicate that the Elabela-APJ (apelin receptor) axis may protect against pressure overload-induced heart failure.

  10. The high APJ expression has significantly higher rates of tumor invasion, local lymph node, and distant metastasis (all p < 0.001).

  11. The mutation of polymorphism rs10501367 in APJ gene decreased risk of hypertension in Chinese males.

  12. these observations suggest apelin-APJ signaling in hepatocytes functions to protect against lipid accumulation in liver through two signaling pathways, that is, via AMPK activation and PPARalpha induction.

  13. 916 ischemic stroke patients were recruited for the study. For age at ischemic stroke onset, no significant association was identified with the variant rs9943582 of APLNR in any genetic model. In addition, the variant was not strongly associated with recurrence and death risk of ischemic stroke, as shown by the results.

  14. the expression of APLNR (APJ/AGTRL1), the only known receptor for apelin, is predominantly restricted to the endothelial cells.

  15. Studies suggest that apelin/APJ system may be applied to the treatment of cancers by regulating apoptosis, which may play a vital role in anticancer therapy [review].

  16. Crystal structure of human APJR shows structural basis for apelin recognition and binding

  17. mutation of promoter polymorphism rs7119375 in APJ gene was significantly associated with elevated SBP and increased hypertension risk in Chinese women.

  18. The APLNR A445C polymorphism was not associated with diabetic retinopathy in a sample of the Tunisian population, but the CC genotype carrier patients with DR had a high total cholesterol concentration.

  19. APLN and APLNR are present in human ovarian cells and APLN increases IGF1-induced steroidogenesis in granulosa cells through an increase in HSD3B protein expression and activation of the MAPK3/1 and Akt pathways. Therefore, APLN and APLNR may play a role in human follicular development and the pathogenesis of PCOS.

  20. These results demonstrate a new pharmacologic property of protamine-blockade of APJ-that could explain some adverse effects observed in protamine-treated patients, and that the established antiangiogenic activity of protamine would rely on APJ antagonism.

Mouse (Murine) Apelin Receptor (APLNR) interaction partners

  1. The study was conducted to determine the effect of DHA on the distribution of apelin and apelin receptor (APJ) in the central nervous system in 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) model.

  2. Activation of Aplnr signaling by Apelin peptide and small molecule ML-233 increased cell movement and expression of migration related gene and proteins including Actin and Vimentin. Similarly, reducing the expression of Aplnr and Apelin (Apln) by siRNA exposure inhibited cell migration of mouse fibroblast cells

  3. the expression of APLNR (APJ/AGTRL1), the only known receptor for apelin, is predominantly restricted to the endothelial cells.

  4. The ELA-APJ axis protects from pressure overload-induced heart failure possibly via suppression of ACE expression and pathogenic angiotensin II signaling.

  5. Internalization does not appear to contribute to the desensitization of APJ-mediated ppERK1/2 activation.

  6. the ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors.

  7. These results demonstrate a new pharmacologic property of protamine-blockade of APJ-that could explain some adverse effects observed in protamine-treated patients, and that the established antiangiogenic activity of protamine would rely on APJ antagonism.

  8. Apelin-36-[L28C(30kDa-PEG)] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ activation

  9. Results show that obese mice had significantly lower mRNA and protein expressions of apelin/ APJ in skeletal muscles than the normal body weight mice.

  10. These results demonstrate that overexpression of APJ in cardiomyocytes has adverse effects on cardiac function in male and non-pregnant mice and that lactation contributes to the development of postpartum cardiomyopathy in the heart with APJ overexpression.

  11. Endothelial CXCR4 is negatively regulated by miR-139-5p, whose transcription is in turn induced by laminar flow and APLN/APLNR signalling.

  12. apelin is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 by apelin receptor(+) ECs

  13. Findings demonstrate a stimulatory role for the islet cell apelin-APJ signaling axis in regulation of pancreatic islet homeostasis and in metabolic induced beta-cell hyperplasia.

  14. ERG and APLNR are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG-APLNR signaling is crucial for the development of pulmonary veno-occlusive disease.

  15. These findings suggest that apelin-APJ signaling is a potential therapeutic target in the treatment of vasculogenic erectile dysfunction.

  16. regulates the Nodal/Bone Morphogenetic Protein antagonist Cerberus and the Baf60c/Smarcd3 subunit of the Brg1/Brm-associated factors (BAF) chromatin-remodelling complex

  17. In obese and insulin-resistant mice, plasma apelin concentration after fasting was not modified but, the gene-expression level of the APL/APJ system was augmented in the white adipose tissue and reduced in the brown adipose tissue, liver and in kidneys.

  18. These findings imply that the pancreatic apelin-APJ system functions to curb the inflammatory and fibrosis responses during pancreatitis, and that apelin reduces inflammation and fibrosis by reducing neutrophil recruitment and PSC activity.

  19. More than half of the expected Apj-/- embryos died in utero because of cardiovascular developmental defects. Apelin-APJ signaling plays a novel role as a potent regulator of endothelial MEF2 function in the developing cardiovascular system.

  20. Apelin-APJ signalling may promote Fas-induced liver injury at least partially via JNK activation.

Cow (Bovine) Apelin Receptor (APLNR) interaction partners

  1. APJ receptor in granulosa cells and both apelin and the APJ receptor in theca tissues are expressed in bovine ovary.

  2. The data suggest that apelin/APJ system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.

Zebrafish Apelin Receptor (APLNR) interaction partners

  1. These results favour a model in which Apelin receptor is required to fine-tune Nodal output, acting as a specific rheostat for the Nodal/TGFbeta pathway during the earliest stages of cardiogenesis.

Xenopus laevis Apelin Receptor (APLNR) interaction partners

  1. Overexpression of Xpreproapelin disorganized the expression of the endothelial precursor cell marker XlFli and the hematopoietic precursor cell marker SCL at the neurula.

  2. study reports that signaling by apelin and its G protein-coupled receptor APJ is essential for embryonic angiogenesis.

Apelin Receptor (APLNR) 抗原简介

Antigen Summary

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.

Gene names and symbols associated with Apelin Receptor (APLNR) ELISA试剂盒

  • apelin receptor (APLNR) 抗体
  • apelin receptor (Aplnr) 抗体
  • apelin receptor (aplnr) 抗体
  • apelin receptor b (aplnrb) 抗体
  • apelin receptor L homeolog (aplnr.L) 抗体
  • agtrl1 抗体
  • agtrl1-A 抗体
  • agtrl1a 抗体
  • agtrl1b 抗体
  • angio1 抗体
  • apj 抗体
  • APJa 抗体
  • apjr 抗体
  • APLNR 抗体
  • aplnr-a 抗体
  • aplnr-b 抗体
  • APLNR1 抗体
  • DKFZp469C1532 抗体
  • grn 抗体
  • hg11 抗体
  • msr 抗体
  • msr/apj 抗体
  • x-MSR 抗体
  • xAngio1 抗体
  • Xmsr 抗体
  • zgc:114063 抗体

Protein level used designations for Apelin Receptor (APLNR) ELISA试剂盒

APJ (apelin) receptor , APJ receptor , G protein-coupled receptor APJ , G-protein coupled receptor APJ , G-protein coupled receptor HG11 , HG11 orphan receptor , angiotensin II receptor-like 1 , angiotensin receptor-like 1 , MSR , B78 , GPCR34 , angiotensin receptor-related protein , apelin receptor , Angiotensin II receptor-like 1b , Angiotensin receptor-like 1b , G-protein coupled receptor APJ B , Protein grinch , angiotensin II receptor-like 1b , angiotensin receptor-like 1b , apelin receptor B , grinch , protein grinch , APJa , Angiotensin receptor-like 1a , Angiotensin receptor-related protein A , G-protein coupled receptor APJ-A , Mesenchyme-associated serpentine receptor , angiotensin receptor related protein , angiotensin receptor-like 1a , angiotensin receptor-related protein A , apelin receptor A , mesenchyme-associated serpentine receptor , apelin receptor 1

GENE ID SPECIES
187 Homo sapiens
23796 Mus musculus
83518 Rattus norvegicus
466585 Pan troglodytes
483497 Canis lupus familiaris
613084 Xenopus (Silurana) tropicalis
615435 Bos taurus
706823 Macaca mulatta
100171470 Pongo abelii
100348126 Oryctolagus cuniculus
565492 Danio rerio
100714001 Cavia porcellus
399306 Xenopus laevis
429337 Gallus gallus
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