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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. 再加上，我们可以发Angiotensin II Receptor-Associated Protein 蛋白 (4) 和 Angiotensin II Receptor-Associated Protein 试剂盒 (3)和数多这个蛋白质的别的产品。
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (显示 AGTR1 抗体), plays a protective role against the development of systemic insulin (显示 INS 抗体) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein (显示 PITPNA 抗体) RdgBbeta (显示 PITPNC1 抗体) binds 14-3-3 (显示 YWHAQ 抗体) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (显示 CSF2 抗体) angiotensin II, ACE (显示 ACE 抗体), and ACE2 (显示 ACE2 抗体) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (显示 AQP4 抗体) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (显示 AGTR1 抗体)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1 (显示 ARAP1 抗体), which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (显示 EPHA3 抗体)-293 cells
CAML (显示 CAMLG 抗体) is an important signal transducer for the actions of Ang II (显示 AGT 抗体) in regulating the calcineurin-NFAT (显示 NFATC1 抗体) pathway and the interaction of CAML (显示 CAMLG 抗体) with ATRAP may mediate the Ang II (显示 AGT 抗体) actions in vascular physiology
Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin (显示 INS 抗体) resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling.
Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Identify Atrap as a novel regulatory protein (显示 TGFB1 抗体) of the cardiac Ca(2+)-ATPase SERCA2a (显示 CA-P60A 抗体). Suggest that Atrap enhances the activity of SERCA2a (显示 ATP2A2 抗体) and, consequently, facilitates ventricular relaxation.
These results suggest that increased formation of AT1R-P2Y6R (显示 P2RY6 抗体) heterodimers with age may increase the likelihood of hypertension induced by Ang II (显示 AGT 抗体).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury.
The inhibition of degradation of angiotensin II type 1 receptor (显示 AGTR1 抗体)-associated protein (显示 BCAP31 抗体) (ATRAP) and inactivation of AT1R-mediated p38 MAPK (显示 MAPK14 抗体) and STAT3 (显示 STAT3 抗体) signaling pathways, are involved cardiac hypertrophy.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I