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Abeta encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. 再加上，我们可以发beta Amyloid 抗体 (274) 和 和数多这个蛋白质的别的产品。
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This is the first evidence of cortical calcification in patients with an APP (显示 APP ELISA试剂盒) mutation other than the Iowa mutation.
Abeta (显示 APP ELISA试剂盒)*56 activated Ca(2 (显示 CA2 ELISA试剂盒)+)-dependent calmodulin kinase II (显示 CAMK2 ELISA试剂盒) and increased site-specific phosphorylation and missorting of tau, both of which are associated with Alzheimer's disease pathology.
data point to a scenario where neuroinflammatory processes together with direct synaptotoxic effects are caused by posttranslational modification of soluble oligomeric Abeta (显示 APP ELISA试剂盒) and contribute synergistically to the onset of synaptic dysfunction in Alzheimer's disease
xplored structural details of fibrils formed by a mutated amyloid beta (Abeta (显示 APP ELISA试剂盒)(1-40)) peptide carrying a Phe19 to Lys19 mutation. Although morphologically very robust, local perturbations of the Abeta (显示 APP ELISA试剂盒)(1-40) sequence lead to moderate structural alterations with tremendous impact on the physiological importance of these aggregates, which may suggest alternative strategies for the development of a remedy against Alzheimer'...
Data show that the positron emission tomography (PET) signal of the (18)F-labelled tracer florbetaben binds to amyloid-beta plaques inversely correlates with CSF (显示 CSF2 ELISA试剂盒) levels of amyloid peptide Ass42, which is a biomarker for Alzheimer's disease (AD).
this study presents the structure of an Abeta (显示 APP ELISA试剂盒)(1-42) fibril composed of two intertwined protofilaments determined by cryo-electron microscopy to 4.0-angstrom resolution, complemented by solid-state nuclear magnetic resonance experiments.
Data, including data from studies using cadaver tissue, suggest that matriptase (显示 ST14 ELISA试剂盒) and matriptase (显示 ST14 ELISA试剂盒) mRNA are expressed in several regions of the brain with an enrichment in neurons; higher levels of matriptase (显示 ST14 ELISA试剂盒) RNA are expressed in young individuals as compared to older individuals; matriptase (显示 ST14 ELISA试剂盒) cleaves amyloid beta precursor protein at a specific arginine residue (Arg-102).
Overexpression of SNX7 in HEK293T cells reduces the levels of secreted Abeta (显示 APP ELISA试剂盒) and beta-cleaved N-terminal APP (显示 APP ELISA试剂盒) fragments (sAPPbeta). Moreover, SNX7 overexpression caused a significant reduction of the steady-state levels of APP (显示 APP ELISA试剂盒) as well as of the cell surface APP (显示 APP ELISA试剂盒) levels.
modulation of proteostasis is a distinct biological function of sAPPalpha and does not require surface-bound holo-APP (显示 APP ELISA试剂盒).
elevated levels of plasma homocysteine /homocysteine thiolactone contribute to AD pathology via the Abeta (显示 APP ELISA试剂盒)-fibrin(ogen) interaction
Conducted in vivo extracellular recording to investigate cholinergic compound action potentials of the superior cervical ganglion (SCG) in APP (显示 APP ELISA试剂盒)(-/-) and littermate wild-type (WT) mice; found that APP (显示 APP ELISA试剂盒) not only regulates presynaptic activity, but also affects postsynaptic function at cholinergic synapses in SCG; also alpha4beta2 and alpha7 nicotinic acetylcholine receptors are reduced in the absence of APP (显示 APP ELISA试剂盒).
App (显示 APP ELISA试剂盒)-KI mouse lines with different levels of pathophysiology are useful models of AD.
Loss of Abpp (显示 APP ELISA试剂盒) is associated with cognitive impairment.
long term survival and amyloid protein (显示 IAPP ELISA试剂盒) levels are modified by positive and negative early life experiences in a mouse model of Alzheimer's disease
the synaptic localization of APP (显示 APP ELISA试剂盒), ADAM10 (显示 ADAM10 ELISA试剂盒), and BACE1 (显示 BACE ELISA试剂盒) in the mouse cerebral cortex, was examined.
Taken together, these results suggest that apoE (显示 APOE ELISA试剂盒)-containing discoidal HDLs (显示 CSF1R ELISA试剂盒) do not require LCAT (显示 LCAT ELISA试剂盒)-dependent maturation to mediate efficient Abeta (显示 APP ELISA试剂盒) clearance
APP (显示 APP ELISA试剂盒) knockout mice have shorter dendritic arbors in the hippocampus.
This study demonstrates the neuroprotective effect of TSG (显示 TWSG1 ELISA试剂盒) on APP (显示 APP ELISA试剂盒) expression, suggesting that TSG (显示 TWSG1 ELISA试剂盒) may be beneficial for AD prevention and treatment.
SNX15 regulates the recycling of APP (显示 APP ELISA试剂盒) to cell surface and, thus, its processing for Abeta (显示 APP ELISA试剂盒) generation.
Immunohistochemical analysis confirmed increased amount of NOS1 (显示 NOS1 ELISA试剂盒) protein in neuronal somata and processes in the perilesional cortex in APP (显示 APP ELISA试剂盒)/PS1 (显示 PSEN1 ELISA试剂盒)-severe traumatic brain injury(TBI) mice compared to APP (显示 APP ELISA试剂盒)/PS1 (显示 PSEN1 ELISA试剂盒)-sham (p < 0.05) or Wt-sTBI mice (p < 0.01).
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
alzheimer disease amyloid protein
, amyloid beta A4 protein
, beta-amyloid peptide
, cerebral vascular amyloid peptide
, peptidase nexin-II
, protease nexin-II
, amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease)
, amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)
, beta-amyloid precursor protein
, alzheimer disease amyloid A4 protein homolog
, amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
, amyloid A4
, amyloidogenic glycoprotein
, protease nexin II