Alkaline Phosphatase, Liver/bone/kidney (ALPL) ELISA试剂盒

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). 再加上,我们可以发ALPL 抗体 (219)ALPL 蛋白 (19)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
ALPL 249 P05186
ALPL 11647 P09242
ALPL 25586 P08289
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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
小鼠 0.063 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13至16个工作日
$720.00
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大鼠 0.3 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests Log in to see 13至16个工作日
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0.3 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests Log in to see 13至16个工作日
$700.00
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豚鼠 0.1 U/L 1.0-25 U/L   96 Tests Log in to see 15至18个工作日
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0.1 U/L 1.0-25 U/L   96 Tests Log in to see 15至18个工作日
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绵羊 3.9 15.6 Typical standard curve 96 Tests Log in to see 13至16个工作日
$1,026.67
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0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 15至18个工作日
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Pig
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0.1 U/L 1.0-25 U/L   96 Tests Log in to see 15至18个工作日
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小鸡
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引用最多的ALPL ELISA试剂盒

  1. Mouse (Murine) ALPL ELISA Kit for Sandwich ELISA - ABIN415660 : Wu, Lin, Liou, Lu, Chen, Fu, Yang: Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-?B activation. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2013 (PubMed)
    Show all 5 Pubmed References

  2. Rat (Rattus) ALPL ELISA Kit for Sandwich ELISA - ABIN416228 : Gradosova, Zivna, Svejkovska, Palicka, Tichy, Zivny: The role of atorvastatin in bone metabolism in male albino Wistar rats. in Die Pharmazie 2011 (PubMed)
    Show all 4 Pubmed References

  3. Rat (Rattus) ALPL ELISA Kit for Competition ELISA - ABIN580965 : Abuohashish, Al-Rejaie, Al-Hosaini, Parmar, Ahmed: Alleviating effects of morin against experimentally-induced diabetic osteopenia. in Diabetology & metabolic syndrome 2013 (PubMed)
    Show all 2 Pubmed References

  4. Mouse (Murine) ALPL ELISA Kit for Sandwich ELISA - ABIN454579 : Williams, Maecker, French, Liu, Gregg, Silverstein, Cao, Carano, Dixit: USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. in Cell 2011 (PubMed)

适于 ALPL 相互作用对的更多 ELISA 试剂盒

Human Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. a significant proportion of adult heterozygotes for ALPL mutations may have unspecific symptoms not attributable to their heterozygosity.

  2. The ALPL SNP, rs1256328, was identified as being significantly associated with kidney stone disease status in a large Chinese Han cohort

  3. The expression of ALP mRNA and ALP activity in bone tissue were much higher in osteoporosis patients with fracture than those without fracture.

  4. genu varum is associated with the alkaline phosphatase level regardless of the presence of radiographic abnormalities in the growth plate in children.

  5. Adults with persistent hypophosphatasemia frequently harbor alkaline phosphatase mutations and have elevated ALP substrates.

  6. Mutations in ALPL which reduce alkaline phosphatase activity are responsible for Hypophosphatasia , a rare disorder characterized by defective bone and teeth mineralization and early tooth loss.

  7. ALDH appears to be involved in the interaction between lung and Osteosarcoma (OS) cells, and ALP may be a valuable biomarker for monitoring functional OS changes during metastasis.

  8. These results show that an increase of TNAP activity in ACDC (arterial calcification due to deficiency of CD73) contributes to ectopic calcification by disrupting the extracellular balance of PPi and Pi and identify potential therapeutic targets for ACDC.

  9. the identification of 11 novel ALPL mutations in the five different HPP forms and the observation of a recurrent mutation, p. (Thr166Ile) in the Spanish population expand our knowledge of pathogenic ALPL mutations.

  10. Preoperative calcitonin levels were correlated with the presence of tumor, whereas alkaline phosphatase (ALP) levels were not. There were no significant associations between tumor volume and ALP or calcitonin levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP was significantly associated with tumor recurrence, but serum calcitonin was not.

  11. His ALPL gene mutation came from c.228delG mutation in his mother and c.407G>A compound heterozygous mutation in his father

  12. Both PPARgamma gene expression and TNALP activity increased during intracellular lipid accumulation in HepG2 and 3T3-L1 cells. Inhibition of TNALP blocked intracellular lipid accumulation but did not alter expression of the PPARgamma gene.

  13. ALPL is a major contributor to the pathogenesis of Prostate cancer progression.

  14. This result indicated that the 1559delT mutant was not retained on the plasma membrane owing to a lack of the Glycosylphosphatidylinositol anchor.

  15. ALPL expression is significantly upregulated in human masticatory mucosa during wound healing

  16. serum ALP levels were not associated with increased death risk in prevalent HD patients over a 5-year interval.

  17. In conclusion, serum levels of BSP, ALP, ICTP, and PSA increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.

  18. results reveal that the amino acid substitutions at position 426 of TNSALP differentially affect the structure and function of TNSALP, leading to understanding of the molecular and cellular basis of hypophosphatasia.

  19. One-half of adult individuals with unexplained low serum ALP carried an ALPL mutation. The presence of a mutated allele was associated with tooth loss, slightly lower levels of serum ALP, higher levels of pyridoxal phosphate and phosphoethanolamine, as well as mildly increased serum phosphate.

  20. Dynamic changes of ALP, LDH and PSA during Abiraterone-therapy are associated with best clinical benefit and OS in bone metastatic castration resistant prostate cancer

Mouse (Murine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. intestinal alkaline phosphatase knockout mice display higher intestinal Ca uptake, which over time appears to correlate with a positive effect on the biomechanical properties of trabecular bone.

  2. Study results from cerulein induced pancreatitis model in TNAP+/- mice show that altered TNAP expression results in heightened pancreatic inflammation, which may be explained by an augmented response of neutrophils and by a higher sensitivity of acinar cells to cerulein injury.

  3. TNAP activation in vascular smooth muscle cells (VSMCs) appears sufficient to induce calcification. TNAP activation in VSMCs stimulates expression of chondrocyte markers.

  4. Our results offer clear evidence that TNAP modulates T lymphocyte function and specifically T cell-dependent colitis.

  5. The results are the first to demonstrate a role for ENC1 in the control of osteoblast differentiation. Additionally, the contrasting mineralization phenotypes and transcriptional patterns seen with coordinate knockdown of both ENC1 isoforms vs selective knockdown of 67 kDa ENC1 suggest opposing roles for the isoforms in regulation of osteoblastic differentiation, through effects on Alpl expression and phosphate cellular

  6. TNAP overexpression in vascular endothelium in mice leads to an unusual course of coronary atherosclerosis and was accompanied by the reduction in body weight and left ventricular ejection fraction.

  7. Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 plays role in enamel formation; Med1 induces Alpl via stimulation of Notch1 signaling by forming Notch1-RBP-Jk complex on Alpl promoter. (Med1 = mediator complex subunit 1; Alpl = alkaline phosphatase, liver-bone-kidney; Notch1 = Notch gene homolog 1; RBP-Jk = kappa J region recombining binding protein suppressor of hairless)

  8. These analyses revealed that TNAP deficient mice present an increased proliferation of neural precursors, an altered neuronal morphology, and an augmented neuronal activity. We found that these alterations were associated with a partial downregulation of the purinergic P2X7 receptor (P2X7R).

  9. Despite similar deficiencies in alkaline phosphatase, Alpl(-/-) mice develop craniosynostosis and a brachycephalic/acrocephalic craniofacial shape of variable penetrance.

  10. Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.

  11. TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.

  12. In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2.

  13. p107 is required for the efficient recruitment of an activating SWI/SNF chromatin-remodeling complex, an essential event in Alpl induction.

  14. Inhibition of rhBMP-2-induced ALP activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.

  15. Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP, including true bony craniosynostosis in the context of severely diminished bone mineralization

  16. CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.

  17. TNAP plays a role in governing the phosphorylation status of phospholamban in the sarcoplasmic reticulum.

  18. Taken together, these data indicate that ATF3 is a novel negative regulator of osteoblast differentiation by specifically suppressing ALP gene expression in preosteoblasts.

  19. data suggest that the promineralization role of TNAP may be related not only to its accepted pyrophosphatase activity but also to its ability to modify the phosphorylation status of OPN.

  20. mineralization abnormalities of dentin; reduced overall mineralization with decreased matrix vesicle mineralization in the Phospho1(-/-) mice; almost complete absence of matrix vesicles in mice; further reduction in mineralization.

Cow (Bovine) Alkaline Phosphatase, Liver/bone/kidney (ALPL) interaction partners

  1. The peri-partum characteristics of serum bone-specific alkaline phosphatase (BAP) and urinary deoxypyridinoline (DPD) in dairy cattle are reported.

  2. GPI-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.

  3. Reliable and reproducible estimates of k(cat) and K(m) from only two or three progress curves were obtained using alkaline phosphatase.

  4. Results indicate that the presence of glycosylphosphatidylinositol increases the stability of alkaline phosphatase against chemical denaturation while it decreases its refolding yield by the artificial chaperone refolding technique.

ALPL 抗原简介

Antigen Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ALPL

  • alkaline phosphatase, liver/bone/kidney L homeolog (alpl.L) 抗体
  • alkaline phosphatase, liver/bone/kidney (ALPL) 抗体
  • alkaline phosphatase, intestinal, gene 2 (alpi.2) 抗体
  • alkaline phosphatase, liver/bone/kidney pseudogene (LOC100031702) 抗体
  • alkaline phosphatase, liver/bone/kidney (Alpl) 抗体
  • Akp-2 抗体
  • Akp2 抗体
  • ALP 抗体
  • alpl 抗体
  • AP-TNAP 抗体
  • APTNAP 抗体
  • HOPS 抗体
  • iap 抗体
  • PHOA 抗体
  • TNAP 抗体
  • TNS-AP 抗体
  • TNSALP 抗体

Protein level used designations for ALPL

tissue-nonspecific alkaline phosphatase , alkaline phosphatase, tissue-nonspecific isozyme , tissue non-specific alkaline phosphatase , alkaline phosphatase, liver/bone/kidney , alkaline phosphatase, tissue-nonspecific isozyme-like , alkaline phosphatase liver/bone/kidney isozyme , alkaline phosphomonoesterase , glycerophosphatase , liver/bone/kidney-type alkaline phosphatase , tissue-nonspecific ALP , alkaline phosphatase 2, liver , AP-TNAP , TNSALP , Tissue-nonspecific ALP alkaline phosphatase , alkaline phosphatase tissue non-specific isoform , liver/bone/kidney isozyme

GENE ID SPECIES
380589 Xenopus laevis
403548 Canis lupus familiaris
717809 Macaca mulatta
100144722 Xenopus (Silurana) tropicalis
100401643 Callithrix jacchus
100440770 Pongo abelii
100031702 Monodelphis domestica
456600 Pan troglodytes
100602436 Nomascus leucogenys
249 Homo sapiens
11647 Mus musculus
25586 Rattus norvegicus
280994 Bos taurus
100170147 Sus scrofa
727689 Felis catus
396317 Gallus gallus
101123195 Ovis aries
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