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The protein encoded by ABCF2 is a member of the superfamily of ATP-binding cassette (ABC) transporters.
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The NRF2 (显示 GABPA 抗体)-overexpressing cell line, containing high levels of ABCF2, was more resistant to cisplatin-induced apoptosis compared to its control ovarian cancer cell line; whereas the NRF2 (显示 GABPA 抗体) knockdown cell line with low levels of ABCF2, was more sensitive to cisplatin treatment than its control cell line.
Overexpression of ABCF2 suppressed RVD.
ABCF2 may have a role in progression of clear cell ovarian adenocarcinomas
Data suggest that ABCF2 protein may be a candidate marker for clear cell adenocarcinomas of the ovary and the uterine corpus and may be important for the pathogenesis of these diseases.
Among cervical cancer cases, 149 (55.8%) expressed ABCF2. The overall survival was longer in ABCF2-negative than ABCF2-positive cases
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants.
ABC transporter, class F family member (abcf-2)
, ATP-binding cassette sub-family F member 2
, ATP-binding cassette, sub-family F (GCN20), member 2
, ATP-binding cassette, sub-family F, member 2
, ATP-binding cassette sub-family F member 2-like
, ABC-type transport protein
, iron-inhibited ABC transporter 2
, developmentally regulated repeat element-containing transcript 3