anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) 抗体

The protein encoded by ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters.

列出全部抗体 基因 基因ID UniProt
 ABCC6 ABCC6 368 O95255
小鼠 ABCC6 ABCC6 27421 Q9R1S7
大鼠 ABCC6 ABCC6 81642 O88269
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antibodies-online.cn销售最多的anti-ABCC6 抗体

Showing 10 out of 32 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged ABCC6 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8至11个工作日
大鼠 非结合性 IHC (fro), IF, WB   1 mL Log in to see 6至8个工作日
大鼠 非结合性 IHC (fro), FACS, IF, IHC (p), WB   1 mL Log in to see 6至8个工作日
小鼠 非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Used in DAB staining on fromalin fixed paraffin- embedded kidney tissue 100 μg Log in to see 13至16个工作日
小鼠 非结合性 ELISA, WB Detection limit for recombinant GST tagged ABCC6 is approximately 0.03ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 11至12个工作日
大鼠 非结合性 ICC, IHC, IHC (fro), WB   1000 μL Log in to see 7至9个工作日
大鼠 非结合性 ICC, IHC, WB   1000 μL Log in to see 7至9个工作日
小鼠 非结合性 ELISA, WB   100 μg Log in to see 7至9个工作日
小鼠 非结合性 ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Log in to see 11至12个工作日
小鼠 非结合性 WB Western Blot analysis of ABCC6 expression in transfected 293T cell line by ABCC6 MaxPab polyclonal antibody.<br><br>Lane 1: ABCC6 transfected lysate(10.89 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Log in to see 11至12个工作日

引用最多的anti-ABCC6 抗体

  1. Human Monoclonal ABCC6 Primary Antibody for ELISA, WB - ABIN559916 : Pinckard, Sheehan, Arthur, Schreiber: Constitutive shedding of both p55 and p75 murine TNF receptors in vivo. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 2 Pubmed References


Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. ABCC6 overexpression may also contribute to nilotinib and dasatinib resistance in vitro. With nilotinib and dasatinib now front line therapy options in the treatment of CML (显示 BCR 抗体), concomitant administration of ABCC6 inhibitors may present an attractive option to enhance TKI efficacy

  2. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6, ABCB1 (显示 ABCB1 抗体) and CYP2C8 (显示 CYP2C8 抗体) associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

  3. ABCC6 knockdown HepG2 cells show: 1) intracellular reductive stress; 2) cell cycle arrest in G1 phase; 3) upregulation of p21Cip p53 (显示 TP53 抗体) independent; and 4) downregulation of lamin A/C (显示 LMNA 抗体). the absence of ABCC6 profoundly changes the HepG2 phenotype, suggesting that Pseudoxanthoma elasticum syndrome is a complex metabolic disease that is not exclusively related to the absence of pyrophosphate in the bloodstream.

  4. ABCC6 deficiency can be rescued by 4-phenylbutyrate therapy in a mouse model expressing human variants

  5. Biochemical and cell biological analyses demonstrate these mutations influence multiple steps in the biosynthetic pathway, minimally altering local domain structure but adversely impacting ABCC6 assembly and trafficking. The differential impacts on local and global protein structure are consistent with hierarchical folding and assembly of ABCC6.

  6. The results suggest that a transmembrane domain is not required for transport function and that a cytosolic loop maintains ABCC6 in a targeting-competent state for the basolateral membrane and might be involved in regulating the nucleotide binding domains.

  7. The results of this study showed that mtDNA(atp6 (显示 MT-ATP6 抗体)) variants were actively involved in schizophrenia in some families with maternal inheritance of this

  8. Pseudoxanthoma elasticum is due to mutation of the ABCC6 gene on chromosome 16.

  9. Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6

  10. A direct relationship between reduced ABCC6 levels and the expression of pro-mineralization genes in hepatocytes.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. abrogated ABCC6 function does cause alterations in the metabolic profile of the liver in accordance with PXE being a metabolic disease originating from liver disturbance

  2. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 gene.

  3. In a mouse model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.

  4. In the Abcc6(-/-) genotype, dermal fibroblasts actively contribute to changes that promote matrix calcification; these cells can be further modulated with time by the calcified environment, contributing to the age-dependent progression.

  5. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries

  6. Magnesium oxide reduces carotid intima media thickness in Abcc6-/- mouse model for pseudoxanthoma elasticum.

  7. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1 (显示 ENPP1 抗体)(asj (显示 ARSJ 抗体)) mice.

  8. Report lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction in aged Abcc6(-/-) mouse model of pseudoxanthoma elasticum.

  9. the development of cardiac hypertrophy in the 24-month-old Abcc6(-/-) mice suggests that old pseudoxanthoma elasticum patients might be prone to developing late cardiopathy.

  10. ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation.

ABCC6 抗原简介


The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with ABCC6

  • ATP binding cassette subfamily C member 6 (ABCC6) 抗体
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (Abcc6) 抗体
  • ATP binding cassette subfamily C member 6 (Abcc6) 抗体
  • ABC34 抗体
  • Abcc1b 抗体
  • ARA 抗体
  • DCC 抗体
  • dyscalc 抗体
  • Dyscalc1 抗体
  • EST349056 抗体
  • GACI2 抗体
  • MLP1 抗体
  • MOAT-E 抗体
  • MOATE 抗体
  • Mrp6 抗体
  • PXE 抗体
  • PXE1 抗体
  • URG7 抗体

Protein level used designations for ABCC6

ATP-binding cassette sub-family C member 6 , anthracycline resistance-associated protein , multi-specific organic anion transporter E , multidrug resistance-associated protein 6 , ATP-binding cassette, sub-family C, member 6 , multidrug resistance-associated protein-6 , ATP-binding cassette, sub-family C (CFTR/MRP), member 6 , MLP-1 , MRP-like protein 1 , liver multidrug resistance-associated protein 6

368 Homo sapiens
27421 Mus musculus
81642 Rattus norvegicus