ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) ELISA试剂盒

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上,我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 抗体 (207)ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 蛋白 (7)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
ABCB1 5243 P08183
ABCB1 170913  
ABCB1 18669 P06795
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Showing 9 out of 20 products:

产品编号 适用 灵敏度 范围 图像 规格 交付 价格 详细
大鼠 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests 15至18个工作日
0.076 ng/mL 0.156-10 ng/mL   96 Tests 6至8个工作日
  96 Tests 6至8个工作日
小鸡 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11至18个工作日
豚鼠 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11至18个工作日
0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11至18个工作日
Pig 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests 11至18个工作日
75 pg/mL 125 pg/mL - 8000 pg/mL   96 Tests 11至18个工作日
绵羊 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11至18个工作日

适于 ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 相互作用对的更多 ELISA 试剂盒

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. These results suggest that Pgp and endogenous TNF-alpha positively regulate cancer cell malignancy and contribute to changes in normal cell behavior through membrane microparticles.

  2. An independent effect was not evident for MDR1 C3435T polymorphism.

  3. ATP binding cassette subfamily B member 1 (ABCB1) 2677G>T is suggested to be an important determinant of warfarin dosage.

  4. Results found that MDR1 expression level is downregulated in FK866-resistant HCT116 colorectal cancer cell line and provide evidence that ABCB1 plays a key role in CRC drug resistance to NAMPT inhibitor FK866.

  5. In both extravillous trophoblast and cytotrophoblast explant differentiation experiments, silencing of ABCB1 leads to induction of the fusion markers human hCG, ERVW-1 and GJA1 and terminal differentiation of both trophoblast subtypes.

  6. Together with previous data, these findings lead to a general model of substrate and inhibitor coupling to P-glycoprotein.

  7. We performed the first population PK-PD study assessing the influence of ABCB1 gene polymorphisms and the expression of this gene on the thromboprophylactic therapy with rivaroxaban in patients undergoing knee or hip replacement surgery. We observed a decrease in ABCB1 expression after the orthopedic surgery and demonstrated a positive correlation between the ABCB1 gene expression and the rivaroxaban CL/F.

  8. The donor and recipient CYP3A5*3 polymorphism influences tacrolimus pharmacokinetics in the first month post-transplantation, whereas the association with recipient ABCB1 3435 C > T is inconclusive.

  9. high expression of MDR1 can affect the efflux ability to Methotrexate (MTX) by up-regulating the expression of P-gp, thus enhancing the drug resistance to MTX in rheumatoid arthritis fibroblast-like synoviocytes

  10. Genotypes of the rs1202184 locus of the MDR1 gene are associated with refractory epilepsy in children, for which the AA genotype plays a dominant role.

  11. Results indicate that elevated ABCB1 expression induced by C-terminal truncation of HBx was responsible for doxorubicin resistance in HCC.

  12. The results reveal the potential regulatory mechanism of FTH1P3 on breast cancer paclitaxel resistance through miR-206/ABCB1 axis.

  13. Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells.

  14. High MDR1 expression is associated with acute lymphoblastic leukemia.

  15. The study demonstrated that the simultaneous presence of TMDR1, A CYP2D6*4 and A NAT2*7 alleles robustly increased the risk of developing ulcerative colitis by 3.49-fold. The current study suggests that CYP2D6*4 and MDR1 3435 C/T gene polymorphisms may be risk factors for UC susceptibility.

  16. HIF1A-induced MDR1 and MRP4 promote Th17 responses in Crohn's disease.

  17. In conclusion, we provide evidence that P-gp may be involved in an AhR-dependent detoxification process induced in response to the uremic toxin IS.

  18. sofosbuvir GS-331007 metabolite plasma levels were affected by variants in the ABCB1 and HNFalpha genes

  19. The contribution of polymorphisms in ABCB1 to drug pharmacokinetics.

  20. FENDRR attenuates NSCLC cell stemness through inhibiting the HuR/MDR1 axis

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) interaction partners

  1. ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.

  2. esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models.

  3. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

  4. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

  5. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

  6. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

  7. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp.

  8. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.

  9. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

  10. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  11. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  12. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  13. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

  14. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

  15. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  16. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

  17. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

  18. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application

  19. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

  20. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) 抗原简介

Antigen Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1) 抗体
  • ATP binding cassette subfamily B member 1A (Abcb1a) 抗体
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L) 抗体
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b) 抗体
  • ATP binding cassette subfamily B member 1 (Abcb1) 抗体
  • ABC20 抗体
  • ABCB1 抗体
  • CD243 抗体
  • CLCS 抗体
  • GP170 抗体
  • mdr 抗体
  • Mdr1 抗体
  • Mdr1a 抗体
  • Mdr1b 抗体
  • p-gp 抗体
  • PGP1 抗体
  • Pgy-1 抗体
  • Pgy1 抗体
  • xemdr 抗体

Protein level used designations for ABCB1

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , bovine P-glycoprotein , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B

5243 Homo sapiens
170913 Rattus norvegicus
281585 Bos taurus
403879 Canis lupus familiaris
397812 Xenopus laevis
463516 Pan troglodytes
18669 Mus musculus
100682536 Cricetulus griseus
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