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The membrane-associated protein encoded by ABCA5 is a member of the superfamily of ATP-binding cassette (ABC) transporters.
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Human Polyclonal ABCA5 Primary Antibody for ELISA - ABIN449691
Petry, Kotthaus, Hirsch-Ernst: Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant. in Biochemical and biophysical research communications 2002
This report represents the first extensive expression and functional study of ABCA5 in the human brain and our data suggest a plausible function of ABCA5 in the brain as a cholesterol transporter associated with Abeta (显示 APP 抗体) generation
our findings support ABCA5 as a gene underlying the congenital generalized hypertrichosis terminalis phenotype and suggest a novel, previously unrecognized role for this gene in regulating hair growth.
The expression of ABCA5 was significantly elevated in parkinson disease brains compared to age- and gender-matched control brains.
Identification of CBX3 (显示 CBX3 抗体) and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.
The ABCB5 (显示 ABCB5 抗体) gene may be related to the properties of chemoresistance and aggressiveness of melanoma
Cloning of ABCA5 and detection of a splice variant.
ABCA5 may have a role in prostatic intraepithelial neoplasia
There is a correlation of induction of ABCA5 and mRNA with differentiation of colonic neoplasms.
ABCA5 influences macrophage cholesterol efflux, and selective disruption of ABCA5 in macrophages leads to increased atherosclerotic lesion development in female LDLr (显示 LDLR 抗体)(-/-) mice.
ABCA5 is a protein related to a lysosomal disease and plays important roles, especially in cardiomyocytes and follicular cells
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants\; however, not all variants have been fully described.
ATP-binding cassette, sub-family A , member 5
, ATP-binding cassette, sub-family A (ABC1), member 5
, ATP-binding cassette sub-family A member 5
, ATP-binding cassette sub-family A member 5-like
, ATP-binding cassette A5
, ATP-binding cassette transporter sub-family A member 5