ABL1 产品
(C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
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The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9\;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008].
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Featured ABL1 Categories
ABL1 抗体
High quality antibodies with extensive validation data.
ABL1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ABL1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ABL1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN3020872
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), DB
Validations
- (1)
- (4)
Cat. No.
ABIN6241067
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (1)
- (4)
Cat. No.
ABIN6256686
Quantity
100 μL
Datasheet
Datasheet
Recommended ABL1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN6730567
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975039
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380761
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended ABL1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5570741
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569840
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569841
Quantity
5 μg
Datasheet
Datasheet
Latest Publications for our ABL1 Products
: "Defining the target and the effect of imatinib on the filarial c-Abl homologue." in: PLoS neglected tropical diseases, Vol. 11, Issue 7, pp. e0005690, (2017) (PubMed).: "A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy." in: The Analyst, Vol. 140, Issue 4, pp. 1207-14, (2015) (PubMed).
: "Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease." in: Redox biology, Vol. 2, pp. 82-90, (2015) (PubMed).
: "Altered expression of c-Abl in patients with epilepsy and in a rat model." in: Synapse (New York, N.Y.), Vol. 68, Issue 7, pp. 306-16, (2014) (PubMed).
: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." in: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).
: "Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway." in: Scientific reports, Vol. 4, pp. 6527, (2014) (PubMed).
: "Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons." in: The Journal of biological chemistry, Vol. 288, Issue 33, pp. 23725-39, (2013) (PubMed).
: "Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors." in: PLoS ONE, Vol. 7, Issue 10, pp. e45964, (2012) (PubMed).
: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).
: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).
Synonyms and alternative names related to ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), c-abl oncogene 1, non-receptor tyrosine kinase (Abl1), ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), Tyrosine-protein kinase abl-1 (abl-1), c-abl oncogene 1, non-receptor tyrosine kinase (abl1), ABL, Abl, AI325092, bcr/abl, c-ABL, c-Abl, E430008G22Rik, JTK7, p150, v-ablProtein level used designations for ABL1
- Abelson tyrosine-protein kinase 1
- bcr/c-abl oncogene protein
- c-abl oncogene 1, receptor tyrosine kinase
- proto-oncogene c-Abl
- proto-oncogene tyrosine-protein kinase ABL1
- tyrosine-protein kinase ABL1
- v-abl Abelson murine leukemia viral oncogene homolog 1
- Abelson murine leukemia oncogene
- abelson murine leukemia viral oncogene homolog 1
- p150
- v-abl Abelson murine leukemia oncogene 1
- Abelson murine leukemia viral (v-abl) oncogene homolog 1
- v-abl Abelson murine leukemia viral oncogene 1
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