ABCB1 蛋白
(ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008].
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ABCB1
宿主: 人
宿主: 小麦胚
Recombinant
ELISA, WB, AP, AA
1 image
1 reference
custom-made
ABCB1
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Latest Publications for our ABCB1 蛋白
: "Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria." in: Pharmaceutical research, Vol. 25, Issue 6, pp. 1469-83, (2008) (PubMed).
Aliases for ABCB1 蛋白
ATP binding cassette subfamily B member 1 (ABCB1) 蛋白ATP binding cassette subfamily B member 1A (Abcb1a) 蛋白
ATP binding cassette subfamily B member 1 L homeolog (abcb1.L) 蛋白
ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b) 蛋白
ATP binding cassette subfamily B member 1 (Abcb1) 蛋白
ABC20 蛋白
Abcb1 蛋白
ABCB1 蛋白
CD243 蛋白
CLCS 蛋白
GP170 蛋白
mdr 蛋白
MDR1 蛋白
Mdr1 蛋白
Mdr1a 蛋白
Mdr1b 蛋白
P-GP 蛋白
p-gp 蛋白
PGP1 蛋白
Pgy-1 蛋白
PGY1 蛋白
Pgy1 蛋白
xemdr 蛋白
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