(ATP-Binding Cassette, Sub-Family A (ABC1), Member 2 (ABCA2))
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Huang, Zhang, Jiang, Zhang, Xiang, Ren: "FoxM1 Induced Paclitaxel Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter." in: Molecular therapy oncolytics, Vol. 14, pp. 196-212, (2019) (PubMed).
Macé, Cousin, Ricard, Génin, Spanakis, Lafargue-Soubigou, Génin, Fournel, Roche, Haussy, Massey, Soubigou, Bréfort, Benoit, Brice, Campion, Hollis, Pradier, Benavides, Deleuze: "ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease." in: Neurobiology of disease, Vol. 18, Issue 1, pp. 119-25, (2005) (PubMed).
Aliases for ABCA2 抗体
ATP binding cassette subfamily A member 2 (ABCA2) 抗体 ATP-binding cassette, sub-family A (ABC1), member 2 (Abca2) 抗体 ATP binding cassette subfamily A member 2 (Abca2) 抗体 ATP binding cassette subfamily A member 2 (abca2) 抗体 ATP-binding cassette, sub-family A (ABC1), member 2 (abca2) 抗体 ABC2 抗体 Abc2 抗体 AI413825 抗体 D2H0S1474E 抗体 mKIAA1062 抗体 si:dkey-266h7.1 抗体