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Mouse (Murine) FTH1 Protein expressed in Escherichia coli (E. coli) - ABIN1079501
Inokura, Fujiwara, Saito, Iino, Hatta, Okitsu, Fukuhara, Onishi, Ishizawa, Shimoda, Harigae: Impact of TET2 deficiency on iron metabolism in erythroblasts. in Experimental hematology 2017
Fe mediated decrease of lateral root length and density is enhanced in fer1-3-4 triple mutant plants.
phosphate starvation response of AtFer1 is not linked to the iron status of plants and is specifically initiated by phosphate deficiency
Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1 (显示 PARP3 蛋白), bHLH39, and FER1, oscillated in light/dark (LD) cycles or warm/cold environmental cycles.
Data show that a leaf glutathione concentration threshold between 10 and 50 nmol GSHg(-1) FW is required for full induction of AtFer1 gene expression in response to iron.
new regulatory pathway involved in plant response to oxidative stress was revealed using the iron-induced Arabidopsis ferritin (显示 FTL 蛋白) AtFER1 as a model
Ferritin (显示 FTL 蛋白) accumulation during infection of Arabidopsis by E. chrysanthemi is a basal defense mechanism which is mainly activated by bacterial siderophores.
The X-ray crystal structure of the apoferritin-SDS (显示 SDS 蛋白) complex was determined at a resolution of 1.9 A and revealed that the SDS (显示 SDS 蛋白) binds in an internal cavity that has previously been shown to recognize various general anesthetics. [apoferritin]
Transmission electron microscopy shows a clear selectivity of alkylated ferritin (显示 FTL 蛋白) adsorption onto the PCL (显示 PKD2L1 蛋白) phase while wild ferritin (显示 FTL 蛋白) predominantly adsorbs onto the PDTD phase.
the absence of Mitochondrial ferritin (显示 FTMT 蛋白), which is highly expressed in the heart, increases the sensitivity of mitochondria to cardiac injury via oxidative stress.
As previously reported, homozygous loss of the Fth allele on a wild-type Ftl (显示 FTL 蛋白) background was embryonic lethal. expression of the H subunit can rescue the loss of the L subunit and that H ferritin homopolymers have the capacity to sequester iron in vivo
provide a new mechanism for selective autophagy of ferritin (显示 FTL 蛋白) and reveal a previously unappreciated role for autophagy and NCOA4 (显示 NCOA4 蛋白) in the control of iron homeostasis in vivo
Our data show that ferritin H (显示 FTMT 蛋白) is required for B and T cell survival by actively reducing the labile iron pool.
Ferritin H (显示 FTMT 蛋白) deficiency in most cells of the forebrain including cells of the choroid plexus caused accumulation of cerebrospinal fluid in the lateral ventricles and the subarachnoid space
Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.
3-Hydroxybutyrate dehydrogenase (显示 BDH1 蛋白)-2 and ferritin-H (显示 FTMT 蛋白) synergistically regulate intracellular iron.
Fth plays a critical protective role during acute kidney injury.
FtH provides metabolic adaptation to tissue Fe overload, conferring tolerance to malaria
The delivery of iron to oligodendrocytes via H-ferritin is a biologically relevant delivery system, given that ferritin (显示 FTL 蛋白)--not transferrin (显示 Tf 蛋白)--receptors can be demonstrated on oligodendrocytes in vivo.
Low levels of FTH-positive tumor cells and microglia/macrophages were associated with poor survival in anaplastic astrocytomas, while high amounts of FTL (显示 FTL 蛋白)-positive microglia/macrophages had a negative prognostic value
fumarate increases ferritin (显示 FTL 蛋白) gene transcription by activating the NRF2 (显示 GABPA 蛋白) (nuclear factor [erythroid-derived 2]-like 2) transcription factor.
there is no significant relationship between serum ferritin (显示 FTL 蛋白) concentrations and depressive symptoms among Chinese adults.
Data suggest that, in homopolymeric H-subunit ferritin (显示 FTL 蛋白) (HuHF), iron oxidation proceeds with a 2:1 Fe(II):O(2) stoichiometry at iron level of 2 Fe(II) atoms/H-subunit with generation of H2O2; L-subunit-rich heteropolymeric ferritin (显示 FTL 蛋白) also facilitates iron oxidation at the ferroxidase (显示 CP 蛋白) center and additionally promotes oxidation at the mineral surface once iron-binding capacity has been exceeded.
Elevated serum ferritin (显示 FTL 蛋白) levels are associated with hematologic malignancies.
Ferritin light chain (显示 FTL 蛋白) and ferritin heavy chain are required for the neural differentiation of bone marrow-derived mesenchymal stem cells under extremely low-frequency electromagnetic field.
Human FTH1 is a general pro-survival sequence.
H-ferritin tissue expression and the number of CD68 (显示 CD68 蛋白)+/H-ferritin+ cells were increased in the lymph nodes of adult-onset Still's disease patients, and these results correlated significantly with disease severity
Studies indicate that the the best characterized cytosolic ferritins in mammals are encoded by two genes, FTH and FTL (显示 FTL 蛋白), with four exons and similar structures.
high cytoplasmic FTH1 was associated with favorable prognosis whereas nuclear FTH1 staining was associated with adverse prognosis in triple negative breast cancer
ferritin heavy chain up-regulation may be mediated by activation of NF-kappaB (显示 NFKB1 蛋白) and that in turn this may be related to the resistance of bovine papillomavirus type-2 (BPV-2) infected urothelial cells to apoptosis.
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
ferritin heavy chain
, ferritin, heavy polypeptide 1
, ferritin H subunit B
, ferritin heavy chain 1
, ferritin heavy chain B
, ferritin, heavy polypeptide 1 b
, ferritin H chain
, ferritin H subunit
, Ferritin H subunit
, cell proliferation-inducing gene 15 protein
, placenta immunoregulatory factor
, proliferation-inducing protein 15
, ferritin heavy-chain
, Ferritin subunit H
, ferritin heavy polypeptide 1
, ferritin, heavy polypeptide-like 17 like 5