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Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (显示 IFNB1 ELISA试剂盒) (TRIF (显示 TRIM69 ELISA试剂盒)) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF (显示 TRIM69 ELISA试剂盒)/RIPK1 (显示 RIPK1 ELISA试剂盒)/caspase-8 (显示 CASP8 ELISA试剂盒) occurs in fibrillary platforms.
Therefore, Seneca Valley virus suppressed antiviral interferon (显示 IFNA ELISA试剂盒) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (显示 MAVS ELISA试剂盒), TRIF (显示 TRIM69 ELISA试剂盒), and TANK by its 3C protease.
TRIF (显示 TRIM69 ELISA试剂盒) gene may contribute to susceptibility of T2DM.
The NF-kappaB (显示 NFKB1 ELISA试剂盒) activated by dsRNA appears not to be the canonical p65 (显示 GORASP1 ELISA试剂盒)/p50 (显示 CD40 ELISA试剂盒) heterodimers.
We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (显示 FOXE1 ELISA试剂盒)/HEMGN (显示 HEMGN ELISA试剂盒), SERPINA5 (显示 SERPINA5 ELISA试剂盒) (rs2069974), FTO (显示 FTO ELISA试剂盒) (rs8047395), EVPL (显示 EVPL ELISA试剂盒) (rs2071194), TICAM1 (rs8120) and SCARB1 (显示 SCARB1 ELISA试剂盒) (rs11057820) genes. We found associations with SNPs in FOXE1 (显示 FOXE1 ELISA试剂盒), SERPINA5 (显示 SERPINA5 ELISA试剂盒), FTO (显示 FTO ELISA试剂盒), TICAM1 and HSPA6 (显示 HSPA6 ELISA试剂盒) and and follicular thyroid cancer
IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF (显示 TRIM69 ELISA试剂盒).
TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT (显示 CHPT1 ELISA试剂盒)-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line
involved in signaling that moderates the expression of heme oxygenase1 and il-8 (显示 IL8 ELISA试剂盒) after keratinocytes exposure to dinitrochlorobenzene
Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (显示 DEFB103A ELISA试剂盒) suppresses the polyI:C-induced TLR3 (显示 TLR3 ELISA试剂盒) response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (显示 IFIH1 ELISA试剂盒)) and MAVS (IPS1/CARDIF (显示 MAVS ELISA试剂盒)).
signaling through TRIF (显示 TRIM69 ELISA试剂盒) is important for the inflammatory response of AngII-induced abdominal aortic aneurysm formation
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒)-regulated apoptosis and the p53 (显示 TP53 ELISA试剂盒)/PCNA (显示 PCNA ELISA试剂盒)- and ATM (显示 ATM ELISA试剂盒)/ATR (显示 ATR ELISA试剂盒)-Chk1 (显示 CHEK1 ELISA试剂盒)/2-controlled DNA-damage response pathways.
Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule (显示 NCAM1 ELISA试剂盒) expression are regulated by both the MyD88 (显示 MYD88 ELISA试剂盒)- and TRIF (显示 RNF138 ELISA试剂盒)-dependent pathways.
TRIF (显示 RNF138 ELISA试剂盒) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (显示 FOSL1 ELISA试剂盒) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (显示 TRAF3 ELISA试剂盒)), TIR domain-containing adapter inducing IFN-beta (显示 IFNB1 ELISA试剂盒) (TRIF (显示 RNF138 ELISA试剂盒)), and Tank-binding kinase 1 (TBK1 (显示 TBK1 ELISA试剂盒)) via impairing K63-linked polyubiquitination of TRAF3 (显示 TRAF3 ELISA试剂盒) and TRIF (显示 RNF138 ELISA试剂盒).
These results suggested the importance of TRIF (显示 RNF138 ELISA试剂盒) in TLR2 (显示 TLR2 ELISA试剂盒) mediated foam cell formation via inflammatory mediators, including MCP-1 (显示 CPT1B ELISA试剂盒).
DENV replication and IFNalpha/beta, TNF-alpha (显示 TNF ELISA试剂盒), IL-12 (显示 IL12A ELISA试剂盒) and IL-18 (显示 IL18 ELISA试剂盒) in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF (显示 RNF138 ELISA试剂盒), MYD88 (显示 MYD88 ELISA试剂盒) or NF-kB inhibition
The authors demonstrate that, in addition to MyD88 (显示 MYD88 ELISA试剂盒), Yersinia pseudotuberculosis inhibits TRIF (显示 RNF138 ELISA试剂盒) signaling through the type III secretion system effector YopJ.
Results show that toll (显示 TLR4 ELISA试剂盒)/IL-1 (显示 IL1A ELISA试剂盒) domain-containing adaptor inducing IFN-beta (显示 IFNB1 ELISA试剂盒) (TRIF (显示 RNF138 ELISA试剂盒)) is essential for Toll (显示 TLR4 ELISA试剂盒)-like receptors TLR3 (显示 TLR3 ELISA试剂盒)- and TLR4 (显示 TLR4 ELISA试剂盒)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
Data show that annexin A2 (AnxA2 (显示 ANXA2 ELISA试剂盒)) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4 (显示 TLR4 ELISA试剂盒))-initiated TRAM protein (显示 TRAM2 ELISA试剂盒)-TRIF (显示 RNF138 ELISA试剂盒) protein pathway occurring on endosomes.
ProTalpha preconditioning-induced prevention of retinal ischemic damage is mediated by selective activation of the TIR-domain-containing adapter-inducing interferon-beta (显示 IFNB1 ELISA试剂盒) interferon regulatory factor 3 (显示 IRF3 ELISA试剂盒) pathway downstream of toll-like receptor 4 (显示 TLR4 ELISA试剂盒) in microglia
Inhibition of the Toll (显示 TLR4 ELISA试剂盒)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (显示 IFNB1 ELISA试剂盒) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.
3D-models of rohu TLR3 (显示 TLR3 ELISA试剂盒)-TIR and zebrafish TRIF
The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (显示 NFKB1 ELISA试剂盒) and zebrafish type I IFN was described.
study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (显示 NFKB1 ELISA试剂盒) response promoter
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
TIR domain-containing adapter molecule 1
, TIR domain containing adaptor inducing interferon-beta
, toll-interleukin I receptor domain containing adaptor molecule 1
, toll-like receptor adaptor molecule 1
, TIR domain-containing adapter molecule 1-like
, TIR domain-containing adapter protein inducing IFN-beta
, proline-rich, vinculin and TIR domain-containing protein B
, putative NF-kappa-B-activating protein 502H
, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
, TIR domain-containing adaptor inducing interferon-beta
, toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
, TIR-domain containing adaptor inducing IFN-beta