anti-Dystrobrevin Binding Protein 1 (DTNBP1) 抗体产品概述

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anti-Dystrobrevin Binding Protein 1 抗体 (DTNBP1)
在www.antibodies-online.cn可供118 Dystrobrevin Binding Protein 1 (DTNBP1) 抗体的16不同的供货商。 再加上,我们可以发Dystrobrevin Binding Protein 1 蛋白 (17)Dystrobrevin Binding Protein 1 试剂盒 (8)和数多这个蛋白质的别的产品。 总共150 Dystrobrevin Binding Protein 1产品已列进来了。
别名:
5430437B18Rik, AW048963, Bloc1s8, CG6856, DBND, Ddysb, Dmel\\CG6856, DTNBP1, dysbindin, HPS7, MGC83903, MGC85477, My031, sdy, zgc:56462

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  1. Human Polyclonal DTNBP1 Primary Antibody for EIA, WB - ABIN952010 : Haukvik, Saetre, McNeil, Bjerkan, Andreassen, Werge, Jönsson, Agartz: An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes. in Progress in neuro-psychopharmacology & biological psychiatry 2010 (PubMed)
    Show all 3 references for 952010

  2. Human Polyclonal DTNBP1 Primary Antibody for EIA, IHC (p) - ABIN357845 : Benson, Newey, Martin-Rendon, Hawkes, Blake: Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. in The Journal of biological chemistry 2001 (PubMed)
    Show all 3 references for 357845

  3. Human Polyclonal DTNBP1 Primary Antibody for IHC, IHC (p) - ABIN4306530 : Gokhale, Mullin, Zlatic, Easley, Merritt, Raj, Larimore, Gordon, Peden, Sanyal, Faundez: The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 (PubMed)
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更多抗Dystrobrevin Binding Protein 1的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Dystrobrevin Binding Protein 1 (DTNBP1) interaction partners

  1. Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess (显示 RCC1 抗体) is a neurotoxin and whose depletion constitutes a micronutrient deficiency.

  2. Loss-of-function alleles of dysbindin or Blos1 (显示 BLOC1S1 抗体) impaired neurotransmitter release and synaptic function and plasticity.

  3. optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal

  4. study found that dysbindin (CG6856) is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx

Human Dystrobrevin Binding Protein 1 (DTNBP1) interaction partners

  1. Data suggest that, in cardiomyocytes, TRIM32 attenuates activation of SRF signaling and hypertrophy due to dysbindin; TRIM24 promotes these effects. TRIM32 promotes dysbindin degradation; TRIM24 protects dysbindin from degradation. (TRIM = tripartite motif-containing protein; SRF = serum response factor)

  2. Authors report the examination of DNA methylation status of DTNBP1 promoter region, one of the most credible candidate genes affected in SCZ.

  3. DTNBP1 is likely to play a role in development of auditory related, visual and olfactory hallucinations

  4. dysbindin-1A protein levels are highly regulated in the nucleus and that dysbindin-1A regulates transcription factor NF-kappa B (显示 NFKB1 抗体) activity to promote the expression of MMP-9 (显示 MMP9 抗体) and TNF-alpha (显示 TNF 抗体)

  5. Study demonstrated that dysbindin-1B, rather than dysbindin-1A and dysbindin-1C, has the ability to aggregate

  6. The present findings intransgenic mice expressing human DTNBP1 support the role of dysbindin-1 in psychiatric disorders.

  7. Findings add further evidence suggesting an association between dysbindin gene variability and cognitive abnormalities in schizophrenia.

  8. dysbindin-1 formed a protein complex with HDAC3 (显示 HDAC3 抗体) in human neuroblastoma (显示 ARHGEF16 抗体) cells

  9. DISC1 forms a complex with dysbindin and increases its sta (显示 DISC1 抗体)bility in association with a reduction in ubiquitylation.

  10. In homozygotes and heterozygotes of risk allele (CC) of DTNBP1, there was a trend to volumetric reductions in brain regions, regardless of schizophrenia diagnosis.

Mouse (Murine) Dystrobrevin Binding Protein 1 (DTNBP1) interaction partners

  1. loss of DTNBP1 in pyramidal neurons diminished activity-dependent secretion of brain-derived neurotrophic factor (BDNF (显示 BDNF 抗体)).

  2. Dysbindin-1 modulates thus D2 and D3 receptor (显示 DRD3 抗体) signaling, supporting a link to schizophrenia

  3. Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess (显示 RCC1 抗体) is a neurotoxin and whose depletion constitutes a micronutrient deficiency.

  4. Results suggest that Dtnbp1 deficiency may lead to increased vulnerability to schizophrenia under environmental conditions where circadian rhythms are altered

  5. Snapin-dysbindin interaction regulates synaptic vesicle positional priming through BLOC-1/AP-3-dependent sorting.

  6. Dysbindin has three isoforms associating with different complexes in the P2 fraction of mouse brain.

  7. Dysbindin-1C deficiency causes impaired autophagy, which is likely implicated in the pathogenesis of schizophrenia.

  8. The neurite outgrowth defect induced by knockdown of DISC1 (显示 DISC1 抗体) was partially reversed by coexpression of dysbindin.

  9. dysbindin-1C, rather than dysbindin-1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner

  10. loss of function mutations in the genes encoding dysbindin and its interacting BLOC-1 (显示 PLDN 抗体) subunits

Dystrobrevin Binding Protein 1 (DTNBP1) 抗原简介

Antigen Summary

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with Dystrobrevin Binding Protein 1 (DTNBP1)

  • dystrobrevin binding protein 1 (DTNBP1) 抗体
  • dysbindin (dysb) 抗体
  • Dysbindin (dtbp1) 抗体
  • dystrobrevin binding protein 1a (dtnbp1a) 抗体
  • dystrobrevin binding protein 1 (dtnbp1) 抗体
  • dystrobrevin binding protein 1 (Dtnbp1) 抗体
  • 5430437B18Rik 抗体
  • AW048963 抗体
  • Bloc1s8 抗体
  • CG6856 抗体
  • DBND 抗体
  • Ddysb 抗体
  • Dmel\\CG6856 抗体
  • DTNBP1 抗体
  • dysbindin 抗体
  • HPS7 抗体
  • MGC83903 抗体
  • MGC85477 抗体
  • My031 抗体
  • sdy 抗体
  • zgc:56462 抗体

Protein level used designations for DTNBP1

dysbindin , CG6856-PA , CG6856-PB , dysb-PA , dysb-PB , Dysbindin , BLOC-1 subunit 8-A , biogenesis of lysosome-related organelles complex 1 subunit 8-A , dysbindin-A , dystrobrevin binding protein 1 , dystrobrevin-binding protein 1-A , BLOC-1 subunit 8 , Hermansky-Pudlak syndrome 7 protein , biogenesis of lysosomal organelles complex-1, subunit 8 , biogenesis of lysosome-related organelles complex 1 subunit 8 , dysbindin-1 , HPS7 protein homolog , dystrobrevin-binding protein 1 , hermansky-Pudlak syndrome 7 protein homolog , sandy , distrobrevin binding protein 1

GENE ID SPECIES
100145862 Ovis aries
40052 Drosophila melanogaster
100195576 Salmo salar
394109 Danio rerio
446421 Xenopus laevis
447615 Xenopus laevis
747324 Pan troglodytes
100216117 Xenopus (Silurana) tropicalis
84062 Homo sapiens
94245 Mus musculus
420840 Gallus gallus
100049697 Sus scrofa
506612 Bos taurus
641528 Rattus norvegicus
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