anti-TECTA (TECTA) 抗体产品概述

Full name:
anti-Tectorin alpha 抗体 (TECTA)
在www.antibodies-online.cn可供8 Tectorin alpha (TECTA) 抗体的7不同的供货商。 再加上,我们可以发和数多这个蛋白质的别的产品。 总共9 TECTA产品已列进来了。
别名:
DFNA8, DFNA12, DFNB21, Tctna
列出全部抗体 基因 基因ID UniProt
TECTA 7007 O75443
TECTA 21683 O08523
TECTA 300653  

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Human Tectorin alpha (TECTA) interaction partners

  1. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4 (显示 EYA4 抗体)), DFNA8/12 (TECTA), DFNA13 (COL11A2 (显示 COL11A2 抗体)), DFNA44 (CCDC50 (显示 CCDC50 抗体)), have been reported to date. [review]

  2. A novel homozygous variant (c.734G > A) was found in exon 5 of the TECTA gene in one family leading to a nonsense mutation causing autosomal recessive nonsyndromic hearing loss.

  3. To our knowledge, this is the first reported TECTA mutation leading to the DFNB21 form of hearing impairment among Maghrebian individuals suffering from congenital hearing impairment

  4. the present report suggest that the association of RWDD3 (显示 RWDD3 抗体) and TECTA with paclitaxel-induced peripheral neuropathy may have been a false positive signal

  5. Whole-exome sequencing identifies a novel genotype-phenotype correlation in the entactin (显示 NID1 抗体) domain of the known deafness gene TECTA.

  6. Identified the c.211delC mutation in the KCNQ4 (显示 KCNQ4 抗体) gene and the c.2967C>A (p.H989Q) mutation in the TECTA gene to be associated with high-frequency sensorineural hearing loss in a Japanese family.

  7. A rare novel mutation in TECTA causes autosomal dominant nonsyndromic hearing loss in a Mongolian family.

  8. Data indicate that sequencing of candidate gene TECTA (alpha-tectorin) revealed a heterozygous c.5945C>A substitution in exon 19, causing amino acid substitution of Ala to Asp (显示 ASIP 抗体) at a conservative position 1982.

  9. this study failed to replicate a GWAS reporting an association between the 2 SNPs rs2296308 in RWDD3 (显示 RWDD3 抗体) and rs1829 in the intron of TECTA and time to neuropathy in ovarian cancer patients treated with paclitaxel

  10. we have reported the prevalence of TECTA mutations in Japanese autosomal dominant nonsyndromic hearing loss (ADNSHL) patients detected by genetic screening, and confirmed the genotype-phenotype correlations.

Mouse (Murine) Tectorin alpha (TECTA) interaction partners

  1. Alpha-tectorin and beta-tectorin (显示 TECTB 抗体) crosslink type II collagen (显示 COL2A1 抗体) fibrils and connect the tectorial membrane to the spiral limbus.

  2. Tecta mutant mice all exhibit an enhanced tendency to have audiogenic seizures in response to white noise stimuli.

  3. CEACAM16 (显示 CEACAM16 抗体) can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin (显示 TECTB 抗体) and influences the physical properties of the tectorial membrane

  4. The morphology and mechanical properties of wild-type, heterozygous, and homozygous Tecta tecta membrane, were analysed.

  5. In Tecta(Y)(1870C/+) mice, the tectorin content of the tectorial membrane was reduced, as was the content of glycoconjugates reacting with the lectin wheat germ agglutinin.

  6. The Tecta (A349D/A349D) mouse reveals that missense mutations in Tecta can be recessive and lead to tectorial membrane detachment

TECTA 抗原简介

Antigen Summary

The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.

Alternative names and synonyms associated with TECTA

  • tectorin alpha (TECTA) 抗体
  • tectorin alpha (Tecta) 抗体
  • DFNA8 抗体
  • DFNA12 抗体
  • DFNB21 抗体
  • Tctna 抗体

Protein level used designations for anti-Tectorin alpha (TECTA) 抗体

tectorin alpha , alpha-tectorin-like , alpha-tectorin , [a]-tectorin , alpha tectorin

GENE ID SPECIES
451622 Pan troglodytes
489357 Canis lupus familiaris
712586 Macaca mulatta
100459434 Pongo abelii
100604140 Nomascus leucogenys
7007 Homo sapiens
21683 Mus musculus
300653 Rattus norvegicus
395686 Gallus gallus
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