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抗Human TECTA 抗体:
抗Mouse (Murine) TECTA 抗体:
抗Rat (Rattus) TECTA 抗体:
Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4 (显示 EYA4 抗体)), DFNA8/12 (TECTA), DFNA13 (COL11A2 (显示 COL11A2 抗体)), DFNA44 (CCDC50 (显示 CCDC50 抗体)), have been reported to date. [review]
A novel homozygous variant (c.734G > A) was found in exon 5 of the TECTA gene in one family leading to a nonsense mutation causing autosomal recessive nonsyndromic hearing loss.
To our knowledge, this is the first reported TECTA mutation leading to the DFNB21 form of hearing impairment among Maghrebian individuals suffering from congenital hearing impairment
the present report suggest that the association of RWDD3 (显示 RWDD3 抗体) and TECTA with paclitaxel-induced peripheral neuropathy may have been a false positive signal
Whole-exome sequencing identifies a novel genotype-phenotype correlation in the entactin (显示 NID1 抗体) domain of the known deafness gene TECTA.
Identified the c.211delC mutation in the KCNQ4 (显示 KCNQ4 抗体) gene and the c.2967C>A (p.H989Q) mutation in the TECTA gene to be associated with high-frequency sensorineural hearing loss in a Japanese family.
A rare novel mutation in TECTA causes autosomal dominant nonsyndromic hearing loss in a Mongolian family.
Data indicate that sequencing of candidate gene TECTA (alpha-tectorin) revealed a heterozygous c.5945C>A substitution in exon 19, causing amino acid substitution of Ala to Asp (显示 ASIP 抗体) at a conservative position 1982.
this study failed to replicate a GWAS reporting an association between the 2 SNPs rs2296308 in RWDD3 (显示 RWDD3 抗体) and rs1829 in the intron of TECTA and time to neuropathy in ovarian cancer patients treated with paclitaxel
we have reported the prevalence of TECTA mutations in Japanese autosomal dominant nonsyndromic hearing loss (ADNSHL) patients detected by genetic screening, and confirmed the genotype-phenotype correlations.
Alpha-tectorin and beta-tectorin (显示 TECTB 抗体) crosslink type II collagen (显示 COL2A1 抗体) fibrils and connect the tectorial membrane to the spiral limbus.
Tecta mutant mice all exhibit an enhanced tendency to have audiogenic seizures in response to white noise stimuli.
CEACAM16 (显示 CEACAM16 抗体) can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin (显示 TECTB 抗体) and influences the physical properties of the tectorial membrane
The morphology and mechanical properties of wild-type, heterozygous, and homozygous Tecta tecta membrane, were analysed.
In Tecta(Y)(1870C/+) mice, the tectorin content of the tectorial membrane was reduced, as was the content of glycoconjugates reacting with the lectin wheat germ agglutinin.
The Tecta (A349D/A349D) mouse reveals that missense mutations in Tecta can be recessive and lead to tectorial membrane detachment
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.
, alpha tectorin