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By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA (显示 NTRK1 蛋白) and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC (显示 NTRK3 蛋白) was faintly detected
BDNF (显示 BDNF 蛋白)-TrkB influences the expression level of components of chemokine (显示 CCL1 蛋白) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF (显示 BDNF 蛋白)/TrkB2 system in the adult zebrafish retina.
Study showed that complex relationships exist between BDNF (显示 BDNF 蛋白)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
Data suggest that high expression of TRKB (not TRKA (显示 NTRK1 蛋白) or TRKC (显示 NTRK3 蛋白)) in lung squamous cell carcinoma is correlated with vascular invasion, lymph node metastasis, advanced stage of tumor, and poor prognosis; overall survival of patients with TRKB-high expression is significantly shorter than those with TRKB-low expression; RNA interference against TRKB or BDNF (显示 BDNF 蛋白) (TRKB agonist) inhibits cell proliferation of tumor cell line.
Among the adaptations observed following consumption of drugs of abuse or alcohol abuse, BDNF (显示 BDNF 蛋白) levels are widely altered in both brain and periphery. Data suggest that BDNF (显示 BDNF 蛋白)/TRKB signaling in neurons in specific areas of brain (hippocampus, nucleus accumbens) is altered in protracted withdrawal from drug/alcohol abuse. [REVIEW]
Data suggest that kinase domains of neurotrophin (显示 BDNF 蛋白) receptor isoforms, TRKA (显示 NTRK1 蛋白), TRKB, and TRKC (显示 NTRK3 蛋白), exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan-Trk (显示 NTRK1 蛋白) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
High TRKB expression is associated with Small Cell Lung Cancer.
Co-immunoprecipitation and biochemical fractionation data suggested that p75 (显示 CUX1 蛋白) TM stimulates TrkB phosphorylation at the cell membrane.
High NTRK2 expression is associated with astrocytomas.
overexpression of TrkB, but not of BDNF (显示 BDNF 蛋白), is significantly associated with a poor survival outcome for TNBC patients.
In the current work, we provide a global analysis of the physiological consequences of TrkB receptor activation in vitro and discuss the dynamic consequences of TrkB activation in vivo. Finally, we propose a clinically-feasible option for increasing BDNF (显示 BDNF 蛋白) expression in the hypothalamus to more readily utilize the oncolytic effects of BDNF (显示 BDNF 蛋白).
ShcD (显示 SHC4 蛋白) binds to active Ret (显示 RET 蛋白), TrkA (显示 NTRK1 蛋白), and TrkB neurotrophic factor (显示 NTF3 蛋白) receptors predominantly via its phosphotyrosine-binding (PTB (显示 PTBP1 蛋白)) domain.
BDNF (显示 BDNF 蛋白) acts retrogradely on TrkB in climbing fibers , and facilitates elimination of climbing fibers synapses from Purkinje cells somata during the third postnatal week.
The three receptor sets considered (mAChR (显示 CHRM3 蛋白), AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons
findings show that BDNF (显示 BDNF 蛋白)-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (显示 SREBF2 蛋白). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF (显示 BDNF 蛋白)-TrkB signaling as a pathologic mechanism during periods of chronic stress.
inhibition of Sig (显示 PICALM 蛋白)-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.
After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination.
Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor (显示 BDNF 蛋白) -ERK1/2-cAMP response element-binding protein pathway through tropomyosin receptor kinase (显示 NTRK1 蛋白) B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.
Data show that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport.
findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR (显示 GRIN1 蛋白)-CaMKII (显示 CAMK2G 蛋白)-dependent BDNF (显示 BDNF 蛋白) release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity
Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice.
These observations provided evidence that brain-derived naeurotrophic factor(BDNF (显示 BDNF 蛋白)) and its receptor (BDNF (显示 BDNF 蛋白) receptor) secreted by bovine sperm was important in regulation of insulin (显示 INS 蛋白) and leptin (显示 LEP 蛋白).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (显示 BDNF 蛋白)-Trk-B
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
neurotrophin receptor B xTrkB-alpha
, BDNF/NT-3 growth factors receptor
, neurotrophic tyrosine kinase, receptor, type 2
, BDNF/NT-3 growth factors receptor-like
, neurotrophic tyrosine kinase receptor type 2
, trkB tyrosine kinase
, tyrosine kinase receptor
, BDNF-tropomyosine receptor kinase B
, tropomyosin-related kinase B
, tyrosine kinase receptor B
, neural receptor protein-tyrosine kinase (trkB)
, trkB protein