TRKB 蛋白 (NTRK2)产品概述

在www.antibodies-online.cn可供38 Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) 蛋白的13不同的供货商。 再加上,我们可以发TRKB 抗体 (355)TRKB 试剂盒 (50)和数多这个蛋白质的别的产品。 总共469 TRKB产品已列进来了。
别名:
AI848316, C030027L06Rik, GP145-TrkB, ntrk2, RATTRKB1, si:ch211-220b11.1, Tkrb, Trk-B, TrkB, trkb-b, TRKB1, trkB2, xtrkb
列出全部蛋白 基因 基因ID UniProt
NTRK2 4915 Q16620
NTRK2 18212 P15209
NTRK2 25054 Q63604

按照种类TRKB 蛋白 (NTRK2)

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Zebrafish Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA (显示 NTRK1 蛋白) and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC (显示 NTRK3 蛋白) was faintly detected

  2. BDNF (显示 BDNF 蛋白)-TrkB influences the expression level of components of chemokine (显示 CCL1 蛋白) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

  3. Light regulates the expression of the BDNF (显示 BDNF 蛋白)/TrkB2 system in the adult zebrafish retina.

Rhesus Monkey Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. Study showed that complex relationships exist between BDNF (显示 BDNF 蛋白)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

Human Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. overexpression of TrkB, but not of BDNF (显示 BDNF 蛋白), is significantly associated with a poor survival outcome for TNBC patients.

  2. In the current work, we provide a global analysis of the physiological consequences of TrkB receptor activation in vitro and discuss the dynamic consequences of TrkB activation in vivo. Finally, we propose a clinically-feasible option for increasing BDNF (显示 BDNF 蛋白) expression in the hypothalamus to more readily utilize the oncolytic effects of BDNF (显示 BDNF 蛋白).

  3. ShcD (显示 SHC4 蛋白) binds to active Ret (显示 RET 蛋白), TrkA (显示 NTRK1 蛋白), and TrkB neurotrophic factor (显示 NTF3 蛋白) receptors predominantly via its phosphotyrosine-binding (PTB (显示 PTBP1 蛋白)) domain.

  4. These findings, while exploratory, indicate that the genotypes of NTRK2 and COMT (显示 COMT 蛋白) may contribute to relative risk for symptom burden during and shortly after the period of chemotherapy in women with early stage breast cancer.

  5. We demonstrated that downregulation of PHLDA1 (显示 PHLDA1 蛋白) leads to a significant increase in expression of Aurora A (显示 AURKA 蛋白) and TRKB that are markers of poor prognosis in neuroblastoma (显示 ARHGEF16 蛋白)

  6. The receptors, TrkB and p75 (显示 CUX1 蛋白) are more highly expressed in deep infiltrating endometriosis than in peritoneal tissues.

  7. High expression of NTRK2 is associated with gastric cancer.

  8. Genetic variability of NTRK2, a susceptibility gene for psychiatric disorders, is related to emotional arousal and-independently-to brain white-matter properties in healthy individuals.

  9. High expression of TrkA (显示 NTRK1 蛋白), TrkB, or TrkC (显示 NTRK3 蛋白) was significantly associated with histopathology

  10. Results show up-regulation of TrkB and down-regulation of Runx3 (显示 RUNX3 蛋白) and Keap1 (显示 KEAP1 蛋白) in breast cancer cells and suggest that TrkB plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 (显示 RUNX3 蛋白) or Keap1 (显示 KEAP1 蛋白).

Mouse (Murine) Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. findings show that BDNF (显示 BDNF 蛋白)-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (显示 SREBF2 蛋白). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF (显示 BDNF 蛋白)-TrkB signaling as a pathologic mechanism during periods of chronic stress.

  2. inhibition of Sig (显示 PICALM 蛋白)-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.

  3. After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination.

  4. Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor (显示 BDNF 蛋白) -ERK1/2-cAMP response element-binding protein pathway through tropomyosin receptor kinase (显示 NTRK1 蛋白) B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.

  5. Data show that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport.

  6. findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR (显示 GRIN1 蛋白)-CaMKII (显示 CAMK2G 蛋白)-dependent BDNF (显示 BDNF 蛋白) release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity

  7. Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice.

  8. Results suggest that the therapeutic actions of atypical antidepressant drugs involve various neurocircuits, some of which, but not all, appears to involve BDNF (显示 BDNF 蛋白)/TrkB and downstream neuroplastic signaling

  9. Observations provide evidence that female-specific induction of estrogen receptor alpha (显示 ESR1 蛋白) expression confers neuroprotection with TrkB agonist therapy via Src (显示 SRC 蛋白) family kinase activation and account for improved functional outcomes in female neonates post-hypoxia and ischemia.

  10. data suggest antidepressant effects of BDNF (显示 BDNF 蛋白)-TrkB in the NAc, which could not be explained by activation of the transcription factors CREB (显示 CREB1 蛋白) or beta-catenin (显示 CTNNB1 蛋白). The effects TrkB has on depression-related behavior in different brain regions appear to critically depend on the targeted cell type.

Cow (Bovine) Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF (显示 BDNF 蛋白)) and its receptor (BDNF (显示 BDNF 蛋白) receptor) secreted by bovine sperm was important in regulation of insulin (显示 INS 蛋白) and leptin (显示 LEP 蛋白).

  2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (显示 BDNF 蛋白)-Trk-B

蛋白简介TRKB (NTRK2)

蛋白简介

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TRKB (NTRK2)

  • neurotrophic tyrosine kinase, receptor, type 2 (NTRK2)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2-b)
  • neurotrophic tyrosine kinase, receptor, type 2b (ntrk2b)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2-a)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2)
  • neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2)
  • AI848316 蛋白
  • C030027L06Rik 蛋白
  • GP145-TrkB 蛋白
  • ntrk2 蛋白
  • RATTRKB1 蛋白
  • si:ch211-220b11.1 蛋白
  • Tkrb 蛋白
  • Trk-B 蛋白
  • TrkB 蛋白
  • trkb-b 蛋白
  • TRKB1 蛋白
  • trkB2 蛋白
  • xtrkb 蛋白

Protein level used designations for NTRK2

neurotrophin receptor B xTrkB-alpha , BDNF/NT-3 growth factors receptor , neurotrophic tyrosine kinase, receptor, type 2 , BDNF/NT-3 growth factors receptor-like , neurotrophic tyrosine kinase receptor type 2 , trk-B , trkB tyrosine kinase , tyrosine kinase receptor , BDNF-tropomyosine receptor kinase B , tropomyosin-related kinase B , tyrosine kinase receptor B , GP145-TrkB/GP95-TrkB , neural receptor protein-tyrosine kinase (trkB) , trkB protein

GENE ID SPECIES
100061700 Equus caballus
379266 Xenopus laevis
570240 Danio rerio
709757 Macaca mulatta
735394 Pan troglodytes
779173 Xenopus laevis
780110 Xenopus (Silurana) tropicalis
100388984 Callithrix jacchus
100441207 Pongo abelii
396157 Gallus gallus
4915 Homo sapiens
18212 Mus musculus
25054 Rattus norvegicus
484147 Canis lupus familiaris
505824 Bos taurus
100352548 Oryctolagus cuniculus
100723565 Cavia porcellus
100519209 Sus scrofa
101116015 Ovis aries
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