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Human TEK ELISA Kit for Sandwich ELISA - ABIN625097
Zhang, Lin, Jiang, Xu, Luo, Mo, Li, Chen: Extensive serum biomarker analysis in patients with ST segment elevation myocardial infarction (STEMI). in Cytokine 2015
Human TEK ELISA Kit for Sandwich ELISA - ABIN411357
Zheng, Zhu, Bai, Wu, Jia, Hu: Exercise improves recovery after ischemic brain injury by inducing the expression of angiopoietin-1 and Tie-2 in rats. in The Tohoku journal of experimental medicine 2011
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Together, these results imply that Tie2 is essential for venous specification and maintenance via Akt (显示 AKT1 ELISA试剂盒) mediated stabilization of COUP-TFII (显示 NR2F2 ELISA试剂盒).
These results indicate that the Angpt-Tie2 system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma.
TEK mutations have a role in primary congenital glaucoma with variable expressivity
ANG2 (显示 ANGPT2 ELISA试剂盒) activation of Tie2 supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (显示 TIE1 ELISA试剂盒) in inflammation leads to ANG2 (显示 ANGPT2 ELISA试剂盒) antagonism of Tie2 and initiates a positive feedback loop wherein FOXO1 (显示 FOXO1 ELISA试剂盒)-driven ANG2 (显示 ANGPT2 ELISA试剂盒) expression promotes vascular remodeling and leakage
Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoi (显示 ANGPT1 ELISA试剂盒)etin 1/ Tie-2 signaling pathway.
TBMS1 further stimulated the proteasomal degradation of vascular endothelial growth factor receptor-2 (VEGFR2 (显示 KDR ELISA试剂盒)) and Tie2 in endothelial cells, which down-regulated AKT (显示 AKT1 ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) signaling.
results implicate common genetic variation at the TIE2 locus as a determinant of vascular leak-related clinical outcomes from common infections, suggesting new tools to identify individuals at unusual risk for deleterious complications of infection
the results suggest that an increased level of TNF-alpha (显示 TNF ELISA试剂盒) together with concomitant upregulation of Tie2/Angiopoietin signaling have critical roles in severe dengue infection.
Data support an interactive model of Tie1 (显示 TIE1 ELISA试剂盒) and Tie2 function, in which dynamically regulated Tie1 (显示 TIE1 ELISA试剂盒) versus Tie2 expression determines the net positive or negative effect of Tie1 (显示 TIE1 ELISA试剂盒) on Tie2 signaling.
These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (显示 VCAM1 ELISA试剂盒).
IL-6 (显示 IL6 ELISA试剂盒) and TIE2 polymorphisms are associated with baseline peritoneal transport property.
Results show that TIE2 phosphorylates caveolin-1 (显示 CAV1 ELISA试剂盒) at Tyr14, and associates with caveolin-1 (显示 CAV1 ELISA试剂盒) in caveolae. Also, its nuclear translocation is caveolin-1 (显示 CAV1 ELISA试剂盒) dependent.
Tie1 (显示 TIE1 ELISA试剂盒) directly interacts with Tie2 to promote ANG (显示 ANG ELISA试剂盒)-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 (显示 TIE1 ELISA试剂盒) cleavage contributes to loss of ANG2 (显示 ANGPT2 ELISA试剂盒) agonist activity and vascular stability
ANG-1 (显示 ANGPT1 ELISA试剂盒), ANG-2 (显示 ANGPT2 ELISA试剂盒) and TIE-2 levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception.
Our data suggest that interaction of TEK and CYP1B1 (显示 CYP1B1 ELISA试剂盒) contributes to primary congenital glaucoma pathogenesis and argue that TEK-CYP1B1 (显示 CYP1B1 ELISA试剂盒) may perform overlapping as well as distinct functions in manifesting the disease etiology.
High Tie-2 expression is associated with Primary Myelofibrosis.
In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 (显示 ANGPT1 ELISA试剂盒) and Ang-2 (显示 ANGPT2 ELISA试剂盒) may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer.
Data show that fibulin-5 (显示 FBLN5 ELISA试剂盒) strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1 (显示 ANGPT1 ELISA试剂盒)/TIE-2 receptor axis.
Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
observations demonstrate that Tie2 is an important regulator of tip cell behaviors
Tie-1 (显示 TIE1 ELISA试剂盒) and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations\; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
growth factor receptor Tie2/Tek
, TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
, Angiopoietin-1 receptor
, TEK tyrosine kinase, endothelial
, angiopoietin-1 receptor-like
, angiopoietin-1 receptor
, endothelial tyrosine kinase
, p140 TEK
, tunica interna endothelial cell kinase
, tyrosine kinase with Ig and EGF homology domains-2
, tyrosine-protein kinase receptor TEK
, tyrosine-protein kinase receptor TIE-2
, soluble TIE2 variant 1
, soluble TIE2 variant 2
, protein-tyrosine kinase Tie2
, endothelial-specific receptor tyrosine kinase
, tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2
, endothelium-specific receptor tyrosine kinase 2
, tyrosine-protein kinase receptor Tie-2