anti-Core-Binding Factor, beta Subunit (CBFB) 抗体产品概述

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anti-Core-Binding Factor, beta Subunit 抗体 (CBFB)
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别名:
AI893578, CBF-B, cbf-beta, Cbfb, cbfbeta, Nfya, PEA2, pea2-beta, Pebp2, pebp2-beta, PEBP2B, Pebpb2, unp1266

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引用最多的anti-Core-Binding Factor, beta Subunit 抗体

  1. Human Polyclonal CBFB Primary Antibody for IHC, ELISA - ABIN1533882 : Hajra, Collins: Structure of the leukemia-associated human CBFB gene. in Genomics 1995 (PubMed)
    Show all 2 references for 1533882

  2. Human Polyclonal CBFB Primary Antibody for FACS, IF - ABIN390892 : Andersen, Christensen, Thorsen, Schepeler, Sørensen, Verspaget, Simon, Kruhøffer, Aaltonen, Laurberg, Ørntoft: Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. in British journal of cancer 2009 (PubMed)

更多抗Core-Binding Factor, beta Subunit的相互作用对抗体

Rhesus Monkey Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. Vif (显示 BTG1 抗体) proteins of human and simian immunodeficiency viruses require cellular CBFbeta to degrade APOBEC3G (显示 APOBEC3G 抗体).

  2. simian immunodeficiency virus (SIV) Vif (显示 BTG1 抗体) binds to and requires CBF-beta to degrade rhesus macaque APOBEC3G (显示 APOBEC3G 抗体)

Mouse (Murine) Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. High CBFB expression is associated with leukemia.

  2. Vif (显示 BTG1 抗体) stabilization by CBFbeta is mainly caused by impairing MDM2 (显示 MDM2 抗体)-mediated degradation.

  3. the mechanistic view that the proliferative function of Crlz-1 (显示 UTP3 抗体) is caused by relaying Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) to pre-B cell receptor signaling pathways through the regulation of Runx/CBFbeta heterodimerization was verified

  4. Core binding factor beta deficiency in chondrocytes caused a decrease of protein levels of Runx transcription factors by accelerating polyubiquitination-mediated proteosomal degradation in vitro

  5. Cbfb plays an important role in the stabilization of Runx family proteins; and that Runx2 (显示 RUNX2 抗体) protein stability is less dependent on Cbfb in calvariae than in cartilaginous limb skeletons

  6. findings indicate that Cbfbeta stabilizes Runx2 (显示 RUNX2 抗体) in osteoblasts by forming a complex and thus facilitates the proper maintenance of bone mass, particularly cortical bone

  7. Runx/Cbfb signaling regulate androgen receptor (显示 AR 抗体) pathway, but does not affect the circulating testosterone levels or the enzymatic conversion to DHT.

  8. Cbfb deficiency results in differentiation blocks and stem cell expansion in hematopoiesis.

  9. Cbfbeta functions in upregulating Ihh (显示 IHH 抗体) expression to promoter chondrocyte proliferation and osteoblast differentiation, and inhibiting PPR (显示 PTH1R 抗体) expression to enhance chondrocyte differentiation.

  10. results demonstrate that Cbfbeta mediates cartilage and bone development by interacting with Runx1 (显示 RUNX1 抗体) and Runx2 (显示 RUNX2 抗体) to regulate the expressions of Col (显示 HDAC1 抗体) X and Osx (显示 SP7 抗体) for chondrocyte and osteoblast development

Zebrafish Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 (显示 RUNX3 抗体) expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 (显示 RUNX3 抗体) activity.

  2. characterization of cbfbeta gene

  3. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  4. Data demonstrate for the first time an essential role of JunB (显示 JUNB 抗体)-CBFbeta signaling for maintaining sarcomere architecture and function.

Human Core-Binding Factor, beta Subunit (CBFB) interaction partners

  1. The co-existence of BCR (显示 BCR 抗体)-ABL1 (显示 ABL1 抗体) and CBFB rearrangement is associated with poor outcome and a clinical course similar to that of CML (显示 BCR 抗体)-BP, and unlike de novo AML (显示 RUNX1 抗体) with CBFB rearrangement, suggesting that high-intensity chemotherapy with TKI should be considered in these patients.

  2. Moreover, using a CBF-beta loss-of-function mutant, the authors demonstrated that the interaction between CBF-beta and Vif (显示 BTG1 抗体) was not sufficient for Vif (显示 BTG1 抗体) assistance; a region including F68 in CBF-beta was also required for the stability and function of Vif (显示 BTG1 抗体).

  3. Vif (显示 BTG1 抗体) stabilization by CBFbeta is mainly caused by impairing MDM2 (显示 MDM2 抗体)-mediated degradation.

  4. Mutational analysis of CBFbeta revealed that F68 and I55 (显示 FBXL14 抗体) residues are important and participate in a tripartite hydrophobic interaction with W5 of Vif (显示 BTG1 抗体) to maintain a stable and functional Vif (显示 BTG1 抗体)-CBFbeta complex.

  5. Thus, an NGF (显示 NGFB 抗体)/TrkA (显示 NTRK1 抗体)-MAPK (显示 MAPK1 抗体)-CBFbeta pathway converges with Islet1 (显示 ISL1 抗体)-Runx1 (显示 RUNX1 抗体) signaling to promote Runx1 (显示 RUNX1 抗体)/CBFbeta holocomplex formation and nonpeptidergic nociceptor maturation.

  6. Our findings demonstrate that HSPCs exposed to non-cytotoxic levels of environmental chemicals and chemotherapeutic agents are prone to topoisomerase II (显示 TOP2 抗体)-mediated DNA damage at the leukemia-associated genes MLL (显示 MLL 抗体) and CBFB.

  7. These results provide important information on the assembly of the Vif (显示 BTG1 抗体)-CUL5 (显示 CUL5 抗体)-E3 ubiquitin ligase (显示 MUL1 抗体) and identify a new viV binding interface with CBF-beta at the C-terminus of HIV-1 Vif (显示 BTG1 抗体).

  8. CBF-beta promoted steady-state levels of HIV-1 Vif (显示 BTG1 抗体) by inhibiting the degradation of HIV-1 Vif (显示 BTG1 抗体) through the proteasome pathway.

  9. CBFB contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB-SMMHC (显示 MYH11 抗体) in proliferation and maintenance of the leukemic phenotype.

  10. we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation

Core-Binding Factor, beta Subunit (CBFB) 抗原简介

Antigen Summary

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit\; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16

Alternative names and synonyms associated with Core-Binding Factor, beta Subunit (CBFB)

  • core-binding factor, beta subunit (Cbfb) 抗体
  • core-binding factor, beta subunit (CBFB) 抗体
  • core-binding factor, beta subunit (LOC100230400) 抗体
  • core-binding factor, beta subunit (cbfb) 抗体
  • core binding factor beta subunit (Cbfb) 抗体
  • core-binding factor, beta subunit (LOC100340362) 抗体
  • core-binding factor, beta subunit (LOC100359284) 抗体
  • core binding factor beta (Cbfb) 抗体
  • nuclear transcription factor-Y alpha (Nfya) 抗体
  • nuclear transcription factor-Y beta (Nfyb) 抗体
  • AI893578 抗体
  • CBF-B 抗体
  • cbf-beta 抗体
  • Cbfb 抗体
  • cbfbeta 抗体
  • Nfya 抗体
  • PEA2 抗体
  • pea2-beta 抗体
  • Pebp2 抗体
  • pebp2-beta 抗体
  • PEBP2B 抗体
  • Pebpb2 抗体
  • unp1266 抗体

Protein level used designations for CBFB

core binding factor beta , core-binding factor subunit beta , core-binding factor, beta subunit , core binding factor beta subunit , CBF-beta , PEA2-beta , PEBP2-beta , SL3-3 enhancer factor 1 subunit beta , SL3/AKV core-binding factor beta subunit , polyomavirus enhancer-binding protein 2 beta subunit , CCAAT-binding transcription factor subunit B , core-binding factor beta , SL3-3 enhancer factor 1 beta subunit , polyomavirus enhancer binding protein 2, beta subunit , CAAT box DNA-binding protein subunit A , CAAT-box DNA-binding protein subunit A , CBF-B , NF-YA , nuclear transcription factor Y subunit A , nuclear transcription factor Y subunit alpha , CAAT box DNA-binding protein subunit B , CAAT-box DNA-binding protein subunit B , CBF-A , CCAAT binding transcription factor of CBF-B/NFY-B , CCAAT-binding transcription factor subunit A , NF-YB , nuclear transcription factor - Y beta , nuclear transcription factor Y subunit B , nuclear transcription factor Y subunit beta

GENE ID SPECIES
361391 Rattus norvegicus
695767 Macaca mulatta
100230400 Taeniopygia guttata
100270773 Xenopus (Silurana) tropicalis
100313579 Saccoglossus kowalevskii
100340362 Oryctolagus cuniculus
100359284 Oryctolagus cuniculus
12400 Mus musculus
30744 Danio rerio
446882 Xenopus laevis
395257 Gallus gallus
865 Homo sapiens
479690 Canis lupus familiaris
614678 Bos taurus
29508 Rattus norvegicus
25336 Rattus norvegicus
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