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Mean eotaxin 2 concentrations in nasal fluid in patients with perennial allergic rhinitis and nonallergic and allergic chronic rhinosinusitis with nasal polyps patients were significantly higher in comparison to control subjects.
Review: eotaxins (CCL11, CCL24, and CCL26 (显示 CCL26 蛋白)) play key role(s) during symptomatic inflammatory responses raised in response to allergic crisis of allergic asthma and atopic dermatitis
HMGB1 (显示 HMGB1 蛋白) did not elicit chemotaxis of human eosinophils alone and had no effect in combination with the eosinophil chemotactic agent, eotaxin-2 (CCL24).
these data suggest that CCL26 and CCL24 are likely involved in the pathogenesis of chronic nasal hypereosinophilia, with a complex cooperation and different involvement of the various members of eotaxin family.
CCL11, CCL24, and CCL26 (显示 CCL26 蛋白) are increased in TB patients; hence, it seems that TB suppresses Th1 (显示 TH1L 蛋白) and the classic function of macrophages subsequently by inducing the chemokines' expression
CCL11, CCL24, and CCL26 (显示 CCL26 蛋白) has a role in the recruitment of extravillous trophoblast into decidual tissue and vessels.
Pregnancy associated environments increased local CCL24/CCR3 (显示 CCR3 蛋白), supporting the process of decidualization in human early pregnancy.
Phosphodiesterase 4 inhibitors, rolipram and RO-20-1724 have no effect on CCL24 expression in human primary bronchial epithelial cells.
The level of eotaxin expression and inflammatory cell count were measured in the material from nasal brushing in healthy controls and in patients with allergic rhinitis, asthma, and chronic obstructive pulmonary disease.
Study shows that CCL24 levels were significantly increased in age-related macular degeneration (AMD (显示 AMD1 蛋白)) patients despite Avastin treatment as compared with normal controls and those without Avastin.
the increased airway eosinophils and mucous cell metaplasia in house dust mite-challenged Cd163 (显示 CD163 蛋白)-/- mice are mediated by augmented CCL24 production
TPL-2 (显示 MAP3K8 蛋白)-regulated Ccl24 in CD11c (显示 ITGAX 蛋白)+CD11b (显示 ITGAM 蛋白)+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.
this study shows that TPL-2 (显示 MAP3K8 蛋白) inhibits Ccl24 expression in lung dendritic cells, and blockade of Ccl24 prevents the exaggerated airway eosinophilia and lung inflammation in mice given house dust mites-pulsed Map3k8 (显示 MAP3K8 蛋白)-/- dendritic cells
production in M-CSF (显示 CSF1R 蛋白)-induced bone marrow-derived macrophages is synergistically induced by IL-4 (显示 IL4 蛋白) and IL-10 (显示 IL10 蛋白)
Autologous transfer of peritoneal macrophages in to the airways of asthmatic mice reduces eotaxin production.
Data indicate that eotaxin 2 (CCL-24), which is known to influence eosinophil migration, was highly up-regulated in broncho-alveolar macrophages (BAMs).
The oesophageal production of CCL24 upon IL-13 (显示 IL13 蛋白) stimulation is sufficient to promote eosinophil migration.
Results demonstrate a cooperative mechanism between interleukin-13 (显示 IL13 蛋白) and eotaxin-2, where IL-13 (显示 IL13 蛋白) mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13 (显示 IL13 蛋白)-induced airway eosinophilia.
Distinct acidic and basic residues within CCR3 (显示 CCR3 蛋白) determine both receptor expression and activation by the eotaxins.
The eotaxin-2 pathway plays a fundamental role in eosinophil recruitment during ovalbumin (显示 OVA 蛋白)-induced experimental asthma.
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line.
C-C motif chemokine 24
, eosinophil chemotactic protein 2
, myeloid progenitor inhibitory factor 2
, small inducible cytokine subfamily A (Cys-Cys), member 24
, small-inducible cytokine A24
, CC chemokine CCL24
, small inducible cytokine A24
, eotaxin-2-like protein
, eosinophil chemotactic protein-2
, small chemokine ligand 24