anti-PDPK1 (PDPK1) 抗体产品概述

Full name:
anti-3-phosphoinositide Dependent Protein Kinase-1 抗体 (PDPK1)
在www.antibodies-online.cn可供467 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) 抗体的31不同的供货商。 再加上,我们可以发PDPK1 蛋白 (28)PDPK1 试剂盒 (25)和数多这个蛋白质的别的产品。 总共551 PDPK1产品已列进来了。
别名:
1210, BG02759, CG1201, CG1210, Dmel\\CG1210, dPDK-1, dPDK1, dSTPK61, MGC82080, PDK, PDK-1, Pdk1, PDK1/Pk61C, pdpk1, PDPK2, pk61c, Pk61C/PDK1, PRO0461, zgc:153787

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  1. Human Polyclonal PDPK1 Primary Antibody for EIA - ABIN358390 : Nilsen, Slagsvold, Skjerpen, Brech, Stenmark, Olsnes: Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358390

  2. Human Polyclonal PDPK1 Primary Antibody for IF, IHC (p) - ABIN196616 : Scheid, Parsons, Woodgett: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for 196616

  3. Human Polyclonal PDPK1 Primary Antibody for ICC, IF - ABIN250776 : Tsoi, Li, Chen, Lau, Tsui, Chan: The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling. in The Biochemical journal 2014 (PubMed)
    Show all 3 references for 250776

  4. Human Polyclonal PDPK1 Primary Antibody for EIA, WB - ABIN359095 : Frödin, Antal, Dümmler, Jensen, Deak, Gammeltoft, Biondi: A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. in The EMBO journal 2002 (PubMed)
    Show all 3 references for 359095

  5. Human Polyclonal PDPK1 Primary Antibody for ELISA, WB - ABIN185505 : Sarbassov, Guertin, Ali, Sabatini: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. in Science (New York, N.Y.) 2005 (PubMed)

  6. Human Polyclonal PDPK1 Primary Antibody for IHC, ELISA - ABIN1532025 : Stephens, Anderson, Stokoe, Erdjument-Bromage, Painter, Holmes, Gaffney, Reese, McCormick, Tempst, Coadwell, Hawkins: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. in Science (New York, N.Y.) 1998 (PubMed)

  7. Cow (Bovine) Polyclonal PDPK1 Primary Antibody for WB - ABIN2779320 : Lin, Hsieh, Song, Lin: Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. in British journal of cancer 2005 (PubMed)

  8. Human Polyclonal PDPK1 Primary Antibody for IF (p), IHC (p) - ABIN744668 : Lin, Lin, Kang, Liu, Wang, Zheng, Yu, Lin: Similar PDK1-AKT-mTOR pathway activation in balloon cells and dysmorphic neurons of type II focal cortical dysplasia with refractory epilepsy. in Epilepsy research 2015 (PubMed)

  9. Cow (Bovine) Polyclonal PDPK1 Primary Antibody for WB - ABIN2777432 : Ohba, Watanabe, Murakami, Radovanovic, Iino, Ishida, Tosa, Ono, Ito: Amlodipine inhibits cell proliferation via PKD1-related pathway. in Biochemical and biophysical research communications 2008 (PubMed)

更多抗PDPK1的相互作用对抗体

Fruit Fly (Drosophila melanogaster) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. PDK1 is also a presynaptic protein, though it is distributed more broadly.

  2. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase (显示 CDK7 抗体) 1, dPDK1

Mouse (Murine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Data indicate that mammary-specific ablation of 3-phosphoinositide dependent protein kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model.

  2. PDK1 was highly expressed in synovia of collagen-induced-arthritis mice com (显示 IL1B 抗体)pared to (显示 IL6 抗体)control. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up- (显示 RPS6KA3 抗体)regulated in CIA compared with normal. This indicated that PDK1/RSK2 may participate in inflammatory pro (显示 TNF 抗体)gress of RA.

  3. PDK1 is required for Ca(2 (显示 CA2 抗体)+)-dependent platelet activation on stimulation of collagen receptor (显示 ITGA2 抗体) glycoprotein VI, arterial thrombotic occlusion, and ischemic stroke in vivo.

  4. In conclusion, we have identified that ARL15 acts as an insulin (显示 INS 抗体)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (显示 IRS1 抗体)/PDPK1/AKT (显示 AKT1 抗体) insulin (显示 INS 抗体) pathway by interacting with its GAP ASAP2 (显示 ASAP2 抗体) and activating PDPK1. This research may provide new insights into GTPase (显示 RACGAP1 抗体)-mediated insulin (显示 INS 抗体) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (显示 INS 抗体) sensitizati

  5. Only when suboptimal doses of Akt (显示 AKT1 抗体)-Pdpk1 interaction inhibitor NSC156529 were used an additive effect with Notch (显示 NOTCH1 抗体) inhibition was seen. We conclude that the Akt (显示 AKT1 抗体) pathway inhibitor NSC156529 is potentially useful as single treatment for liver tumors with hyperactivated Akt (显示 AKT1 抗体) signaling.

  6. Xanthium strumarium methanolic extract exerts anti-inflammatory activity in vitro and in vivo by inhibiting PDK1 kinase activity and blocking signaling to its downstream transcription factor, NF-kappaB (显示 NFKB1 抗体).

  7. PDPK1 is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function.

  8. The PDK1 knock-in mice displayed a reduced brain size due to a reduction in neuronal cell size rather than cell number.

  9. PDK1 is an important regulator in arterial thrombosis formation.

  10. PDK1 is essential for BCR (显示 BCR 抗体)-induced signal transduction to Foxo (显示 FOXO3 抗体) and NF-kappaB (显示 NFKB1 抗体) and is indispensable for both resting and activated B cell survival.

Human 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. Highly expressed PDK1 (显示 PDK1 抗体) could promote cell invasion and secretion of IL-1beta (显示 IL1B 抗体) and IL-6 (显示 IL6 抗体) in human rheumatoid arthritis synovial MH7A cells. Inhibition of RSK2 (显示 RPS6KA3 抗体) reduced the PDK1 (显示 PDK1 抗体)-induced cell invasion and cytokines secretion in MH7A cells. In response to TNF-alpha (显示 TNF 抗体), PDK1 (显示 PDK1 抗体) could phosphorylate RSK2 (显示 RPS6KA3 抗体) and activated RSK2 (显示 RPS6KA3 抗体), then promoting the activation of NF-kappaB (显示 NFKB1 抗体).

  2. In cancer cells resistant to PI3Kalpha (显示 PIK3CA 抗体) inhibition, PDK1 (显示 PDK1 抗体) blockade restores sensitivity to these therapies. SGK1 (显示 SGK1 抗体), which is activated by PDK1 (显示 PDK1 抗体), contributes to the maintenance of residual mTORC1 activity through direct phosphorylation and inhibition of TSC2 (显示 TSC2 抗体).

  3. Results suggest that Ser (显示 SIGLEC1 抗体)-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1 (显示 PDK1 抗体)-PKCtheta (显示 PRKCQ 抗体);-mediated T cell activation.

  4. Elevated expression of PDK1 (显示 PDK1 抗体) was an independent negative prognostic factor of gastric carcinoma.

  5. miR (显示 MLXIP 抗体)-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1 (显示 PDK1 抗体).

  6. miR (显示 MLXIP 抗体)-454 functions as a tumor suppressor in glioblastoma, inhibiting proliferation of human glioblastoma cells by suppressing PDK1 (显示 PDK1 抗体) expression.

  7. Decreased PDK1 (显示 PDK1 抗体) level is closely associated with reduced Akt (显示 AKT1 抗体)/cyclin D1 (显示 CCND1 抗体) activity.

  8. MiR (显示 MLXIP 抗体)-138 regulation of PI3K (显示 PIK3CA 抗体) signaling in ASMCs by altering the expression of PDK1 (显示 PDK1 抗体).

  9. Dephosphorylation of PDK-1 (显示 PDK1 抗体) and the resulting changes to Akt (显示 AKT1 抗体) phosphorylation is one of the mechanisms by which infection with Helicobacter pylori alter the balance between apoptosis and cell proliferation.

  10. Data suggest that claudin-18 (显示 CLDN18 抗体) suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of phosphoinositide-dependent protein kinase (显示 CDK7 抗体)-1 and proto-oncogene (显示 RAB1A 抗体) protein c (显示 PROC 抗体)-akt (Akt (显示 AKT1 抗体)).

Pig (Porcine) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. miR (显示 MYLIP 抗体)-375 directly targeted PDK1 (显示 PDK1 抗体) in porcine pancreatic stem cells suppressing cell proliferation and differentiation into islet-like cells.

Caenorhabditis elegans (C. elegans) 3-phosphoinositide Dependent Protein Kinase-1 (PDPK1) interaction partners

  1. at least three C. elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34 (显示 PIK3C3 抗体) (PI3K)

PDPK1 抗原简介

Antigen Summary

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

Alternative names and synonyms associated with PDPK1

  • 3-phosphoinositide dependent protein kinase-1 (PDPK1) 抗体
  • 3-phosphoinositide dependent protein kinase-1 (pdpk1) 抗体
  • 3-phosphoinositide dependent protein kinase-1 (Pdpk1) 抗体
  • 3-phosphoinositide dependent protein kinase 1 (Pdpk1) 抗体
  • 3-phosphoinositide dependent protein kinase-1a (pdpk1a) 抗体
  • 3-phosphoinositide-dependent protein kinase 1 (pdpk1) 抗体
  • Phosphoinositide-dependent kinase 1 (Pdk1) 抗体
  • Protein PDK-1 (pdk-1) 抗体
  • 1210 抗体
  • BG02759 抗体
  • CG1201 抗体
  • CG1210 抗体
  • Dmel\\CG1210 抗体
  • dPDK-1 抗体
  • dPDK1 抗体
  • dSTPK61 抗体
  • MGC82080 抗体
  • PDK 抗体
  • PDK-1 抗体
  • Pdk1 抗体
  • PDK1/Pk61C 抗体
  • pdpk1 抗体
  • PDPK2 抗体
  • pk61c 抗体
  • Pk61C/PDK1 抗体
  • PRO0461 抗体
  • zgc:153787 抗体

Protein level used designations for PDPK1

3-phosphoinositide-dependent protein kinase 1 , 3-phosphoinositide dependent protein kinase-1 , pkB kinase , protein kinase B kinase , PkB kinase like gene 1 , Pkb kinase , mPDK1 , CG1210-PA , CG1210-PB , CG1210-PC , CG1210-PD , CG1210-PE , CG1210-PF , CG1210-PG , CG1210-PH , CG1210-PI , CG1210-PJ , Pdk1-PA , Pdk1-PB , Pdk1-PC , Pdk1-PD , Pdk1-PE , Pdk1-PF , Pdk1-PG , Pdk1-PH , Pdk1-PI , Pdk1-PJ , phosphoinositide dependent kinase 1 , phosphoinositide-dependent kinase 1 , protein kinase 61C , serine/threonine protein kinase

GENE ID SPECIES
416588 Gallus gallus
444529 Xenopus laevis
479875 Canis lupus familiaris
100138102 Bos taurus
100192445 Sus scrofa
779524 Xenopus (Silurana) tropicalis
81745 Rattus norvegicus
5170 Homo sapiens
18607 Mus musculus
768202 Danio rerio
100380750 Salmo salar
38017 Drosophila melanogaster
180475 Caenorhabditis elegans
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