Carboxypeptidase E 蛋白 (CPE)产品概述

Full name:
Carboxypeptidase E 蛋白 (CPE)
在www.antibodies-online.cn可供28 Carboxypeptidase E (CPE) 蛋白的11不同的供货商。 再加上,我们可以发Carboxypeptidase E 抗体 (89)Carboxypeptidase E 试剂盒 (17)和数多这个蛋白质的别的产品。 总共142 Carboxypeptidase E产品已列进来了。
CARBE, CPE, Cph, Cph-1, Cph1, fat, R74677, si:ch211-198g9.2, zgc:85981
列出全部蛋白 基因 基因ID UniProt
CPE 1363 P16870
CPE 12876 Q00493
CPE 25669 P15087


按照种类Carboxypeptidase E 蛋白 (CPE)


引用最多的Carboxypeptidase E 蛋白

  1. Human CPE Protein expressed in Human Cells - ABIN2002009 : Cool, Normant, Shen, Chen, Pannell, Zhang, Loh: Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. in Cell 1997 (PubMed)
    Show all 5 references for 2002009

  2. Mouse (Murine) CPE Protein expressed in HEK-293 Cells - ABIN2180680 : Manser, Fernandez, Loo, Goh, Monfries, Hall, Lim: Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. in The Biochemical journal 1990 (PubMed)
    Show all 4 references for 2180680

  3. Human CPE Protein expressed in HEK-293 Cells - ABIN2180678 : Jeffrey, Alejandro, Luciani, Kalynyak, Hu, Li, Lin, Townsend, Polonsky, Johnson: Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 4 references for 2180678

  4. Human CPE Protein expressed in Escherichia coli (E. coli) - ABIN1098768 : Chu, Briggs, Albrecht, Drain, Johnson: Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells. in Islets 2011 (PubMed)
    Show all 2 references for 1098768

  5. Human CPE Protein expressed in Human Cells - ABIN2215367 : Skalka, Caspi, Caspi, Loh, Rosin-Arbesfeld: Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. in Oncogene 2013 (PubMed)

更多Carboxypeptidase E互动伙伴

Human Carboxypeptidase E (CPE) interaction partners

  1. CPE through its N'-terminal sequence, forms aggregates with Wnt3a (显示 WNT3A 蛋白) and possible endoplasmic reticulum (ER) stress leading to its loss of function.

  2. we have identified a novel SNP in the CPE gene which results in the loss of its neuroprotective function in cells and may confer neurological disorders in humans

  3. High-level CPE [ carboxypeptidase E] expression was associated with a poor prognosis in early-stage cervical cancer. CPE may serve as a biomarker for predicting PLNM [ pelvic lymph node metastasis ] and survival in these patients.

  4. Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.

  5. Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin (显示 CCK 蛋白) and contribute to the formation of cholesterol gallstone.

  6. Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.

  7. Disruption of insulin receptor (IR (显示 INSR 蛋白)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (显示 EIF2A 蛋白) Eif4g1 (显示 EIF4G1 蛋白).

  8. Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.

  9. Data suggest that splice variant of carboxypeptidase E (CPE-DeltaN) that CPE-DeltaN expression might be a potential prognostic marker for colorectal cancer patients.

  10. CPE is essential in the process and targeting of neuropeptides and neurotrophins, its participation in the pathological progression of Alzheimer's disease may be suggested

Mouse (Murine) Carboxypeptidase E (CPE) interaction partners

  1. we show by RNA silencing that CPE and SgIII (显示 SCG3 蛋白) play a synergistic role in the trafficking of POMC (显示 POMC 蛋白) to granules of the regulated secretory pathway in AtT20 cells

  2. An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.

  3. This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 (显示 FGF2 蛋白) and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior

  4. The neuroprotective effect of CPE-DeltaN against neuronal glutamate (显示 GRIN1 蛋白) neurotoxicity was mediated by secreted FGF2 (显示 FGF2 蛋白).

  5. Carboxypeptidase E is an important modulator of RANKL (显示 TNFSF11 蛋白)-induced osteoclast differentiation.

  6. Report the effects of ovalbumin (显示 OVA 蛋白) sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.

  7. Disruption of insulin receptor (IR (显示 INSR 蛋白)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (显示 EIF2A 蛋白) Eif4g1 (显示 EIF4G1 蛋白).

  8. This study has identified CPE as a new neurotrophic factor (显示 NTF3 蛋白) that can protect neurons against degeneration.

  9. Data suggests that CPE plays critical role in neuroprotection/allostasis in hippocampal neurons during mild chronic stress; up-regulation of CPE and BCL2 (B cell leukemia/lymphoma 2) expression is possibly mediated by glucocorticoids.

  10. There are multiple mechanisms for sorting proglucagon (显示 GCG 蛋白) to the regulated secretory pathway, including a role for carboxypeptidase E in pancreatic alpha cells, initial cleavage at K70R71 and multiple sorting signals.

蛋白简介Carboxypeptidase E (CPE)


This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.

Alternative names and synonyms associated with Carboxypeptidase E (CPE)

  • carboxypeptidase E (CPE)
  • carboxypeptidase E (cpe)
  • carboxypeptidase E (Cpe)
  • CARBE 蛋白
  • CPE 蛋白
  • Cph 蛋白
  • Cph-1 蛋白
  • Cph1 蛋白
  • fat 蛋白
  • R74677 蛋白
  • si:ch211-198g9.2 蛋白
  • zgc:85981 蛋白

Protein level used designations for Carboxypeptidase E 蛋白 (CPE)

carboxypeptidase E , carboxypeptidase E preproprotein , carboxypeptidase E-like , CPH , carboxypeptidase H , cobalt-stimulated chromaffin granule carboxypeptidase , enkephalin convertase , insulin granule-associated carboxypeptidase , prohormone-processing carboxypeptidase

443028 Ovis aries
475492 Canis lupus familiaris
708881 Macaca mulatta
100127580 Xenopus (Silurana) tropicalis
100397838 Callithrix jacchus
100458397 Pongo abelii
1363 Homo sapiens
280753 Bos taurus
12876 Mus musculus
25669 Rattus norvegicus
407979 Danio rerio
100158368 Xenopus laevis
422424 Gallus gallus
100037304 Sus scrofa
461592 Pan troglodytes
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