anti-p53 (TP53) 抗体产品概述

Full name:
anti-Tumor Protein P53 抗体 (TP53)
在www.antibodies-online.cn可供2452 Tumor Protein P53 (TP53) 抗体的51不同的供货商。 再加上,我们可以发p53 试剂盒 (143)p53 蛋白 (84)和数多这个蛋白质的别的产品。 总共2844 p53产品已列进来了。
别名:
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919
列出全部抗体 基因 基因ID UniProt
TP53 22059 P02340
TP53 84260 Q9BT92
大鼠 TP53 TP53 24842 P10361

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引用最多的anti-p53 抗体

  1. Human Monoclonal p53 Primary Antibody for IHC (f), IHC (fro) - ABIN967416 : Cheng, Yee, Yeargin, Friedmann, Haas: Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. in Cancer research 1992 (PubMed)
    Show all 11 references for 967416

  2. Human Polyclonal p53 Primary Antibody for IF, IHC (p) - ABIN390204 : Blanchette, Cheng, Yan, Ketner, Ornelles, Dobner, Conaway, Conaway, Branton: Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for 390204

  3. Human Monoclonal p53 Primary Antibody for IHC (fro), IF - ABIN1108553 : Isobe, Emanuel, Givol, Oren, Croce: Localization of gene for human p53 tumour antigen to band 17p13. in Nature 1986 (PubMed)
    Show all 2 references for 1108553

  4. Horse (Equine) Polyclonal p53 Primary Antibody for IHC, WB - ABIN2792141 : Zakut-Houri, Bienz-Tadmor, Givol, Oren: Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. in The EMBO journal 1985 (PubMed)

  5. Cow (Bovine) Polyclonal p53 Primary Antibody for WB - ABIN2779979 : Rotter, Wolf, Pravtcheva, Ruddle: Chromosomal assignment of the murine gene encoding the transformation-related protein p53. in Molecular and cellular biology 1984 (PubMed)

  6. Human Polyclonal p53 Primary Antibody for ChIP, ELISA - ABIN2779319 : Boehme, Kulikov, Blattner: p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

更多抗p53的相互作用对抗体

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

  1. Key features of genome recognition by p53 and unprecedented insight into the pathways associated with p53 reactivation and tumour regression, paving the way for their therapeutic application.

  2. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 抗体)/NF-kappaB (显示 NFKB1 抗体)-regulated apoptosis and the p53/PCNA (显示 PCNA 抗体)- and ATM (显示 ATM 抗体)/ATR (显示 ATR 抗体)-Chk1 (显示 CHEK1 抗体)/2-controlled DNA-damage response pathways.

  3. The TP53 knockout shifted the phenotypes of A549 cells induced by ALKBH3 (显示 ALKBH3 抗体) knockdown from cell cycle arrest to apoptosis induction, suggesting that the TP53 gene status is a critical determinant of the phenotypes induced by ALKBH3 (显示 ALKBH3 抗体) knockdown in NSCLC cells.

  4. Our study demonstrates that unlike conventional tumoricidal therapies, which rely on effective p53 targeting in each tumor cell and often associate with systemic toxicity, this immune-based strategy requires only limited local p53 activation to alter the immune landscape of TME and subsequently amplify immune response to systemic antitumor immunity

  5. median survival of KPIC mice was longer than that of LSL-KrasG12D; Ink4flox/flox; Ptf1/p48 (显示 PTF1A 抗体)-Cre mice (KIC) (89 vs 62 days) and shorter than that of KRAS (KrasG12D), TP53 (Trp53R172H/+) and Ptf1/p48 (显示 PTF1A 抗体)-Cre (KPC) mice

  6. Combined deletion of Vhl (显示 VHL 抗体), Trp53 and Rb1 (显示 RB1 抗体) specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (显示 MOK 抗体).

  7. Data show that Emu-Myc (显示 MYC 抗体) mice lacking both p21 (显示 D4S234E 抗体) and PUMA (显示 BBC3 抗体) developed lymphoma at a rate considerably longer latency than Emu-Myc (显示 MYC 抗体);p53(+/-)mice.

  8. The loss of p53 function is a requirement for the formation of giant spermatogonia (GSG) whereas DNA damage acts as a promoting trigger. The formation of GSG does not translate to higher efficacy of testicular tumorigenesis arising from mutant p53 cells, which might be due to the presence of delayed-onset of p53-independent apoptosis.

  9. p21 (显示 D4S234E 抗体)-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 (显示 D4S234E 抗体) and ras(Ha)/ROCK2 (显示 ROCK2 抗体)/NF-kappaB (显示 NFKB1 抗体) signalling in skin carcinogenesis.these data show that ROCK2 (显示 ROCK2 抗体) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 loss and novel NF-kappaB (显示 NFKB1 抗体) expression

  10. TP53 mutation is associated with Triple-Negative Breast Cancer.

Human Tumor Protein P53 (TP53) interaction partners

  1. Data establish the DLX3 (显示 DLX3 抗体)-p53 interplay as a major regulatory axis in epidermal differentiation and suggest that DLX3 (显示 DLX3 抗体) is a modulator of skin carcinogenesis.

  2. Data show that Prima-1 kills hypoxic wt p53 KRAS-mutant cells resistant to 3-bromopyruvate (3-BrPA), partly by decreasing GLUT-1 (显示 SLC2A1 抗体) expression.

  3. Results indicate that the induction of long non-coding RNA NEAT1 expression contributes to the tumor-suppressor function of p53 and suggest that p53 and NEAT1 constitute a transcriptional network contributing to various biological functions and tumor suppression.

  4. HULC activates p53-p21 (显示 CDKN1A 抗体) pathway and promotes nasopharyngeal carcinoma cell growth.

  5. Mutations in TP53 and STK11 (显示 STK11 抗体) also impacted tumor biology regardless of KRAS status, with TP53 strongly associated with enhanced proliferation and STK11 (显示 STK11 抗体) with suppression of immune surveillance.

  6. Sp100A exhibits tumor-suppressive activity, not only by stabilizing p53 transactivation but also by depressing E1A (显示 BCKDHA 抗体)/E1B (显示 BCKDHB 抗体)-55K-mediated transformation.

  7. Here we present, as far as we are aware, the first case of metastatic microcystic adnexal carcinoma with DNA sequencing results indicating a mutation in TP53 and chromosomal losses in cyclin dependent kinase inhibitor 2A (CDKN2A (显示 CDKN2A 抗体)) and cyclin dependent kinase inhibitor 2B (CDKN2B (显示 CDKN2B 抗体)).

  8. This case contradicts previous reports of p53 and BRAF (显示 BRAF 抗体) mutations portending worsened tumor behavior and prognosis and demonstrates that further studies are needed to delineate the role of genetic characterization in the biologic understanding and management of gangliogliomas.

  9. This work highlights the importance of the p53-miR-191-SOX4 axis in the regulation of apoptosis and doxorubicin resistance in breast cancer cell lines (MCF7 and ZR-75)

  10. Results indicate that it is possible to detect mutated p53 genes with the circulating DNA (cirDNA) and that this could be used as a biomarker of tumor recurrence during the clinical evolution of the transplanted patients.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

  1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

  2. SIRT1 (显示 SIRT1 抗体), p53 and NF-kappaB (显示 NFKB1 抗体) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  4. Data indicate that higher hepatic glucocorticoid receptor (GR (显示 NR3C1 抗体)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (显示 SP1 抗体)).

  5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (显示 MAPK14 抗体) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  6. role of transcription factor p53 and the metabolic hormone leptin (显示 LEP 抗体), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (显示 BCL2 抗体) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  9. Suppressive effect of FSH (显示 BRD2 抗体) and LH on p53 expression and caspase-3 (显示 CASP3 抗体) activity with parallel increase in bcl-2 (显示 BCL2 抗体) expression and increased P production was observed.

  10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (显示 MAPK14 抗体) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (显示 MAPK14 抗体) plays a role by way of stimulating NF-kappaB (显示 NFKB1 抗体), p53 and caspase-3 (显示 CASP3 抗体) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (显示 BCL2 抗体) proteins.

  4. Chronically activated, monomeric PDGFRA (显示 PDGFRA 抗体) induced prolonged activation of Akt (显示 AKT1 抗体) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (显示 CASP3 抗体), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (显示 HDAC1 抗体) and DNMT3A (显示 DNMT3A 抗体) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (显示 AKT1 抗体) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

  1. Expression of p53 and Ki67 (显示 MKI67 抗体) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) interaction partners

  1. C/ebpalpha (显示 CEBPA 抗体) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (显示 KLF8 抗体), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (显示 MDM2 抗体) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) 抗原简介

Antigen Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758) 抗体
  • tumor protein p53 (TP53) 抗体
  • tumor supressor p53 (tp53) 抗体
  • p53 tumor suppressor (P53) 抗体
  • transformation related protein 53 (Trp53) 抗体
  • transformation related protein 53, pseudogene (Trp53-ps) 抗体
  • trichoplein, keratin filament binding (TCHP) 抗体
  • tumor protein p53 (Tp53) 抗体
  • tumor protein p53 (tp53) 抗体
  • Wistar clone pR53P1 p53 pseudogene (p53-ps) 抗体
  • bbl 抗体
  • BCC7 抗体
  • bfy 抗体
  • bhy 抗体
  • brp53 抗体
  • drp53 抗体
  • etID22686.5 抗体
  • fb40d06 抗体
  • LFS1 抗体
  • p44 抗体
  • P53 抗体
  • Tp53 抗体
  • TpMs 抗体
  • Trp53 抗体
  • wu:fb40d06 抗体
  • Xp53 抗体
  • zgc:111919 抗体

Protein level used designations for anti-Tumor Protein P53 (TP53) 抗体

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

GENE ID SPECIES
6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
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