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anti-p53 (TP53) 抗体产品概述

Full name:
anti-Tumor Protein P53 抗体 (TP53)
在www.antibodies-online.cn可供2312 Tumor Protein P53 (TP53) 抗体的50不同的供货商。 再加上,我们可以发p53 试剂盒 (122)p53 蛋白 (89)和数多这个蛋白质的别的产品。 总共2686 p53产品已列进来了。
别名:
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919

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引用最多的anti-p53 抗体

  1. Human Monoclonal p53 Primary Antibody for IHC (f), IHC (fro) - ABIN967416 : Cheng, Yee, Yeargin, Friedmann, Haas: Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. in Cancer research 1992 (PubMed)
    Show all 11 references for ABIN967416

  2. Human Polyclonal p53 Primary Antibody for IF, IHC (p) - ABIN390204 : Blanchette, Cheng, Yan, Ketner, Ornelles, Dobner, Conaway, Conaway, Branton: Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. in Molecular and cellular biology 2004 (PubMed)
    Show all 4 references for ABIN390204

  3. Human Monoclonal p53 Primary Antibody for IHC (fro), IF - ABIN1108553 : Isobe, Emanuel, Givol, Oren, Croce: Localization of gene for human p53 tumour antigen to band 17p13. in Nature 1986 (PubMed)
    Show all 2 references for ABIN1108553

  4. Human Polyclonal p53 Primary Antibody for ELISA, WB - ABIN1531937 : Kyriakis, Banerjee, Nikolakaki, Dai, Rubie, Ahmad, Avruch, Woodgett: The stress-activated protein kinase subfamily of c-Jun kinases. in Nature 1994 (PubMed)

  5. Human Polyclonal p53 Primary Antibody for IHC, ELISA - ABIN1531939 : Lohrum, Scheidtmann: Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes. in Oncogene 1997 (PubMed)

  6. Cow (Bovine) Polyclonal p53 Primary Antibody for WB - ABIN2779979 : Rotter, Wolf, Pravtcheva, Ruddle: Chromosomal assignment of the murine gene encoding the transformation-related protein p53. in Molecular and cellular biology 1984 (PubMed)

  7. Human Polyclonal p53 Primary Antibody for ChIP, IHC - ABIN2779318 : Boehme, Kulikov, Blattner: p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

更多抗p53的相互作用对抗体

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

  1. TWIST1 (显示 TWIST1 抗体)-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 (显示 TWIST1 抗体) with regard to senescence inhibition over the time course of breast tumorigenesis.

  2. We establishment the transgenic mouse model of K-ras (显示 HRAS 抗体)(G12D) p53(loxP/loxP) and found that K-ras (显示 HRAS 抗体) mutation and p53 deletion within the ovarian surface epithelium gave rise to ovarian lesions with a hyperproliferation and endometrioid glandular morphology

  3. this study shows that possible molecular mechanism involves the anti-inflammatory effects of parthenolide may be enhanced the p53 signals

  4. Activation of p53-mediated glucose metabolism led to an antidiabetic effect in this mouse model of type 2 diabetes.

  5. Data indicate that tumor supressor p53 enhances the engraftment of cardiac progenitor cells (CPCs) in the diabetic heart.

  6. present the first mouse model of mucinous tumor formation from ovarian cells and supporting evidence that mutant TP53 is a key regulator of EOC progression, differentiation, and responsiveness to steroid hormones

  7. Inhibition of MDM2 (显示 MDM2 抗体) re-sensitizes rapamycin resistant renal cancer cells via the activation of p53.

  8. Apple pectin could inhibit the progression of breast tumors by up-regulating the expression of TP53 and increasing the number of apoptotic cells.

  9. Study suggests that p53 is transcriptionally active in the brains of Down syndrome individuals and is associated with an increase in apoptotic markers in the presence of Alzheimer's disease pathology

  10. MYSM1 (显示 MYSM1 抗体) is a critical negative regulator of p53 transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA (显示 BBC3 抗体) expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cell function

Human Tumor Protein P53 (TP53) interaction partners

  1. results suggests that BRCA1 mutation carriers with breast cancer are more likely to have P53 overexpression compared with BRCA2 (显示 BRCA2 抗体) mutation carriers and non-carriers (Meta-analysis).

  2. Our study firstly identifies the role of SHARPIN (显示 SHARPIN 抗体) in promoting wild-type P53 degradation and correlates with poor prognosis in P53 wild-type breast cancer.

  3. This study has shown that by direct transcriptional activation of CerS6 (显示 CERS6 抗体), p53 can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response.

  4. Loss of heterozygosity of TP53, P16 (显示 CDKN2A 抗体), SMAD4 (显示 SMAD4 抗体) and APC (显示 APC 抗体) genes was observed in esophageal adenocarcinoma.

  5. mir (显示 MLXIP 抗体)-486-5p is positively regulated by mir (显示 MLXIP 抗体)-660-5p in lung cancer cell lines, through the mir (显示 MLXIP 抗体)-660-MDM2 (显示 MDM2 抗体)-p53 pathway.

  6. P53 role in neuroblastoma (显示 ARHGEF16 抗体) cell differentiation

  7. p53 overexpression may help judge the prognosis of patients who undergo pulmonary metastasectomy for metastatic colorectal cancer.

  8. We found the higher expression of P53 isoforms in inverted papilloma and squamous cell carcinomas compared to benign papillomas , suggesting their role in local aggressiveness and malignant proliferation in head-neck lesions.

  9. PCNA (显示 PCNA 抗体), bcl-2 (显示 BCL2 抗体) protein, and cyclin D1 (显示 CCND1 抗体) expressions could be useful in evaluating the proliferative activity of the tumor and the aggressiveness of the clinical presentation

  10. WDR79 (显示 WRAP53 抗体) colocalized and interacted with USP7 (显示 USP7 抗体) in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 (显示 MDM2 抗体) and p53, thereby increasing the stability and extending the half-life of the two proteins.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

  1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

  2. SIRT1 (显示 SIRT1 抗体), p53 and NF-kappaB (显示 NFKB1 抗体) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  4. Data indicate that higher hepatic glucocorticoid receptor (GR (显示 NR3C1 抗体)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (显示 SP1 抗体)).

  5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (显示 MAPK14 抗体) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  6. role of transcription factor p53 and the metabolic hormone leptin (显示 LEP 抗体), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (显示 BCL2 抗体) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  9. Suppressive effect of FSH (显示 BRD2 抗体) and LH on p53 expression and caspase-3 (显示 CASP3 抗体) activity with parallel increase in bcl-2 (显示 BCL2 抗体) expression and increased P production was observed.

  10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (显示 MAPK14 抗体) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (显示 MAPK14 抗体) plays a role by way of stimulating NF-kappaB (显示 NFKB1 抗体), p53 and caspase-3 (显示 CASP3 抗体) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (显示 BCL2 抗体) proteins.

  4. Chronically activated, monomeric PDGFRA (显示 PDGFRA 抗体) induced prolonged activation of Akt (显示 AKT1 抗体) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (显示 CASP3 抗体), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (显示 HDAC1 抗体) and DNMT3A (显示 DNMT3A 抗体) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (显示 AKT1 抗体) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

  1. Expression of p53 and Ki67 (显示 MKI67 抗体) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) interaction partners

  1. C/ebpalpha (显示 CEBPA 抗体) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (显示 KLF8 抗体), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (显示 MDM2 抗体) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) 抗原简介

Antigen Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758) 抗体
  • tumor protein p53 (TP53) 抗体
  • tumor supressor p53 (tp53) 抗体
  • p53 tumor suppressor (P53) 抗体
  • transformation related protein 53 (Trp53) 抗体
  • transformation related protein 53, pseudogene (Trp53-ps) 抗体
  • trichoplein, keratin filament binding (TCHP) 抗体
  • tumor protein p53 (Tp53) 抗体
  • tumor protein p53 (tp53) 抗体
  • Wistar clone pR53P1 p53 pseudogene (p53-ps) 抗体
  • bbl 抗体
  • BCC7 抗体
  • bfy 抗体
  • bhy 抗体
  • brp53 抗体
  • drp53 抗体
  • etID22686.5 抗体
  • fb40d06 抗体
  • LFS1 抗体
  • p44 抗体
  • P53 抗体
  • Tp53 抗体
  • TpMs 抗体
  • Trp53 抗体
  • wu:fb40d06 抗体
  • Xp53 抗体
  • zgc:111919 抗体

Protein level used designations for anti-Tumor Protein P53 (TP53) 抗体

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

GENE ID SPECIES
6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
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