ATM (ATM) ELISA试剂盒产品概述

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Ataxia Telangiectasia Mutated ELISA试剂盒 (ATM)
在www.antibodies-online.cn可供46 Ataxia Telangiectasia Mutated (ATM) ELISA试剂盒的10不同的供货商。 再加上,我们可以发ATM 抗体 (355)ATM 蛋白 (5)和数多这个蛋白质的别的产品。 总共420 ATM产品已列进来了。
别名:
AI256621, AT1, ATA, ATC, ATD, ATDC, ATE, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, TEL1, TELO1, Xatm

适于 ATM 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  2. TCTP (显示 TPT1 ELISA试剂盒) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

  3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

  4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

  5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

  6. ATM checkpoint kinase (显示 ATR ELISA试剂盒) plays a role in telomere maintenance that is independent of telomerase regulation.

  7. Drosophila ATM and Mre11 (显示 MRE11A ELISA试剂盒) are essential for the G2/M checkpoint induced by low-dose irradiation.

  8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Dna2 (显示 DNA2 ELISA试剂盒) co-localizes in foci with RPA (显示 RPA1 ELISA试剂盒) and is found in a complex with replication fork components And-1 and Mcm10 (显示 MCM10 ELISA试剂盒). Dna2 (显示 DNA2 ELISA试剂盒) interacts with the DSB repair and checkpoint proteins Nbs1 (显示 NLRP2 ELISA试剂盒) and ATM.

  2. ATM and ATR (显示 ATR ELISA试剂盒) prevent accumulation of chromosomal abnormalities by promoting Mre11 (显示 MRE11A ELISA试剂盒)/Rad50 (显示 RAD50 ELISA试剂盒)/Nbs1 (显示 NLRP2 ELISA试剂盒) dependent recovery of collapsed replication forks.

  3. ATM and ATR (显示 ATR ELISA试剂盒) phosphorylate the functionally critical replication protein Mcm2 (显示 MCM2 ELISA试剂盒) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (显示 TOPBP1 ELISA试剂盒) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (显示 TOPBP1 ELISA试剂盒) with ATR (显示 ATR ELISA试剂盒)(ATM and Rad3-related).

  6. ATM and ATR (显示 ATR ELISA试剂盒) control mitotic events in vertebrate cells by targeting CEP63 (显示 CEP63 ELISA试剂盒) and centrosome dependent spindle assembly.

  7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (显示 TOPBP1 ELISA试剂盒)-dependent activation of ATR (显示 ATR ELISA试剂盒)-ATRIP (显示 ATRIP ELISA试剂盒) in response to double-stranded DNA breaks.

  8. The Fanconi anemia protein FANCM (显示 FANCM ELISA试剂盒) is controlled by FANCD2 (显示 FANCD2 ELISA试剂盒) and the ATR (显示 ATR ELISA试剂盒)/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

  2. Characterization of ataxia (显示 USP14 ELISA试剂盒) telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. We report that endogenous huntingtin (显示 HTT ELISA试剂盒) protein directly participates in oxidative DNA damage repair. Using novel chromobodies to detect endogenous human huntingtin (显示 HTT ELISA试剂盒) in live cells, we show that localization of huntingtin (显示 HTT ELISA试剂盒) to DNA damage sites is dependent on the kinase activity of ataxia telangiectasia mutated (ATM) protein.

  2. The study showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

  3. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (显示 PALB2 ELISA试剂盒), CHEK2 (显示 CHEK2 ELISA试剂盒) and ATM

  4. Taken together, the findings suggest that a protein-protein interaction between ATM and p400 ATPase (显示 DNAH8 ELISA试剂盒) occurs independently of DNA damage and contributes to efficient DNA damage response and repair.

  5. following reprogramming the early and late replicating genome is differentially affected by copy number variations in ATM-deficient induced pluripotent stem cells (iPSCs) relative to wild-type iPSCs.

  6. ATM mutation is associated with ataxia (显示 USP14 ELISA试剂盒)-telangiectasia.

  7. Results provide evidence that ATM along with 53BP1 (显示 TP53BP1 ELISA试剂盒) is involved in breast cancer cells resistance for PARP (显示 COL11A2 ELISA试剂盒) inhibitor; its deficiency causes resistance in 53BP1 (显示 TP53BP1 ELISA试剂盒)-depleted tumor cells.

  8. WRNIP1 (显示 WRNIP1 ELISA试剂盒) connects PCNA (显示 PCNA ELISA试剂盒) monoubiquitination with ATMIN/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability.

  9. Mutant IDH1 (显示 IDH1 ELISA试剂盒) downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (显示 FUT1 ELISA试剂盒) self-renewal, independent of TET2 (显示 TET2 ELISA试剂盒).

  10. ATM rs189037 polymorphism is associated with reduced risk of T2DM

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. Ataxia (显示 USP14 ELISA试剂盒) telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

  2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

  3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. radiation-induced eNOS (显示 NOS3 ELISA试剂盒) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (显示 HSP90 ELISA试剂盒)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (显示 TRAF1 ELISA试剂盒)/NF-kappaB (显示 NFKB1 ELISA试剂盒)-regulated apoptosis and the p53 (显示 TP53 ELISA试剂盒)/PCNA (显示 PCNA ELISA试剂盒)- and ATM/ATR (显示 ATR ELISA试剂盒)-Chk1 (显示 CHEK1 ELISA试剂盒)/2-controlled DNA-damage response pathways.

  2. this study shows that Atm-/- mice are more susceptible to pulmonary Streptococcus pneumoniae infection in a manner consistent with inflammasome defects

  3. This study show that like ataxia (显示 USP14 ELISA试剂盒) telangiectasia cells, ISG15 (显示 ISG15 ELISA试剂盒) is elevated in Atm-deficient mouse cerebellums.

  4. This study identifies attenuation of type I interferon (显示 IFNA ELISA试剂盒) responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection.

  5. Mutant IDH1 (显示 IDH1 ELISA试剂盒) downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (显示 FUT1 ELISA试剂盒) self-renewal, independent of TET2 (显示 TET2 ELISA试剂盒).

  6. USP7 (显示 USP7 ELISA试剂盒) inhibition is selectively cytotoxic to CLL cells independently of ATM and p53 (显示 TP53 ELISA试剂盒) and synergizes with chemotherapy.

  7. Fractionated exposure to low doses of X-rays resulted in accumulation of DNA damage in the murine spleen and induction of apoptotic response in p53 (显示 TP53 ELISA试剂盒)/Atm-independent manner. Further studies are needed to understand the outcomes and molecular mechanisms underlying cellular responses and early induction of p38 (显示 CRK ELISA试剂盒) in response to prolonged exposure to IR.

  8. ATM, ATR (显示 ATR ELISA试剂盒) and DNA-PKcs (显示 PRKDC ELISA试剂盒) have unique and essential roles during the DNA damage response in the nervous system.

  9. TRAF6 (显示 TRAF6 ELISA试剂盒) and H2AX (显示 H2AFX ELISA试剂盒) overexpression and gammaH2AX (显示 H2AFX ELISA试剂盒)-mediated HIF1alpha (显示 HIF1A ELISA试剂盒) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (显示 HIF1A ELISA试剂盒)-driven tumorigenesis, glycolysis and metastasis.

  10. These results reveal a new requirement for ATMIN-dependent ATM signaling in TP53 (显示 TP53 ELISA试剂盒)-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors.

ATM 抗原简介

Antigen Summary

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names and synonyms associated with ATM

  • telomere fusion (tefu) Elisa Kit
  • ataxia telangiectasia mutated (atm) Elisa Kit
  • ataxia telangiectasia mutated (ATM) Elisa Kit
  • ataxia telangiectasia mutated (EDI_100660) Elisa Kit
  • ataxia telangiectasia mutated (CpipJ_CPIJ001772) Elisa Kit
  • ataxia telangiectasia mutated (BDBG_08252) Elisa Kit
  • ataxia telangiectasia mutated (PAAG_02532) Elisa Kit
  • ataxia telangiectasia mutated (MCYG_05088) Elisa Kit
  • ataxia telangiectasia mutated (VDBG_06833) Elisa Kit
  • ataxia telangiectasia mutated (atm) (ACLA_015700) Elisa Kit
  • ataxia telangiectasia mutated (atm) (AaeL_AAEL014900) Elisa Kit
  • ataxia telangiectasia mutated (MGYG_07634) Elisa Kit
  • ataxia telangiectasia mutated (PGTG_14279) Elisa Kit
  • ataxia telangiectasia mutated (Atm) Elisa Kit
  • ataxia telangiectasia mutated (LOC100349299) Elisa Kit
  • ataxia telangiectasia mutated homolog (human) (Atm) Elisa Kit
  • AI256621 Elisa Kit
  • AT1 Elisa Kit
  • ATA Elisa Kit
  • ATC Elisa Kit
  • ATD Elisa Kit
  • ATDC Elisa Kit
  • ATE Elisa Kit
  • atm Elisa Kit
  • atm/tefu Elisa Kit
  • C030026E19Rik Elisa Kit
  • CG6535 Elisa Kit
  • dATM Elisa Kit
  • Dmel\\CG6535 Elisa Kit
  • tef Elisa Kit
  • Tefu Elisa Kit
  • TEL1 Elisa Kit
  • TELO1 Elisa Kit
  • Xatm Elisa Kit

Protein level used designations for ATM

CG6535-PB , ataxia telangiectasia mutated , ataxia telengiesctasia mutated , ataxia-telangiectasia mutated , drosophila ATM , tefu-PB , chunp9624 , ataxia telangiectasia mutated (includes complementation groups A, C and D) , ataxia telangiectasia mutated protein , serine-protein kinase ATM-like , ataxia telangiectasia mutated (atm) , A-T mutated , AT mutated , TEL1, telomere maintenance 1, homolog , serine-protein kinase ATM , Ataxia telangiectasia gene mutated in human beings , ataxia telangiectasia mutated homolog , A-T mutated homolog , ATM (ataxia telangiectasia mutated) , ataxia telangiectasia gene mutated in human beings

GENE ID SPECIES
41839 Drosophila melanogaster
398148 Xenopus laevis
403064 Danio rerio
451530 Pan troglodytes
577188 Strongylocentrotus purpuratus
5882524 Entamoeba dispar SAW760
6032926 Culex quinquefasciatus
8501759 Ajellomyces dermatitidis SLH14081
9099145 Paracoccidioides sp. 'lutzii' Pb01
9230975 Arthroderma otae CBS 113480
9537397 Verticillium alfalfae VaMs.102
100026797 Monodelphis domestica
100061765 Equus caballus
100217707 Taeniopygia guttata
100427400 Macaca mulatta
100451505 Pongo abelii
100480638 Ailuropoda melanoleuca
4706457 Aspergillus clavatus NRRL 1
5565620 Aedes aegypti
10025630 Arthroderma gypseum CBS 118893
10535503 Puccinia graminis f. sp. tritici CRL 75-36-700-3
472 Homo sapiens
300711 Rattus norvegicus
100349299 Oryctolagus cuniculus
100717983 Cavia porcellus
100101922 Sus scrofa
479450 Canis lupus familiaris
526824 Bos taurus
395401 Gallus gallus
101105847 Ovis aries
11920 Mus musculus
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