anti-Nicastrin (NCSTN) 抗体产品概述

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anti-Nicastrin 抗体 (NCSTN)
在www.antibodies-online.cn可供125 Nicastrin (NCSTN) 抗体的22不同的供货商。 再加上,我们可以发Nicastrin 蛋白 (14)Nicastrin 试剂盒 (4)和数多这个蛋白质的别的产品。 总共153 Nicastrin产品已列进来了。
别名:
9430068N19Rik, AA727311, agro, Aph2, CG7012, D1Dau13e, DKFZp469O2418, Dmel\\CG7012, dNct, Kiaa0253, mKIAA0253, NCSTN, Nct, nic, S5A, ST96B

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  1. Chicken Monoclonal Nicastrin Primary Antibody for IF, WB - ABIN968805 : Chen, Yu, Arawaka, Nishimura, Kawarai, Yu, Tandon, Supala, Song, Rogaeva, Milman, Sato, Yu, Janus, Lee, Song, Zhang, Fraser, St George-Hyslop: Nicastrin binds to membrane-tethered Notch. in Nature cell biology 2001 (PubMed)
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更多抗Nicastrin的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Nicastrin (NCSTN) interaction partners

  1. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (显示 ABCA2 抗体)) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.

  2. Co-expression of Drosophila Pen-2 (显示 PSENEN 抗体) with Aph-1 (显示 APH1A 抗体) and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity

  3. Aph-1 (显示 APH1A 抗体) and Nct may form a subcomplex that stabilizes the Psn holoprotein at an early step in gamma-secretase assembly.

  4. the proper assembly of the Aph-1 (显示 APH1A 抗体).nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 (显示 APH1A 抗体) functions as a stabilizing scaffold in the assembly of this complex

  5. presenilin, nicastrin, APH-1 (显示 APH1A 抗体), and PEN-2 (显示 PSENEN 抗体), are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes

  6. Nicastrin is essential to early photoreceptor neuron development

Zebrafish Nicastrin (NCSTN) interaction partners

  1. Zebrafish have an orthologue of human NCSTN, transcripts of the zebrafish ncstn gene are provided maternally, and the gene is then transcribed throughout embryogenesis and in adult zebrafish. Zebrafish ncstn transcripts are present in ventricular cells of the developing brain, Ncstn protein likely plays a role in Notch (显示 NOTCH1 抗体) signaling within the proliferative ventricular zone.

Human Nicastrin (NCSTN) interaction partners

  1. The authors identified two nonsynonymous mutations in NCSTN in a white population, one of which had previously been described in African American and Chinese patients with HS. In addition, several intronic polymorphisms within the NCSTN were identified that were present at a significantly higher frequency in the HS population.

  2. The results lead the investigators to speculate that NCSTN may be one of the genes determining the clinical phenotype of follicular HS .

  3. Loss of function of nicastrin impacts on cell proliferation and differentiation-associated signalling pathways in a keratinocyte cell line.

  4. analysis of two novel mutations segregating with familial hidradenitis suppurativa (acne inversa) and acne conglobate in NCSTN

  5. Case Report: large Chinese family harboring novel NCSTN mutation associated with acne inversa.

  6. Nicastrin mutation is associated with schizophrenia.

  7. haploinsufficiency of the NCSTN gene caused by the nonsense mutation c.1258C>T (p.Q420X) contributes to the occurrence of hidradenitis suppurativa in this family.

  8. The "Lid" domain of nicastrin is not essential for regulating gamma-secretase activity.

  9. SNPs in Notch (显示 NOTCH1 抗体) pathway genes may be predictors of cutaneous melanoma disease-specific survival.

  10. Tumor necrosis factor-alpha (显示 TNF 抗体) and interleukin-10 (显示 IL10 抗体) levels were elevated in acne inversa patients with nicastrin or presenilin enhancer (显示 PSENEN 抗体) mutation.

Mouse (Murine) Nicastrin (NCSTN) interaction partners

  1. mice defective of the nicastrin subunit of gamma-secretase in oligodendrocytes have hypomyelination in the central nervous system.

  2. The results of this study showed that elevated p-tau levels in NCT cKO mice and have demonstrated that changes on p-tau were likely caused by enhanced activity of CDK5 (显示 CDK5 抗体) but not GSK3beta (显示 GSK3b 抗体).

  3. PS1 (显示 PSEN1 抗体)(exon8) interacts with nicastrin, participating in the gamma-secretase complex formation.

  4. nicastrin plays essential roles in the regulation of short- and long-term synaptic plasticity, highlighting the importance of gamma-secretase in the function of mature synapses

  5. These results reveal a key role for ncstn in modulating amyloid beta production and amyloid plaque formation.

  6. Upregulation of PS1 (显示 PSEN1 抗体)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.

  7. Pen-2 (显示 PSENEN 抗体), as well as nicastrin and Aph-1alpha (显示 APH1A 抗体), is dispensable for presenilin endoproteolysis

  8. SGK1 (显示 SGK1 抗体) is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.

  9. We propose a model that identifies critical TMDs of Aph-1 (显示 APH1A 抗体) for associations with Nct and PS for the stepwise assembly of gamma-secretase components.

  10. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (显示 ABCA2 抗体)) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.

Nicastrin (NCSTN) 抗原简介

Antigen Summary

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.

Alternative names and synonyms associated with Nicastrin (NCSTN)

  • nicastrin (NCSTN) 抗体
  • nicastrin (nct) 抗体
  • nicastrin (ncstn) 抗体
  • nicastrin (CpipJ_CPIJ001617) 抗体
  • nicastrin (Ncstn) 抗体
  • Protein APH-2 (aph-2) 抗体
  • 9430068N19Rik 抗体
  • AA727311 抗体
  • agro 抗体
  • Aph2 抗体
  • CG7012 抗体
  • D1Dau13e 抗体
  • DKFZp469O2418 抗体
  • Dmel\\CG7012 抗体
  • dNct 抗体
  • Kiaa0253 抗体
  • mKIAA0253 抗体
  • NCSTN 抗体
  • Nct 抗体
  • nic 抗体
  • S5A 抗体
  • ST96B 抗体

Protein level used designations for anti-Nicastrin (NCSTN) 抗体

CG7012-PA , CG7012-PC , CG7012-PD , CG7012-PE , agoraphobic , dNicastrin , nct-PA , nct-PC , nct-PD , nct-PE , nicastrin , ATAG1874 , anterior pharynx-defective 2 , membrane protein

GENE ID SPECIES
100058515 Equus caballus
42964 Drosophila melanogaster
457435 Pan troglodytes
488638 Canis lupus familiaris
494449 Danio rerio
719696 Macaca mulatta
6032584 Culex quinquefasciatus
100170459 Xenopus (Silurana) tropicalis
100172503 Pongo abelii
100549548 Meleagris gallopavo
100596812 Nomascus leucogenys
23385 Homo sapiens
59287 Mus musculus
289231 Rattus norvegicus
426905 Gallus gallus
100156098 Sus scrofa
514929 Bos taurus
172905 Caenorhabditis elegans
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