IL1A 蛋白 (IL1A)产品概述

Full name:
Interleukin 1 alpha 蛋白 (IL1A)
在www.antibodies-online.cn可供155 Interleukin 1 alpha (IL1A) 蛋白的22不同的供货商。 再加上,我们可以发IL1A 抗体 (449)IL1A 试剂盒 (201)和数多这个蛋白质的别的产品。 总共825 IL1A产品已列进来了。
Il-1, IL-1 alpha, IL-1A, IL-1alpha, IL1, IL1-ALPHA, IL1F1, L1A
列出全部蛋白 基因 基因ID UniProt
IL1A 111343  
IL1A 24493 P16598
IL1A 3552 P01583


按照种类IL1A 蛋白 (IL1A)


引用最多的IL1A 蛋白

  1. Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346 : Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996 (PubMed)
    Show all 6 references for 2007346

  2. Human IL1A Protein expressed in Human Cells - ABIN2002135 : Hogquist, Nett, Unanue, Chaplin: Interleukin 1 is processed and released during apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)
    Show all 5 references for 2002135

  3. Human IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667487 : Yatabe, Mochizuki, Takizawa, Chijiiwa, Okada, Kimura, Fujita, Matsumoto, Toyama, Okada: Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes. in Annals of the rheumatic diseases 2009 (PubMed)
    Show all 4 references for 2667487

  4. Human IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667482 : Boraschi, Tagliabue: The interleukin-1 receptor family. in Vitamins and hormones 2006 (PubMed)
    Show all 3 references for 2667482

  5. Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2667484 : Son, Roby: Interleukin-1alpha-induced chemokines in mouse granulosa cells: impact on keratinocyte chemoattractant chemokine, a CXC subfamily. in Molecular endocrinology (Baltimore, Md.) 2006 (PubMed)
    Show all 3 references for 2667484

  6. Human IL1A Protein expressed in HEK-293 Cells - ABIN2181296 : Bankers-Fulbright, Kalli, McKean: Interleukin-1 signal transduction. in Life sciences 1996 (PubMed)
    Show all 2 references for 2181296


Mouse (Murine) Interleukin 1 alpha (IL1A) interaction partners

  1. These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.

  2. Our findings indicate that IL-1 plays an important role in skin lesions of systemic lupus erythematosus (SLE), suggesting that IL-1 is a therapeutic target in skin lesions of SLE.

  3. our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE (显示 AGER 蛋白)-p38 MAPK (显示 MAPK14 蛋白) and calpain-1 (显示 CAPN1 蛋白) pathway in keratinocyte and this mechanism may play an important role during psoriasis.

  4. IL-1 and IL-36 have roles as inflammatory mediators in pustular psoriasis in a mouse model

  5. These data demonstrate that IL-1 functions as a mitogenic mediator of encephalitogenic Th17 cells rather than qualitative inducer of their generation

  6. Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.

  7. endothelial cells were identified as the primary cellular source of G-CSF (显示 CSF3 蛋白) during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.

  8. Studies indicate that SHP1 (显示 PTPN6 蛋白) and SYK (显示 SYK 蛋白) crosstalk as a critical regulator of MyD88 (显示 MYD88 蛋白) post-translational modifications and IL-1-driven inflammation.

  9. We investigated the role of IL-1 signaling during MAV (显示 KLHL2 蛋白)-1-induced encephalitis. Unexpectedly, the lack of IL-1 signaling increased the mortality and inflammation in mice infected with MAV (显示 KLHL2 蛋白)-1.

  10. As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP (显示 DDIT3 蛋白) intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells.

Human Interleukin 1 alpha (IL1A) interaction partners

  1. the results indicate prominent antagonistic effects of IL-1alpha on TGF-beta (显示 TGFB1 蛋白) regulated interferon (显示 IFNA 蛋白) signaling, as well as on a wide variety of other genes and pathways in fibroblasts.

  2. IL1A polymorphism rs1800587 is associated with chronic pain in patients with sickle cell disease.

  3. Data indicate that interleukin 1alpha (IL-1alpha) propiece can activate NF-kappa B (NFkappaB (显示 NFKB1 蛋白)) and Sp1 transcription factor (SP1 (显示 SP1 蛋白)).

  4. cytokines of the IL-1 family play an important role in homeostatic as well as "emergency" hematopoiesis and are involved in the pathogenesis of several myeloid and lymphoid hematological malignancies.

  5. These results suggest that IL-1alpha enhances the translocation of TRPA1 (显示 TRPA1 蛋白) to the plasma membrane via the activation of Erk (显示 EPHB2 蛋白) in A549.

  6. Single Nucleotide Variants of Candidate Genes in Aggrecan (显示 ACAN 蛋白) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  7. Polymorphisms of Il1a were not significantly associated with bipolar I disorder in Iranian patients.

  8. we show that IL-1 induces robust p38a (显示 MAPK14 蛋白) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (显示 MAPK14 蛋白) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 (显示 DUSP1 蛋白) through a negative feedback to pp38, its basal activity is controlled by both TAB1 (显示 TAB1 蛋白) and MKP1 (显示 DUSP1 蛋白) through a positive feedback loop.

  9. Studies indicate that interleukin (IL)-1beta (显示 IL1B 蛋白), IL-1alpha, IL-33 (显示 IL33 蛋白) and high-mobility group box 1 (HMGB1 (显示 HMGB1 蛋白)) enter the extracellular space through mechanisms collectively known as unconventional secretion.

  10. This study demonstrates that the rs3783553 polymorphism may be involved in susceptibility to endometrial cancer. The II genotype seems to be a protective factor for endometrial cancer in Chinese Han women.

Pig (Porcine) Interleukin 1 alpha (IL1A) interaction partners

Rabbit Interleukin 1 alpha (IL1A) interaction partners

Cow (Bovine) Interleukin 1 alpha (IL1A) interaction partners

  1. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.

  2. Testicular IL-1 alpha and IL-1 beta (显示 IL1B 蛋白) concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 (显示 IL6 蛋白) concentrations were greatest in the immediate pre-pubertal period.

  3. Genes for IL-1alpha and IL-1beta (显示 IL1B 蛋白) are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta (显示 IL1B 蛋白) may have different roles as regulating PGF (显示 PGF 蛋白)(2alpha) and PGE (显示 LIPF 蛋白)(2) production during luteal phase.

  4. non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties

  5. These results suggest that IL-1alpha and IL-1beta (显示 IL1B 蛋白) are produced by the stromal cells, that IL-1beta (显示 IL1B 蛋白) is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen (显示 PLG 蛋白) activator in bovine endometrial cells.



The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.

Alternative names and synonyms associated with IL1A

  • interleukin 1 complex (Il1)
  • interleukin 1 alpha (Il1a)
  • interleukin 1, alpha (IL1A)
  • interleukin 1, alpha (Il1a)
  • Il-1 蛋白
  • IL-1 alpha 蛋白
  • IL-1A 蛋白
  • IL-1alpha 蛋白
  • IL1 蛋白
  • IL1-ALPHA 蛋白
  • IL1F1 蛋白
  • L1A 蛋白

Protein level used designations for Interleukin 1 alpha 蛋白 (IL1A)

IL-1 alpha , interleukin-1 alpha , hematopoietin-1 , preinterleukin 1 alpha , pro-interleukin-1-alpha , interleukin 1-alpha , Interleukin-1 alpha , precursor interleukin-1alpha , interleukin 1 alpha , precursor interleukin 1 alpha

111343 Mus musculus
16175 Mus musculus
24493 Rattus norvegicus
3552 Homo sapiens
397094 Sus scrofa
403782 Canis lupus familiaris
100861289 Capra hircus
100009250 Oryctolagus cuniculus
281250 Bos taurus
493944 Felis catus
100135555 Cavia porcellus
100064969 Equus caballus
443404 Ovis aries
700193 Macaca mulatta
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