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Rat (Rattus) MAPK3 ELISA Kit for Sandwich ELISA - ABIN432074
Du, Wang, Wang: Role of RhoA/MERK1/ERK1/2/iNOS signaling in ocular ischemic syndrome. in Graefe's archive for clinical and experimental ophthalmology 2016
in diffuse malignant peritoneal mesothelioma (DMPM) persistent activation of ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and AKT (显示 AKT1 ELISA试剂盒) in miR (显示 MLXIP ELISA试剂盒)-34a-reconstituted cells was found to counteract the antiproliferative and proapoptotic effects of miRNA, yet not affecting its anti-invasive activity
These findings suggested that USP14 induces NF-kappaB (显示 NFKB1 ELISA试剂盒) activity and ERK1/2 (显示 MAPK1/3 ELISA试剂盒) phosphorylation triggered by microbial infection.
Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors.
The results of this study suggest for the first time that cadmium induces MUC8 expression via TLR4 (显示 TLR4 ELISA试剂盒)-mediated ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and p38 MAPK (显示 MAPK14 ELISA试剂盒) signaling pathway in human airway epithelial cells
Lysophosphatidylcholine induced nNOS (显示 NOS1 ELISA试剂盒) uncoupling and nNOS (显示 NOS1 ELISA试剂盒)(Ser852) phosphorylation, reduced NO and H2O2 production and improved superoxide production by modulating ERK1/2 (显示 MAPK1/3 ELISA试剂盒) activity in endothelial cells.
the D domain of LRRC4 (显示 LRRC4 ELISA试剂盒) anchors ERK1/2 (显示 MAPK1/3 ELISA试剂盒) in the cytoplasm and competitively inhibits MEK (显示 MAP2K1 ELISA试剂盒)/ERK (显示 EPHB2 ELISA试剂盒) activation in glioma cells.
GLUL (显示 GLUL ELISA试剂盒) knockdown markedly inhibited the p38 MAPK (显示 MAPK14 ELISA试剂盒) and ERK1/ERK2 (显示 MAPK1 ELISA试剂盒) signaling pathways in cultured breast cancer cells and reduces their proliferation.
These results suggested that HOXB7 (显示 HOXB7 ELISA试剂盒) stimulates ERK1/2 (显示 MAPK1/3 ELISA试剂盒) phosphorylation and provided evidence that HOXB7 (显示 HOXB7 ELISA试剂盒), besides its role in transcriptional regulation, also promotes cell motility and invasiveness.
High ERK1 expression is associated with castration-resistant prostate cancer.
combined use of butyrate and highly specific Syk (显示 SYK ELISA试剂盒) inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk (显示 SYK ELISA试剂盒)- and ERK1/2 (显示 MAPK1/3 ELISA试剂盒)-dependent manner.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 or Erk2 (显示 MAPK1 ELISA试剂盒) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (显示 CD44 ELISA试剂盒) expression, and increased CD44 (显示 CD44 ELISA试剂盒) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (显示 ICAM1 ELISA试剂盒) and VCAM-1 (显示 VCAM1 ELISA试剂盒) by activating the ERK1/2 (显示 MAPK1/3 ELISA试剂盒) pathway, resulting in the expression of ETB (显示 EDNRB ELISA试剂盒) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (显示 NFkBP65 ELISA试剂盒), ERK1, ERK2 (显示 MAPK1 ELISA试剂盒) and STAT1 (显示 STAT1 ELISA试剂盒) pathways.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL (显示 KITLG ELISA试剂盒) signaling.
At low oxLDL levels LOX-1 (显示 OLR1 ELISA试剂盒) activates the protective Oct-1 (显示 POU2F1 ELISA试剂盒)/SIRT1 (显示 SIRT1 ELISA试剂盒) pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 (显示 MAPK1/3 ELISA试剂盒) pathway.
Studies indicate that progesterone receptor (显示 PGR ELISA试剂盒) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (显示 CXCL9 ELISA试剂盒)-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and its target genes.
Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
ERK1 underexpression is associated with obesity.
ERK1/2 (显示 MAPK1/3 ELISA试剂盒)-Akt1 (显示 AKT1 ELISA试剂盒) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (显示 SH3GL1 ELISA试剂盒) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (显示 MAPK1 ELISA试剂盒) pathway
ERK1 and ERK2 (显示 MAPK1 ELISA试剂盒) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (显示 HSPA1A ELISA试剂盒) in response to heat stress is dependent on ERK (显示 MAPK1 ELISA试剂盒) activation in Pac2 (显示 PSMG2 ELISA试剂盒) cells.
Data define distinct roles for ERK1 and ERK2 (显示 MAPK1 ELISA试剂盒) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide (显示 NPPC ELISA试剂盒) and this process is related to the EGFR (显示 EGFR ELISA试剂盒) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 (显示 EGR1 ELISA试剂盒) via activation of ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and contributes to pulmonary vascular remodeling.
ER Ca(2 (显示 CA2 ELISA试剂盒)+) release enhances eNOS (显示 NOS3 ELISA试剂盒) Ser (显示 SIGLEC1 ELISA试剂盒)-635 phosphorylation and function via ERK1/2 (显示 MAPK1/3 ELISA试剂盒) activation.
Thrombospondin 1 (显示 THBS1 ELISA试剂盒), fibronectin (显示 FN1 ELISA试剂盒), and vitronectin (显示 VTN ELISA试剂盒) are differentially dependent upon RAS, ERK1/2 (显示 MAPK1/3 ELISA试剂盒), and p38 (显示 MAPK14 ELISA试剂盒) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 (显示 MAPK1/3 ELISA试剂盒) binding and their nuclear translocation play a crucial role in Egr-1 (显示 EGR1 ELISA试剂盒) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (显示 AKT1 ELISA试剂盒), mTOR (显示 FRAP1 ELISA试剂盒), p70S6K (显示 RPS6KB1 ELISA试剂盒), and ERK1/2 (显示 MAPK1/3 ELISA试剂盒).
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (显示 MAPK1 ELISA试剂盒).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 (显示 MAPK1/3 ELISA试剂盒) dependent.
Results suggest that estrogen receptors and the ERK1/2 (显示 MAPK1/3 ELISA试剂盒) signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (显示 BCL2L11 ELISA试剂盒).
Treatment with ERK (显示 MAPK1 ELISA试剂盒) inhibitors or ERK1/2 (显示 MAPK1/3 ELISA试剂盒) knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 (显示 MAPK1/3 ELISA试剂盒) signaling, has a substantial impact on T cell behavior.
CSF2 (显示 CSF2 ELISA试剂盒) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 (显示 MAPK1/3 ELISA试剂盒) MAPK (显示 MAPK1 ELISA试剂盒)-dependent MTOR (显示 FRAP1 ELISA试剂盒) signal transduction cascades.
PGRN (显示 GRN ELISA试剂盒) inhibits adipogenesis in porcine preadipocytes partially through ERK (显示 MAPK1 ELISA试剂盒) activation mediated PPARgamma (显示 PPARG ELISA试剂盒) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (显示 PRKAA1 ELISA试剂盒)/ERK (显示 MAPK1 ELISA试剂盒)/TSC2 (显示 TSC2 ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and JNK1 (显示 MAPK8 ELISA试剂盒)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 (显示 MAPK1/3 ELISA试剂盒) and p38 MAPK (显示 MAPK14 ELISA试剂盒) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (显示 IGF1 ELISA试剂盒) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (显示 IGF1R ELISA试剂盒)
The results suggest that the MPK-1 (显示 MAPK1 ELISA试剂盒)/ERK (显示 MAPK1 ELISA试剂盒) regulatory network, including FBF-1 (显示 FBF1 ELISA试剂盒), FBF-2, and LIP-1 (显示 CENPJ ELISA试剂盒), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (显示 FGFR3 ELISA试剂盒) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (显示 SUV420H1 ELISA试剂盒) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (显示 MAPK1 ELISA试剂盒) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (显示 CDC42 ELISA试剂盒) GTPase (显示 RACGAP1 ELISA试剂盒).
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (显示 MAPK6 ELISA试剂盒) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (显示 MAPK6 ELISA试剂盒) can both interact with SPOROCYTELESS/NOZZLE (SPL (显示 SGPL1 ELISA试剂盒)) in vitro and in vivo and can phosphorylate the SPL (显示 SGPL1 ELISA试剂盒) protein in vitro.
MKK4 (显示 MAP2K4 ELISA试剂盒), MKK5 (显示 MAP2K5 ELISA试剂盒), MKK7 (显示 MAP2K7 ELISA试剂盒), and MKK9, are responsible for the activation of MPK3 and MPK6 (显示 MAPK6 ELISA试剂盒) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 ELISA试剂盒) signaling through MKK4 (显示 MAP2K4 ELISA试剂盒)/5/7/9-MPK3/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (显示 MAPK6 ELISA试剂盒), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
Results demonstrated the contribution of MPK3 and MPK6 (显示 MAPK6 ELISA试剂盒) to riboflavin-induced resistance.
These results indicate that the MVB pathway is positively regulated by pathogen-responsive MPK3/6 through LIP5 phosphorylation and plays a critical role in plant immune system
MKK3-MPK6 is activated by blue light in a MYC2-dependent manner.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, mitogen-activated protein kinase 12
, stress-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase