anti-MAP2K2 (MAP2K2) 抗体产品概述

Full name:
anti-Mitogen-Activated Protein Kinase Kinase 2 抗体 (MAP2K2)
在www.antibodies-online.cn可供278 Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) 抗体的31不同的供货商。 再加上,我们可以发MAP2K2 蛋白 (21)MAP2K2 试剂盒 (10)和数多这个蛋白质的别的产品。 总共326 MAP2K2产品已列进来了。
别名:
AA589381, ATMKK2, CFC4, F27B13.50, F27B13_50, MAP KINASE KINASE 1, MAP kinase kinase 2, MAPKK2, MEK2, MK1, MK2, MKK2, PRKMK2

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引用最多的anti-MAP2K2 抗体

  1. Human Polyclonal MAP2K2 Primary Antibody for IF, WB - ABIN1882178 : Burroughs, Oh, Barrett, DiAugustine et al.: Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible ... in Molecular cancer research : MCR 2003 (PubMed)
    Show all 5 references for 1882178

  2. Human Polyclonal MAP2K2 Primary Antibody for IHC (p), WB - ABIN1881526 : Tran, Maurer, Nagamine: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. in Molecular and cellular biology 2003 (PubMed)
    Show all 5 references for 1881526

  3. Chicken Monoclonal MAP2K2 Primary Antibody for IHC (f), IF - ABIN967845 : Crews, Alessandrini, Erikson: The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 5 references for 967845

  4. Human Polyclonal MAP2K2 Primary Antibody for IHC (p), WB - ABIN197106 : Alessi, Saito, Campbell, Cohen, Sithanandam, Rapp, Ashworth, Marshall, Cowley: Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. in The EMBO journal 1994 (PubMed)
    Show all 2 references for 197106

  5. Human Polyclonal MAP2K2 Primary Antibody for IHC, ELISA - ABIN1531905 : Rosen, Ginty, Weber, Greenberg: Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. in Neuron 1994 (PubMed)
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  6. Cow (Bovine) Polyclonal MAP2K2 Primary Antibody for IHC, WB - ABIN2783572 : Adjei, Cohen, Franklin, Morris, Wilson, Molina, Hanson, Gore, Chow, Leong, Maloney, Gordon, Simmons, Marlow, Litwiler, Brown, Poch, Kane, Haney, Eckhardt: Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 (PubMed)

更多抗MAP2K2的相互作用对抗体

Human Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. High MEK2 expression is associated with inflammation.

  2. there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (显示 ICAM1 抗体)), ezrin (EZR (显示 EZR 抗体)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase (显示 NOS 抗体) 3 (NOS3 (显示 NANOS3 抗体)) gene expressions in metabolic syndrome patients.

  3. The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (显示 PTPN11 抗体)) syndrome

  4. Data show that mitogen-activated protein kinase (显示 MAPK1 抗体) kinases MEK1 (显示 MAP2K1 抗体)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

  5. the purpose of this paper was to investigate MAPK (显示 MAPK1 抗体) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

  6. at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (显示 MAP2K1 抗体)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (显示 MAP2K1 抗体)/2

  7. Endocytosis separates EGF (显示 EGF 抗体) receptors from endogenous fluorescently labeled HRas (显示 HRAS 抗体) and diminishes receptor signaling to MAP kinases in endosomes.

  8. MEK1 (显示 MAP2K1 抗体) levels are upregulated at transcriptional level whereas MEK2 levels are downregulated at posttranslational level.

  9. MEK1/2 inhibitor trametinib showed similar PFS and a response rate as docetaxel in patients with previously treated KRAS-mutant-positive non-small cell lung carcinoma.

  10. We report on a fourth familial case with transmission of CFC (显示 PTPN11 抗体) syndrome from father to son due to a novel heterozygous sequence change c.376A>G (p.N126D) in exon 3 of MEK2 gene.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. fluid shear stress induces autocrine TGF-beta (显示 TGFB1 抗体)/ALK5 (显示 TGFBR1 抗体)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (显示 MAP2K1 抗体)/2-mediated signaling.

  2. FGF2 (显示 FGF2 抗体) is an extracellular inducer of COUP-TFII (显示 NR2F2 抗体) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (显示 NR2F2 抗体) expression prior to the onset of osteogenic differentiation

  3. REDD1 (显示 DDIT4 抗体) is required for normal insulin (显示 INS 抗体)-stimulated signaling, and a subtle balance exists between MEK1 (显示 MAP2K1 抗体)/2, REDD1 (显示 DDIT4 抗体), and mTOR (显示 FRAP1 抗体)

  4. MEK1 (显示 MAP2K1 抗体) and MEK2 can substitute for each other but a minimum amount of MEK (显示 MDK 抗体) is critical for placenta development and embryo survival

  5. MK2 (显示 KCNA2 抗体)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.

  6. MK2 (显示 KCNA2 抗体) attenuates dendritic cell-mediated Th1 (显示 HAND1 抗体) differentiation and autoimmune encephalomyelitis.

  7. analysis of p38 (显示 CRK 抗体)-MK2 (显示 KCNA2 抗体)-activated Rsk (显示 RPS6KA1 抗体) signaling in toll (显示 TLR4 抗体)-like receptor-stimulated dendritic cells

  8. both MEK1 (显示 MAP2K1 抗体) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract

  9. MK2 (显示 KCNA2 抗体) is responsible for resistance of p53 (显示 TP53 抗体)-deficient tumors to cisplatin

  10. MK2 (显示 KCNA2 抗体) plays a critical role in the development of apoptosis.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. the AtMKK2-AtMPK10 (显示 MAPK10 抗体) MAPK (显示 MAPK1 抗体) module regulates leaf venation complexity by altering polar auxin transport efficiency

  2. Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (显示 MAPK4 抗体) activation concomitantly with MEKK1 (显示 MAP3K1 抗体) and MKK2 phosphorylation.

  3. Ca(2 (显示 CA2 抗体)+) signaling occurred upstream of the MEKK1 (显示 MAP3K1 抗体)-MKK2 pathway. MEKK1 (显示 MAP3K1 抗体) was phosphorylated by calcium/calmodulin (显示 CALM 抗体)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (显示 MAP3K1 抗体).

  4. Data indicate that MEKK2 (显示 MAP3K2 抗体) is required for the mekk1 (显示 MAP3K1 抗体), mkk1 (显示 MAP2K1 抗体) mkk2, and mpk4 (显示 MAPK4 抗体) autoimmune phenotypes.

  5. Data suggest that the MEKK1 (显示 MAP3K1 抗体)-MKK1 (显示 MAP2K1 抗体)/MKK2-MPK4 (显示 MAPK4 抗体) kinase cascade negatively regulates MEKK2 (显示 MAP3K2 抗体) and activation of MEKK2 (显示 MAP3K2 抗体) triggers SUMM2-mediated immune responses.

  6. Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.

  7. double loss-of-function mutant (mkk1 (显示 MAP2K1 抗体)/2) of MKK1 (显示 MAP2K1 抗体) and MKK2 is shown to have marked phenotypes in development and disease

  8. Activation of MPK4 (显示 MAPK4 抗体) by flg22 is impaired in the mkk1 (显示 MAP2K1 抗体) mkk2 double mutants, suggesting that MKK1 (显示 MAP2K1 抗体) and MKK2 function together with MPK4 (显示 MAPK4 抗体) and MEKK1 (显示 MAP3K1 抗体) in a MAP kinase (显示 MAPK1 抗体) cascade to negatively regulate innate immune responses in plants.

MAP2K2 抗原简介

Antigen Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Alternative names and synonyms associated with MAP2K2

  • mitogen activated protein kinase kinase 2 (Map2k2) 抗体
  • mitogen-activated protein kinase kinase 2 (MAP2K2) 抗体
  • mitogen-activated protein kinase kinase 2 (Map2k2) 抗体
  • mitogen-activated protein kinase kinase 2 (MKK2) 抗体
  • AA589381 抗体
  • ATMKK2 抗体
  • CFC4 抗体
  • F27B13.50 抗体
  • F27B13_50 抗体
  • MAP KINASE KINASE 1 抗体
  • MAP kinase kinase 2 抗体
  • MAPKK2 抗体
  • MEK2 抗体
  • MK1 抗体
  • MK2 抗体
  • MKK2 抗体
  • PRKMK2 抗体

Protein level used designations for MAP2K2

ERK activator kinase 2 , MAP kinase kinase 2 , MAPK/ERK kinase 2 , MAPKK 2 , MEK 2 , MEK2 , dual specificity mitogen-activated protein kinase kinase 2 , mitogen-activated protein kinase kinase 2, p45 , MAP kinase/Erk kinase , mitogen activated protein kinase kinase 2 , protein kinase, mitogen activated, kinase 2, p45 , dual specificity mitogen activated protein kinase kinase 2 , mitogen-activated protein kinase kinase type 2

GENE ID SPECIES
58960 Rattus norvegicus
5605 Homo sapiens
26396 Mus musculus
611939 Canis lupus familiaris
396349 Gallus gallus
510434 Bos taurus
829103 Arabidopsis thaliana
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